| Project/Area Number |
20390523
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANNE Kazuo Hiroshima University, 医歯薬学総合研究科, 教授 (30159032)
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| Co-Investigator(Kenkyū-buntansha) |
TANIMOTO Kotaro 広島大学, 病院, 講師 (20322240)
NOBUAKI Tanaka 広島大学, 大学院・医歯薬学総合研究科, 助教 (90397969)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | Superficial zone protein / 下顎頭 / 軟骨 / 成長因子 / サイトカイン |
|---|
| Research Abstract |
The modulation process of superficial zone protein (SZP), a lubricant in temporomandibular joint, was clarified. The expression of SZP was higher in the superficial layer of condylar cartilage than that in other layers. In addition, the expression of SZP was down-regulated by a proinflammatory cytokine, IL-1β, leading to a deterioration of lubrication and degenerative changes in TMJ under inflammatory conditions. Hyaluronan (HA) is a major lubricant in synovila fluid, and low moleculer weight HA was accumulated in TMJ under excessive loading. The synthesis of low moleculer weight HA in synovial membrane cells was up-regulated by IL-1β. At the same time, the degradation of HA by hyaluronidase expressed by synovial membrane cells was enhanced by IL-1β. These results suggested a possible mechanism of fragmentation of HA in TMJ under inflammatory conditions. In addition, it was suggested that low molecular weight HA affects the expression of SZP through cells surface receptor in synovial membrane cells.
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