Basic research for cancer therapy by knockdown of RNA binding protein
| Project/Area Number |
20390505
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
HIGASHINO Fumihiro Hokkaido University, 大学院・歯学研究科, 准教授 (50301891)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
TOTSUKA Yasunori 北海道大学, 大学院・歯学研究科, 教授 (00109456)
HIDA Kyouko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
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| Research Collaborator |
KAKUGUCHI Wataru 北海道大学, 大学院・歯学研究科, 日本学術振興会特別研究員
KUROSHIMA Takeshi 北海道大学, 大学院・歯学研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 口腔外科学一般 / HuR / ARE-mRNA / RNAi法 / ノックダウン / 口腔がん |
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| Research Abstract |
HuR is RNA binding protein which can protect ARE-mRNA from rapid degradation. In this study, we show that HuR-knockdown can change the malignant features of oral cancer cell. The findings show the potential of HuR-knockdown as an effective therapeutic approach.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium.2011
Author(s)
Kurosu T., Ohga N., Hida Y., Maishi N., Akiyama K., Kakuguchi W., Kuroshima T., Kondo M., Akino T., Totsuka Y., Shindoh M., Higashino F., Hida K.
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Journal Title
Br.J.Cancer 104
Pages: 819-829
Related Report
Peer Reviewed
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[Journal Article] Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.2008
Author(s)
Hata H., Kitamura T., Higashino F., Hida K., Yoshida K., Ohiro Y., Totsuka Y., Kitagawa Y., Shindoh M.
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Journal Title
Oncol Rep. 19
Pages: 1093-1098
Related Report
Peer Reviewed
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