Involvement of sonic hedgehog signaling in secondary palate formation
| Project/Area Number |
20390510
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISEKI Sachiko Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80251544)
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| Co-Investigator(Kenkyū-buntansha) |
AMAGASA Teruo 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00014332)
SUDA Naoto 明海大学, 歯学部, 教授 (90302885)
SATO Yutaka 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90361716)
OTA Masato 東京医科歯科大学, 大学院・医歯学総川研究科, 助教 (70313228)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIROISHI Toshihiko 国立遺伝学研究所, 教授 (90171058)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 病態検査学 / ソニックヘッジホッグ / 口蓋 / エンハンサー / 口蓋裂 / Shh / 定量的ISH / MFCS4 / 組織特異的エンハンサー / 舌 |
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| Research Abstract |
MFCS4 is one of tissue specific enhancers of mouse sonic hedgehog (Shh) gene and responsible for inducing Shh expression in oropharyngeal epithelium. The expression is involved in arrangement of myotubes in the tongue, which allows the tongue to function in descending itself at the stage of secondary palatal elevation that requires space in the oral cavity.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Runx1 and Runx2 cooperate during sternal morphgenesis.2010
Author(s)
Kimura A., Inose H., Yano F., Fujita K., Ikeda T., Sato S., Iwasaki M., Jinno T., Ae K., Fukumoto S., Takeuchi Y., Itoh H., Imamura T., Kawaguchi H., Chung UI., Martin JF., Iseki S., Shinomiya K., Takeda S.
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Journal Title
Development. 137(7)
Pages: 1159-1167
Related Report
Peer Reviewed
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[Journal Article] FGF9 monomer/dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.2009
Author(s)
Harada M., Murakami H., Okawa A., Okimoto N., Hiraoka S., Nakahara T., Akasaka R., Shiraishi Y., Futatsugi N., Mizutani-Koseki Y., Kuroiwa A., Shirouzu M., Yokoyama S., Taiji M., Iseki S., Ornitz D.M. Koseki H.
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Journal Title
Nat.Genet. 41(3)
Pages: 289-298
Related Report
Peer Reviewed
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