Strategic research for the identification of novel osteogenic small compounds and their application to bone regeneration
| Project/Area Number |
20390509
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORI Yoshiyuki The University of Tokyo, 医学部附属病院, 准教授 (70251296)
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| Co-Investigator(Kenkyū-buntansha) |
CHIKAZU Daichi 東京医科大学, 医学部, 教授 (30343122)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
TEI Yuichi 東京大学, 大学院・工学系研究科, 教授 (30345053)
矢野 文子 東京大学, 大学院・医学系研究科, 特任助教 (80529040)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 骨再生療法 / 骨形成性低分子化合物 / 化合物スクリーニング / 化合物デリバリーシステム / (1)骨再生療法 |
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| Research Abstract |
This study aims to develop fundamental technologies for small compound-based bone regenerative medicine through the identification of novel osteogenic small compounds, the development of effective drug delivery system, and the assessment of bone regeneration activities of such compounds in bone defect models. Here we identified glabrisoflavone and icariin as osteogenic small compounds. In addition, we established calcium phosphate-based systems for the controlled release of those compounds, and verified their bone regeneration activities in animal models.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Development of high-throughput screening system for osteogenicdrugs using a cell-based sensor.2008
Author(s)
Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y,Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI
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Journal Title
Biochem Biophys Res Commun. 376(2)
Pages: 375-379
Related Report
Peer Reviewed
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[Presentation] A novel method for designing and fabricating custom-made artificial bones.2010
Author(s)
Kanno Y, Takato T, Saijo H, Igawa K, Seto I, Mori Y, Ohkubo K, Sasaki N, Suzuki S, Chung UI
Organizer
Bernd-Spiessl-Symposium 2010
Place of Presentation
Basel, Switzerland
Year and Date
2010-06-18
Related Report
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[Presentation] 進行性骨化性線維異形成症(FOP)患者に対する全身麻酔下での抜歯経験2009
Author(s)
森良之,須佐美隆史,西條英人,菅野勇樹,近津大地,末永英之,杉山円,前田祐二郎,斎藤健太郎,飯野光喜,高戸毅
Organizer
第54回日本口腔外科学会総会
Place of Presentation
札幌コンベンションセンター, 北海道
Related Report
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[Presentation] Cyclooxygenase-2は膜性骨の骨折治癒におけるkey factorである2009
Author(s)
近津大地,藤川由美子,末永英之,杉山円,古賀陽子,阿部雅修,西條英人,森良之,飯野光喜,高戸毅
Organizer
第54回日本口腔外科学会総会
Place of Presentation
札幌コンベンションセンター, 北海道
Related Report
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