Development of therapy targeting orphan GPCR-related lipid mediators for prevention of bone destruction

• Project/Area Number: 20390508
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: HIKIJI Hisako 九州歯科大学, 歯学部, 教授 (50292876)
• Co-Investigator(Kenkyū-buntansha): NISHIHARA Tatsuji 九州歯科大学, 歯学部, 教授 (80192251) ; NAKAMURA Motonao 東京大学, 大学院・医学系・研究科, 准教授 (40431762) ; ISHII Satoshi 秋田大学, 医学部, 教授 (10300815) ; TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454) ; KOYAMA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (10241994) ; TAKAHASH Yukiko 九州歯科大学, 歯学部, 助教 (10582778)
• Research Collaborator: SHIMIZU Takao 東京大学, 大学院・医学系・研究科, 教授
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 骨吸収性疾患 / 脂質リガンド / オーファン受容体 / GPCR受容体

Research Abstract

Lipids which mediate cell signals are called lipid mediators. Many lipid mediators exert their effects through G-protein coupled receptors(GPCR). We have investigated the GPCR-related lipid mediators which prevent bone destruction. We have reported that gene ablation of the receptor of leukotrienes(BLT1) inhibits the bone resorption. We have also clarified the bone-resorbing mechanisms in the other GPCRs.

Research Products

• [Journal Article] Reiter's syndrome(reactive arthritis) with trismus after intravesical BCG immunotherapy : A case report (2011)
  • Author(s): Hatano N, Hikiji H, Matsubara M, Saijo H, Chikazu D, Ohashi K, Mori Y, Susami T, Yoda T, Takato T
  • Journal Title: Asian. J. Oral. Maxillofac. Surg Volume: 23 Pages: 25-27
• [Journal Article] Perspectives on a new educational system for dental hygiene students in Japan (2011)
  • Author(s): Hikiji H, Kubota K, Takahashi Y, Kanehisa Y, Yoshino K, Sonoki K, Chiwata K, Inoue H, Tsujisawa T, Akiifusa S, Kakinoki Y, Nishihara T, Fukuta J
  • Journal Title: J. Dent. Edu Volume: 75 Pages: 563-571
• [Journal Article] 口腔保健学科1年生におけるproblem-based learning(PBL)テュートリアル教育の導入 (2011)
  • Author(s): 井上博雅, 園木一男, 吉野賢一, 辻澤利行, 金久弥生, 高橋由希子, 日高勝美, 千綿かおる, 引地尚子, 久保田浩三, 柿木保明
  • Journal Title: 九州歯会誌 Volume: 64(6) Pages: 230-239
  • NAID: 10027947637
• [Journal Article] Perspectives on a new educational system for dental hygiene students in Japan. (2011)
  • Author(s): Hikiji1 H, Kubota K, Takahashi Y, Kanehisa Y, Yoshino K, Sonoki K, Chiwata K, Inoue H, Tsujisawa T, Akiifusa S, Kakinoki Y, Nishihara T, Fukuta J.
  • Journal Title: J.Dent.Edu. 75 Pages: 563-571
• [Journal Article] Reiter's syndrome (reactive arthritis) with trismus after intravesical BCG immunotherapy : A case report. (2011)
  • Author(s): Hatano N, Hikijil H, Matsubara M, Saijo H, Chikazu D, Ohashi K, Mori Y, Susami T, Yoda T, Takato.
  • Journal Title: Asian.J.Oral.Maxillofac. Volume: 23 Pages: 25-27
  • Peer Reviewed
• [Journal Article] Evaluation and analysis of formation of bone at the palate in patients with cleft lip and palate after palatoplasty based on computed tomograms and three-dimensional data (2010)
  • Author(s): Saijo H, Mori Y, Fujihara H, Kanno Y, Chikazu D, Ohkubo K, Hikiji H, Iino M, Yonehara Y, Takato T
  • Journal Title: Scand J Plast Reconstr Surg Hand Surg Volume: 44(1) Issue: 1 Pages: 21-5
  • DOI: 10.3109/02844310903350857
• [Journal Article] Improvement in wound healing by a novel synthetic collage-gel dressing in genetically diabetic mice (2010)
  • Author(s): Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y, Seto I, Iino M, Takato T
  • Journal Title: Asian. J. Oral. Maxillofac. Surg Volume: 22 Pages: 61-67
• [Journal Article] 脂質メディエーターと骨代謝 (2010)
  • Author(s): 引地尚子
  • Journal Title: 九州歯会誌 Volume: 64(3) Pages: 59-65
  • NAID: 10026983221
• [Journal Article] Evaluation and analysis of formation of bone at the palate in patients with cleft lip and palate after palatoplasty based on computed tomograms and three-dimensional data. (2010)
  • Author(s): Saijo H, Mori Y, Fujihara H, Kanno Y, Chikazu D, Ohkubo K, Hikiji1 H, Iino M, Yonehara Y, Takato T.
  • Journal Title: Scand J Plast Reconstr Surg Hand Surg. 44(1) Pages: 21-25
• [Journal Article] Improvement in wound healing by a novel synthetic collage-gel dressing in genetically diabetic mice. (2010)
  • Author(s): Chikazu D, Taguchi T, Koyama H, Hikiji1 H, Fujihara H, Suenaga H, Saijo H, Mori Y, Seto I, Iino M, Takato T.
  • Journal Title: Asian. J.Oral.Maxillofac. Surg. 22 Pages: 61-67
• [Journal Article] 脂質メディエーターと骨代謝 (2010)
  • Author(s): 引地尚子
  • Journal Title: 九州歯会誌 64(3) Pages: 59-65
  • NAID: 10026983221
• [Journal Article] 脂質メディエーターと骨代謝 (2010)
  • Author(s): 引地尚子
  • Journal Title: 九州歯科学会雑誌 Volume: 64 Pages: 59-65
  • NAID: 10026983221
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss (2009)
  • Author(s): Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Issue: 50 Pages: 21294-21299
  • DOI: 10.1073/pnas.0905209106
  • Peer Reviewed
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. (2009)
  • Author(s): Hikiji1 H, Ishii S, Yokomizo T, Takato T, Shimizu T.
  • Journal Title: Proc Natl Acad Sci U S A. 106 Pages: 21294-21299
• [Journal Article] A distinctive role of the leukotriene B_4 receptor BLT1 in osteoclastic activity during bone loss (2009)
  • Author(s): Hisako Hikiji
  • Journal Title: Proceedings of the National Academy of Sciences 106 Pages: 21294-21299
  • Peer Reviewed
• [Journal Article] 下顎枝垂直骨切り術により顎関節症状が改善した2症例 (2008)
  • Author(s): 近津大地、森良之、引地尚子、西條英人、高戸毅
  • Journal Title: 日本形成外科学会会誌 Volume: 28 Pages: 461-465
• [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease (2008)
  • Author(s): Hikiji H, Takato T, Shimizu T, Ishii S
  • Journal Title: Progress Lipid Res Volume: 47 Issue: 2 Pages: 107-126
  • DOI: 10.1016/j.plipres.2007.12.003
• [Journal Article] A case of tumoural calcinosis in the temporomandibular joint associated with systemic sclerosis (2008)
  • Author(s): Chikazu D, Mori Y, Saijo H, Fujihara H, Ko E. C, Hikiji H, Yonehara Y, Takato T
  • Journal Title: Int. J. Oral Maxillofac. Surg Volume: 37(2) Pages: 190-193
• [Journal Article] Metastasis of prostate cancer to the mandibular condyle (2008)
  • Author(s): Saijo H, Chikazu D, Mori Y, Hikiji H, Yonehara Y, and Takato T
  • Journal Title: Asian. J. Oral. Maxillofac. Surg Volume: 20 Pages: 86-88
• [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. (2008)
  • Author(s): Hikiji1 H, Takato T, Shimizu T, Ishii S
  • Journal Title: Progress Lipid Res. 47 Pages: 107-126
• [Journal Article] A case of tumoural calcinosis in the temporomandibular joint associated with systemic sclerosis. (2008)
  • Author(s): Chikazu D, Mori Y, Saijo H, Fujihara H, Ko E.C, Hikiji1 H, Yonehara Y, Takato T.
  • Journal Title: Int.J.Oral Maxillofac. Surg. 37(2) Pages: 190-193
• [Journal Article] Metastasis of prostate cancer to the mandibular condyle. (2008)
  • Author(s): Saijo H, Chikazu D, Mori Y, Hikiji1 H, Yonehara Y, Takato T.
  • Journal Title: Asian.J.Oral.Maxillofac. Surg. 20 Pages: 86-88
• [Journal Article] The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease (2008)
  • Author(s): Hisako Hikiji
  • Journal Title: Prog Lipid Res 47 Pages: 107-26
  • Peer Reviewed
• [Journal Article] Reiter's syndrome (reactive arthritis) with trismus after intravesical BCG immunotherapy : A case report.
  • Author(s): Hatano N, Hikiji1 H, Matsubara M, Saijo H, Chikazu D, Ohashi K, Mori Y, Susami T, Yoda T, Takato T.
  • Journal Title: Asian.J.Oral.Maxillofac. Surg in press
• [Presentation] 右側上顎犬歯部歯肉に生じた腺腫様歯原性腫瘍の1例 (2010)
  • Author(s): 齋藤健太郎, 森良之, 引地尚子, 菅野勇樹, 杉山円, 前田祐二郎, 宇波雅人, 末永英之, 阿部雅修, 古賀陽子, 大久保和美, 西條英人, 近津大地, 高戸毅
  • Organizer: 第64回日本口腔科学会総会
  • Place of Presentation: 北海道
  • Year and Date: 2010-06-24
• [Presentation] Training in the New Dental Hygiene Education Curriculum in Japan (2010)
  • Organizer: 第58回国際歯科研究学会(JADR)総会・学術大会
  • Place of Presentation: 北九州
• [Presentation] The leukotriene B4 receptor BLT1 in osteoclasts plays an important role in bone loss (2010)
  • Author(s): Hikiji H, Ishii S, Yokomizo T, Shimizu T
  • Organizer: FASEB Summer Research Conferences.
  • Place of Presentation: Steamboat Springs, Colorado
• [Presentation] ロイコトリエンB4受容体BLT1の骨吸収機能の解析 (2010)
  • Author(s): 引地尚子
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京
• [Presentation] 口腔外科手術後の口腔ケアに対するリスクアセスメント (2010)
  • Author(s): 引地尚子, 高橋由希子, 山下善弘, 冨永和宏, 高橋哲, 福田仁一
  • Organizer: 第55回日本口腔外科学会総会
  • Place of Presentation: 千葉
• [Presentation] Oral Health Care Training in the New Dental Hygiene Education Curriculum in Japan. (2010)
  • Author(s): 引地尚子
  • Organizer: 第58回国際歯科研究学会(JADR)総会・学術大会
• [Presentation] The leukotriene B4 receptor BLT1 in osteoclasts plays an important role in bone loss. (2010)
  • Author(s): Hikiji H, Ishii S, Yokomizo T, Shimizu T
  • Organizer: FASEB Summer Research Conferences. Phospholipid Metabolism : Disease, Signal Transduction, and Membrane Dynamics.
  • Place of Presentation: Steamboat Springs, Colorado
• [Presentation] The leukotriene B4 receptor BLT1 in osteoclasts plays an important role in bone loss. (2010)
  • Author(s): Hikiji H, Ishii S, Yokomizo T, Shimizu T.
  • Organizer: FASEB Summer Research Conferences.Phospholipid Metabolism : Disease, Signal Transduction, and Membrane Dynamics.
  • Place of Presentation: Steamboat Springs, Colorado
• [Presentation] 片側顎裂に対する二次的骨移植-術後早期の評価と成長終了後の評価- (2009)
  • Author(s): 大久保和美, 須佐美隆史, 松崎雅子, 長濱浩平, 飯野光喜, 森良之, 近津大地, 西條英人, 大木明子, 引地尚子, 高戸毅
  • Organizer: 第33回口蓋裂学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] 東京大学医学部附属病院口腔外科顎関節外来を受診された患者についての臨床統計的考察 (2009)
  • Author(s): 松原稔, 引地尚子, 波田野典子, 西條英人, 近津大地, 森良之, 飯野光喜, 須佐美隆史, 依田哲也, 高戸毅
  • Organizer: 第22回日本顎関節学会総会
  • Place of Presentation: 東京
• [Presentation] 骨吸収におけるロイコトリエンB4受容体BLT1の機能解析 (2009)
  • Author(s): 引地尚子, 石井聡, 横溝岳彦, 清水孝雄
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 顔面多発骨折術後の二次変形に対して、頬骨形成術を施行した2例 (2008)
  • Author(s): 田口敬太, 西條英人, 森良之, 末永英之, 林伸子, 近津大地, 引地尚子, 飯野光喜, 高戸毅
  • Organizer: 第186回日本口腔外科学会関東地方会
  • Year and Date: 2008-11-22
• [Presentation] 新規コラーゲンゲルとbFGF併用による骨形成促進作用に関する検討 (2008)
  • Author(s): 引地尚子, 近津大地, 西條英人, 小笠原徹, 森良之, 飯野光喜, 須佐美隆史, 高戸毅
  • Organizer: 第53回口腔外科学会総会
  • Place of Presentation: 徳島
• [Presentation] 口唇口蓋裂症例における上顎骨骨延長の術後評価 (2008)
  • Author(s): 杉山円, 須佐美隆史, 森良之, 大久保和美, 近津大地, 西條英人, 高橋路子, 平野友紀子, 松崎雅子, 仲宗根愛子, 藤原久子, 大木明子, 引地尚子, 飯野光喜, 高戸毅
  • Organizer: 第32回日本口蓋裂学会総会・学術集会
  • Place of Presentation: 広島
• [Presentation] 両側下顎頭変形および開咬を呈した全身性エリテマトーデス(SLE)の1例 (2008)
  • Author(s): 波田野典子, 引地尚子, 仲宗根愛子, 荻原祐二, 依田哲也, 須佐美隆史, 高戸毅
  • Organizer: 第21回日本顎関節学会総会・学術大会
  • Place of Presentation: 大阪
• [Presentation] 新規合成コラーゲンゲルドレッシング材による創傷治癒効果に関する研究 (2008)
  • Author(s): 近津大地, 引地尚子, 藤原久子, 末永英之, 杉山円, 菅野勇樹, 西條英人, 小笠原徹, 森良之, 飯野光喜, 高戸毅
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: 徳島
• [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice (2008)
  • Author(s): Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y., Iino M., and Takato T
  • Organizer: 8th Asian Congress on Oral and Maxillofacial Surgery
• [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice (2008)
  • Author(s): Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y., Iino M., Takato T.
  • Organizer: 8th Asian Congress on Oral and Maxillofacial Surgery
• [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice : 8th ; November 3-7,2008 (2008)
  • Author(s): 引地尚子(Daichi Chikazu)
  • Organizer: 8^<th> Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Bangkok
• [Book] 第1章7節顎の外れを繰り返す患者が来院したら (2010)
  • Author(s): 引地尚子
  • Total Pages: 102
  • Publisher: 金原出版
• [Book] 医師\歯科医師のための口腔診療必携(第1章 7節)(顎の外れを繰り返す患者が来院したら?) (2010)
  • Author(s): 引地尚子
  • Total Pages: 102
  • Publisher: 金原出版
• [Book] 第1章 7節 顎の外れを繰り返す患者が来院したら?医師・歯科医師のための口腔診療必携.p102,2010. (2010)
  • Author(s): 引地尚子
  • Total Pages: 263
  • Publisher: 金原出版