PDE2 related signal・gene therapy on oral malignant tumor
| Project/Area Number |
20390513
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Mie University |
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Principal Investigator |
TAGAWA Toshiro Mie University, 大学院・医学系研究科, 教授 (30046346)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Taku 三重大学, 医学部附属病院, 講師 (80242965)
SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 悪性腫瘍 / phosphodiesterase / phosphodiesterase2 / 運動能 / 悪性黒色腫細胞 / phosphodiesterase 2 / phosphodicsterase / 悪性黒色腫 |
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| Research Abstract |
Until now we had studied PDE2 of human oral malignant melanoma PMP cells. In this study, we examined PDE2 functions, and PDE2 expressions and characterizations of other malignant tumor cells. PDE2 expressed in a few malignant tumor cells. PDE2 did not relate apoptosis and migration. But, PDE2 related DNA synthesis and it was suggested that PDE2 regulated cell cycle.
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Report
(4 results)
Research Products
(8 results)
