| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Research Abstract |
In this study, we have aimed to develop following two types of medical/dental devices that are effective for the implant treatment in next generation. One is the freestanding membrane of biological apatite (BAp) that can be applied to the guided bone regeneration (GBR) method with the suitable bioactivity for affected region. The other is the implant in that two functions of biostability and biocompatibility were harmonized by the bilayered structure of BAp/hydroxyapatite (HAp). Both devices were prepared by using a pulsed laser deposition (PLD) technique for a thin film and bilayer formation technology. The prepared thin films and the bilayer were evaluated on chemical, physical and molecular biology. Clinical simulation test of BApGBR membrane and the function harmonized implant was carried out by using the mandibular alveolar bone and the femoral defect model of dog. As the results, the usefulness of our devices was confirmed as an implant treatment in next generation.
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