| Project/Area Number |
20390509
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORI Yoshiyuki The University of Tokyo, 医学部附属病院, 准教授 (70251296)
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| Co-Investigator(Kenkyū-buntansha) |
CHIKAZU Daichi 東京医科大学, 医学部, 教授 (30343122)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
TEI Yuichi 東京大学, 大学院・工学系研究科, 教授 (30345053)
矢野 文子 東京大学, 大学院・医学系研究科, 特任助教 (80529040)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 骨再生療法 / 骨形成性低分子化合物 / 化合物スクリーニング / 化合物デリバリーシステム / (1)骨再生療法 |
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| Research Abstract |
This study aims to develop fundamental technologies for small compound-based bone regenerative medicine through the identification of novel osteogenic small compounds, the development of effective drug delivery system, and the assessment of bone regeneration activities of such compounds in bone defect models. Here we identified glabrisoflavone and icariin as osteogenic small compounds. In addition, we established calcium phosphate-based systems for the controlled release of those compounds, and verified their bone regeneration activities in animal models.
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