Telomerase-Specific Replication-Selective Virotherapy for oral squamous cell carcinoma cell lines

• Project/Area Number: 20390520
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: SHINTANI Satoru Showa University, 歯学部, 教授 (80294429)
• Co-Investigator(Kenkyū-buntansha): HATORI Masashi 昭和大学, 歯学部, 准教授 (20245814) ; ITO DAISUKE 東京医科歯科大学, 硬組織疾患ゲノムセンター, 特任講師 (40286844)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 口腔癌 / テロメラーゼ / ウイルス治療 / 口腔扁平上皮癌 / テロメライシン / テロメスキャン / ウィルス性剤 / 癌の可視化

Research Abstract

Telomerase activation is considered to be a critical step in carcinogenesis, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells. We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on oral squamous cell carcinoma (OSCC) cells.

Research Products

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