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Periodontal system biology: analysis of molecular bases of periodontal disease associated genes.

Research Project

Project/Area Number 20390529
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

YAMADA Satoru  Osaka University, 歯学部・附属病院, 講師 (40359849)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Shinya  大阪大学, 大学院・歯学研究科, 教授 (70239490)
KITAMURA Masahiro  大阪大学, 大学院・歯学研究科, 准教授 (10243247)
YANAGITA Manabu  大阪大学, 大学院・歯学研究科, 助教 (80379081)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords歯周病学 / 歯根膜 / 歯根膜特異的Periostinアイソフォーム / グルタミン酸 / 歯周病関連遺伝子 / トランスジェニックマウス / PLAP-1 / 遺伝子型
Research Abstract

this study, we constructed the periodontal system biology network database (PsBND) and analyzed the PsBND database comparing with other gene expression databases in order to identify periodontal ligament-specific genes. We found novel Periostin isoforms, glutamate-signaling associated molecules induced by mechanical stress and PLAP-1 periodontal ligament-specific. Functional analysis revealed that these molecules harmonized to keep homeostasis of periodontal ligament tissues.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (18 results)

  • [Journal Article] Role of Mechanical stress-induced glutamate signaling-associated molecules in cytodifferentiation of periodontal ligament cells.2010

    • Author(s)
      Fujihara C, Yamada S, Ozaki N, Takeshita N, Kawaki H, Takano-Yamamoto T, Murakami S
    • Journal Title

      J Biol Chem 285

      Pages: 28286-28297

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Mechanical stress-induced glutamate signaling-associated molecules in cytodifferentiation of periodontal ligament cells.2010

    • Author(s)
      Fujihara C, Yamada S, et al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 28286-28297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cathepsin K expression in human periodontal ligament cells2011

    • Author(s)
      Ozaki N, Yamada S, Fujihara C, Tauchi T, Kajikawa T, Awata T, Ozawa Y Murakami S
    • Organizer
      89^<th> IADR
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Mechanical stress induced glutamate signaling associated molecules regulate the cytodifferentiation of periodontal ligament cells2010

    • Author(s)
      山田聡
    • Organizer
      韓国歯周病学会50周年記念大会
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト歯根膜組織完全長cDNAライブラリーを用いたCathepsin Kの同定および機能解析2010

    • Author(s)
      尾崎亘弘、山田聡、藤原千春、田内拓史、梶川哲宏、粟田敏仁、小澤康宏、村上伸也
    • Organizer
      第133回日本歯科保存学会秋季学術大会
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト歯根膜組織完全長cDNAライブラリーを用いたCathepsin Kの同定および機能解析2010

    • Author(s)
      尾崎亘弘
    • Organizer
      第133回日本歯科保存学会秋季学術大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gene polymorphism in PLAP-1/asporin regulates mineralization of periodontal ligament cells2010

    • Author(s)
      梶川哲宏, 山田聡, 小澤康宏, 藤原千春, 田内拓史, 尾崎亘弘, 村上伸也
    • Organizer
      88^<th> IADR
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Gene polymorphism in PLAP-1/asporin regulates mineralization of periodontal ligament cells2010

    • Author(s)
      Tetsuhiro Kajikawa
    • Organizer
      88^<th> IADR
    • Place of Presentation
      バルセロナ、スペイン
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス歯周組織発生過程におけるPLAP-1タンパクの発現解析2010

    • Author(s)
      梶川哲宏、山田聡、小澤康宏、藤原千春、田内拓史、尾崎亘弘、村上伸也
    • Organizer
      第132回日本歯科保存学会春季学術大会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規歯根膜特異的PeriostinアイソフォームType IIの機能解析2010

    • Author(s)
      田内拓史、山田聡、前田憲一郎、藤原千春、梶川哲宏、尾崎亘弘、村上伸也
    • Organizer
      第53回春季日本歯周病学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Cathepsin K expression in human periodontal ligament cells2010

    • Author(s)
      Nobuhiro Ozaki
    • Organizer
      89^<th> IADR
    • Place of Presentation
      サンディエゴ、アメリカ
    • Year and Date
      2010-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] グルタミン酸シグナルによる歯根膜細胞の分化制御2009

    • Author(s)
      藤原千春、山田聡、田内拓史、梶川哲宏、尾崎亘弘、小澤康宏、村上伸也
    • Organizer
      第131回日本保存学会秋季大会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] グルタミン酸シグナルによる歯根膜細胞の分化制御2009

    • Author(s)
      藤原千春
    • Organizer
      第131回日本歯科保存学会秋季大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯周組織恒常性維持の分子基盤研究-歯根膜特異的分子PLAP-1の解析-2009

    • Author(s)
      山田聡
    • Organizer
      第59回春季日本歯周病学会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織恒常性維持の分子基盤研究-歯根膜特異的分子PLAP-1の解析-2009

    • Author(s)
      山田聡
    • Organizer
      第59回春季日本歯周病学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス歯周組織におけるPLAP-1タンパクの発現2009

    • Author(s)
      梶川哲宏、山田聡、小澤康宏、藤原千春、田内拓史、平野裕之、村上伸也
    • Organizer
      第59回春季日本歯周病学会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス歯周組織におけるPLAP-1タンパクの発現2009

    • Author(s)
      梶川哲弘
    • Organizer
      第59回春季日本歯周病学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Periodontal ligament-specific periostin positively regulates mineralization of periodontal ligament cells2009

    • Author(s)
      Yamada S, Tauchi T, Fujihara C, Kajikawa T, Ozawa Y, Kitamura M, Murakami S
    • Organizer
      87^<th> IADR
    • Place of Presentation
      Miami, USA
    • Year and Date
      2009-04-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal ligament-specific periostin positively regulates mineralization of periodontal ligament cells2009

    • Author(s)
      Satoru Yamada
    • Organizer
      International Association of Dental Research (IADR) 87th General session
    • Place of Presentation
      マイアミ、米国
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanical stress-induced glutamate signaling in periodontal ligament cells2008

    • Author(s)
      Fujihara C, Yamada S, Yoneda S, Tauchi T, Kajikawa T, Ozawa Y, Murakami S
    • Organizer
      86^<th> IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2008-07-05
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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