• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Involvement of sonic hedgehog signaling in secondary palate formation

Research Project

Project/Area Number 20390510
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISEKI Sachiko  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80251544)

Co-Investigator(Kenkyū-buntansha) AMAGASA Teruo  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (00014332)
SUDA Naoto  明海大学, 歯学部, 教授 (90302885)
SATO Yutaka  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90361716)
OTA Masato  東京医科歯科大学, 大学院・医歯学総川研究科, 助教 (70313228)
Co-Investigator(Renkei-kenkyūsha) SHIROISHI Toshihiko  国立遺伝学研究所, 教授 (90171058)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords病態検査学 / ソニックヘッジホッグ / 口蓋 / エンハンサー / 口蓋裂 / Shh / 定量的ISH / MFCS4 / 組織特異的エンハンサー / 舌
Research Abstract

MFCS4 is one of tissue specific enhancers of mouse sonic hedgehog (Shh) gene and responsible for inducing Shh expression in oropharyngeal epithelium. The expression is involved in arrangement of myotubes in the tongue, which allows the tongue to function in descending itself at the stage of secondary palatal elevation that requires space in the oral cavity.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (22 results)

  • [Journal Article] Disintegration of the medial epithelial seam : Is cell death important in palatogenesis?2011

    • Author(s)
      Iseki S.
    • Journal Title

      Dev.Growth Diff. 53,(2)

      Pages: 125-276

    • NAID

      10027900580

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 唇顎口蓋裂患者の長期観察結果についての検討2010

    • Author(s)
      村嶋真由子、三島木節、阿部成宏、岡田尚子、香月佑子、飯島伸、佐藤豊、吉増秀實、壬生美智子、天笠光雄
    • Journal Title

      日本口蓋裂学会雑誌 32

      Pages: 173-185

    • NAID

      10029088900

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Runx1 and Runx2 cooperate during sternal morphgenesis.2010

    • Author(s)
      Kimura A., Inose H., Yano F., Fujita K., Ikeda T., Sato S., Iwasaki M., Jinno T., Ae K., Fukumoto S., Takeuchi Y., Itoh H., Imamura T., Kawaguchi H., Chung UI., Martin JF., Iseki S., Shinomiya K., Takeda S.
    • Journal Title

      Development. 137(7)

      Pages: 1159-1167

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disintegration of the medial epithelial seam : Is cell death important in palatogenesis2010

    • Author(s)
      Iseki S.
    • Journal Title

      Dev.Growth Differ.

      Volume: 53(2) Pages: 259-268

    • NAID

      10027900580

    • Related Report
      2010 Annual Research Report
  • [Journal Article] FGF9 monomer/dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.2009

    • Author(s)
      Harada M., Murakami H., Okawa A., Okimoto N., Hiraoka S., Nakahara T., Akasaka R., Shiraishi Y., Futatsugi N., Mizutani-Koseki Y., Kuroiwa A., Shirouzu M., Yokoyama S., Taiji M., Iseki S., Ornitz D.M. Koseki H.
    • Journal Title

      Nat.Genet. 41(3)

      Pages: 289-298

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cster of three long-range enhancers directs regional Shh expression in the epithelial linings.2009

    • Author(s)
      Sagai T., Amano T., Tamura M., Mizushina Y., Sumyama K., Shirishi T.
    • Journal Title

      Development. 136(10)

      Pages: 1665-1674

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel method of mouse ex utero transplantation ofhepatic progenitor cells into the fetal liver.2009

    • Author(s)
      Shikanai M., Asahina K., Iseki S., Teramoto K., Nishida T., Shimizu-Saito K., Ota M., Eto K., Teraoka H.
    • Journal Title

      Biochem.Res.Commun. 381(2)

      Pages: 276-282

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of Tenascin-W expression with mineralization in mouse calvarial development.2009

    • Author(s)
      Mikura A., Okuhara S., Saito M., Ota M.,Ueda K., Iseki S.
    • Journal Title

      Congenit.Anom.(Kyoto) 49(2)

      Pages: 77-84

    • NAID

      10027388147

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of Tenascin-W expression with mineralization in mouse calvarial development.2009

    • Author(s)
      三倉文子
    • Journal Title

      Ongenitaal Anomalies 49

      Pages: 77-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver.2009

    • Author(s)
      鹿内弥磨
    • Journal Title

      Biochem.Biophys.Res.Commun. 381

      Pages: 276-282

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Twist inducereversal of myotube formation.2008

    • Author(s)
      Hjiantoniou E., Anayasa M., Nicolaou P., Bantounas I., Saito M., Iseki S., Uney J.B., Phylactou L.A.
    • Journal Title

      Differentiation 76

      Pages: 182-192

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxcl mutant.2008

    • Author(s)
      Vivatbutsiri P., Ichinose S., Hytonen M., Sainio K., Eto K., Iseki S.
    • Journal Title

      J. Anat. 212

      Pages: 603-611

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell lineage in mammalian craniofacial mesenchyme.2008

    • Author(s)
      Yoshida T., Vivatbutsiri P., Morriss-Kay G., Saga Y., Iseki S.
    • Journal Title

      Mech.Dev. 125

      Pages: 797-808

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development and tissue origins of the mammalian cranial base.2008

    • Author(s)
      McBratney-Owen B., Iseki S., Bamforth S.D.Olsen B.R., Morriss-Kay G.M.
    • Journal Title

      Dev.Biol. 322

      Pages: 121-132

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell lineage in mammalian craniofacial mesenchyme2008

    • Author(s)
      葭田敏之
    • Journal Title

      Mechchanisms of Development 125

      Pages: 797-808

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and tissue origins of the mammalian cranial base2008

    • Author(s)
      Brandeis McBratney-Owen
    • Journal Title

      Developmental Biology 322

      Pages: 121-132

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胎児期低酸素状態が顔面形成に与える影響2010

    • Author(s)
      長岡亮介、奥原滋、天笠光雄、井関祥子
    • Organizer
      第50回日本先天異常学会学術集会
    • Place of Presentation
      淡路市
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Apert症候群型の変異FGFR2とその可溶性変異体を過剰発現するトランスジェニックマウスの解析2010

    • Author(s)
      鈴木尋之、須田直人、志賀百年、谷本幸穂、中村正孝、井関祥子、森山啓司
    • Organizer
      第69回日本矯正歯科学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] FGFシグナルの胎児マウス頭蓋冠骨芽細胞分化に与える影響2010

    • Author(s)
      永山友子、中原貴、太田正人、春日井昇平、井関祥子
    • Organizer
      第30回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of embryonic hypoxia maxillofacial development.2010

    • Author(s)
      Nagaoka R., Okuhara S., Amagasa T., Iseki S.
    • Organizer
      The 16th International Society of Differentiation Conference
    • Place of Presentation
      Nara
    • Related Report
      2010 Final Research Report
  • [Presentation] Cleft palate in compound heterozygote of sonic hedgehog and MFCS42010

    • Author(s)
      Okuhara S., Sagai T., Nagaoka R., Amano T., Shiroishi T., Iseki S.
    • Organizer
      The 16th International Society of Differentiation Conference
    • Place of Presentation
      Nara
    • Related Report
      2010 Final Research Report
  • [Presentation] Osteoblastic differentiation of transgenic mice overexpressing Apert syndrome-type mutant FGFR2 and its solubleform.2010

    • Author(s)
      鈴木尋之, 須田直人, 志賀百年., 谷本幸穂, 中村正孝, 井関祥子, 森山啓司
    • Organizer
      The 10th Tooth Morphogenesis and Differentiation
    • Place of Presentation
      Berlin
    • Related Report
      2010 Final Research Report
  • [Presentation] Cleft palate in mice of sonic hedgehog and its cis-regulatory region MF CS4 compound heterozygote2010

    • Author(s)
      Okuhara S, Sagai T, Nagaoka R Amano T, Shiroishi T, Iseki S
    • Organizer
      43^<rd> Annual Meeting for Japanese Society of Developmental Scientists
    • Place of Presentation
      京都市
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cleft palate in compound heterozygote of sonic hedgehog and MFCS42010

    • Author(s)
      Okuhara S, Sagai T, Nagaoka R Amano T, Shiroishi T, Iseki S
    • Organizer
      The 16th International Society of Differntiation Conference
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of embryonic hypoxia on maxillofacial development2010

    • Author(s)
      Nagaoka R, Okuhara S, Amagasa T, Iseki S
    • Organizer
      The 16th International Society of Differntiation Conference
    • Place of Presentation
      Nara, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] FGFR2IIIc-S252W及びSoluble form of FGFR2IIIc-S252Wトランスジェニックマウスを用いた頭蓋骨骨芽細胞の分化制御の検討2009

    • Author(s)
      鈴木尋之、須田直人、井関祥子、森山啓司
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of cis-regulatory element of sonic hedgehog in palatal development.2009

    • Author(s)
      Okuhara S., Sagai T., Shiroishi T., Iseki S.
    • Organizer
      16th International Society of Developmental Biologists Congress
    • Place of Presentation
      Edinburgh, England
    • Related Report
      2010 Final Research Report
  • [Presentation] FGF18-induced osteoblast differentiation in developing mouse fetal calvaria.2009

    • Author(s)
      井関祥子, 中原貴, 太田正人
    • Organizer
      The 26th NAITO Conference on Osteobiology
    • Place of Presentation
      Awaji Hyogo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of Foxcl in blood vessel formation of craniofacial region.2009

    • Author(s)
      Iseki S., Vivatbutsiri P., Okuhara S.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 片側性唇顎口蓋裂患者における口蓋形成術後の口蓋骨形成と上顎歯槽弓形態の検討2009

    • Author(s)
      五十嵐英、三島木節、香月佑子、長岡亮介、村嶋真由子、佐藤豊、吉増秀實、天笠光雄
    • Organizer
      第33回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] FGF18 enhances osteogenesis of mouse fetal skull bone.Gordon Research Conference2009

    • Author(s)
      永山友子, 中原貴, 太田正人, 井関祥子
    • Organizer
      Fibroblast Growth Factors in Development & Disease
    • Place of Presentation
      Ventura, California, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Twist reverses muscle cell differentiation.2009

    • Author(s)
      Nikolaos M., Mustafa A., Antonis, A., Iseki S., Uney J., Phylactou L.
    • Organizer
      Molecular and Cellular basis of Regeneration and Repair, EMBO Conference Series
    • Place of Presentation
      Sesimbra, Portugal
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of cis-regulatory element of sonic hedgehog in palatal development2009

    • Author(s)
      奥原滋
    • Organizer
      16th International Society of Developmental Biologists Congress
    • Place of Presentation
      英国エディンバラ
    • Related Report
      2009 Annual Research Report
  • [Presentation] Impaired meningeal development is associated with defects in skull bone development.2008

    • Author(s)
      Iseki S., Ichinose S., Vivatbutsiri P.
    • Organizer
      第48回日本先天異常学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] tenascin-Nの骨芽細胞分化への関与2008

    • Author(s)
      奥原滋、斎藤正寛、太田正人、井関祥子
    • Organizer
      第50回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Saethre-Chotzen症候群モデルマウスにおける頭蓋骨の成長2008

    • Author(s)
      塗隆志、上田晃一、井関祥子、太田正人、大場創介、奥原滋、三倉文子
    • Organizer
      第17回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Impaired meningeal development is associated with defects in skull bone development in the Foxc1 mutant mouse.2008

    • Author(s)
      Iseki S., Ichinose S., Vivatbutsiri P.
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Application of maxillary distraction for patients with cleft maxillary hypoplasia.2008

    • Author(s)
      Sato Y., Yoshimasu H., Amagasa T.
    • Organizer
      The 8th Asian Congress of Oral & Maxillofacial Surgery.
    • Place of Presentation
      Thailand
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi