| Project/Area Number |
20390508
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
HIKIJI Hisako 九州歯科大学, 歯学部, 教授 (50292876)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251)
NAKAMURA Motonao 東京大学, 大学院・医学系・研究科, 准教授 (40431762)
ISHII Satoshi 秋田大学, 医学部, 教授 (10300815)
TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
KOYAMA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (10241994)
TAKAHASH Yukiko 九州歯科大学, 歯学部, 助教 (10582778)
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| Research Collaborator |
SHIMIZU Takao 東京大学, 大学院・医学系・研究科, 教授
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
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| Keywords | 骨吸収性疾患 / 脂質リガンド / オーファン受容体 / GPCR受容体 |
|---|
| Research Abstract |
Lipids which mediate cell signals are called lipid mediators. Many lipid mediators exert their effects through G-protein coupled receptors(GPCR). We have investigated the GPCR-related lipid mediators which prevent bone destruction. We have reported that gene ablation of the receptor of leukotrienes(BLT1) inhibits the bone resorption. We have also clarified the bone-resorbing mechanisms in the other GPCRs.
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