PDE2 related signal・gene therapy on oral malignant tumor

• Project/Area Number: 20390513
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Mie University
• Principal Investigator: TAGAWA Toshiro Mie University, 大学院・医学系研究科, 教授 (30046346)
• Co-Investigator(Kenkyū-buntansha): MURATA Taku 三重大学, 医学部附属病院, 講師 (80242965) ; SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 悪性腫瘍 / phosphodiesterase / phosphodiesterase2 / 運動能 / 悪性黒色腫細胞 / phosphodiesterase 2 / phosphodicsterase / 悪性黒色腫

Research Abstract

Until now we had studied PDE2 of human oral malignant melanoma PMP cells. In this study, we examined PDE2 functions, and PDE2 expressions and characterizations of other malignant tumor cells. PDE2 expressed in a few malignant tumor cells. PDE2 did not relate apoptosis and migration. But, PDE2 related DNA synthesis and it was suggested that PDE2 regulated cell cycle.

Research Products

• [Presentation] 口腔由来悪性黒色腫PMP細胞でのPDE2特異的阻害剤の効果. (2011)
  • Author(s): 森田寛, 村田琢, 清水香澄, 渡邉由裕, 田川俊郎
  • Organizer: 第29回日本口腔腫瘍学会総会.
  • Place of Presentation: 熊本.
  • Year and Date: 2011-01-28
• [Presentation] 口腔由来悪性黒色腫PMP細胞でのPDE2特異的阻害剤の効果 (2011)
  • Author(s): 森田寛
  • Organizer: 第29回日本口腔腫瘍学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 2011-01-28
• [Presentation] ヒト口蓋由来悪性黒色腫細胞でのcGMP-stimulated phosphodiesteraseの発現とシークエンス. (2009)
  • Author(s): 森田寛, 清水香澄, 村田琢, 田川俊郎.
  • Organizer: 第37回三重歯科・口腔外科学会
  • Place of Presentation: 三重.
  • Year and Date: 2009-12-13
• [Presentation] ヒト口蓋由来悪性黒色腫細胞でのcGMP-stimulated phosphodiesteraseの発現とシークエンス (2009)
  • Author(s): 森田寛, 清水香澄, 村田琢, 田川俊郎
  • Organizer: 第37回三重歯科・口腔外科学会
  • Place of Presentation: 三重
  • Year and Date: 2009-12-13
• [Presentation] ヒト口蓋由来悪性黒色腫PMP細胞でのphosphodiesterase 2スプライシングバリアントの発現. (2009)
  • Author(s): 森田寛, 清水香澄, 竹岡高志, 柳瀬成章, 中村真之介, 乾眞登可, 田川俊郎
  • Place of Presentation: 東京.
  • Year and Date: 2009-12-05
• [Presentation] ヒト口蓋由来悪性黒色腫PMP細胞でのphosphodiesterase 2スプライシングバリアントの発現 (2009)
  • Author(s): 森田寛, 清水香澄, 竹岡高志, 柳瀬成章, 中村真之介, 乾眞登可, 田川俊郎
  • Organizer: 第46回日本口腔組織培養学会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-05
• [Presentation] Toshiro Tagawa Relationship between Phosphodiesterase2 and Growth in Oral Malignant Melanoma cells. (2008)
  • Author(s): Kasumi Shimizu, Kenichi Hiramoto, Taku Murata, Yoshihiro Watanabe, Madoka Inui
  • Organizer: 9th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Bangkok, Thailand.
  • Year and Date: 2008-11-06
• [Presentation] Relationship between Phosphodiesterase2 and Growth in Oral Maiignant Melanoma cells (2008)
  • Author(s): 清水香澄
  • Organizer: 第8回アジア顎顔面口腔外科学会
  • Place of Presentation: バンコク
  • Year and Date: 2008-11-06