Periodontal system biology: analysis of molecular bases of periodontal disease associated genes.
| Project/Area Number |
20390529
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMADA Satoru Osaka University, 歯学部・附属病院, 講師 (40359849)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Shinya 大阪大学, 大学院・歯学研究科, 教授 (70239490)
KITAMURA Masahiro 大阪大学, 大学院・歯学研究科, 准教授 (10243247)
YANAGITA Manabu 大阪大学, 大学院・歯学研究科, 助教 (80379081)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 歯周病学 / 歯根膜 / 歯根膜特異的Periostinアイソフォーム / グルタミン酸 / 歯周病関連遺伝子 / トランスジェニックマウス / PLAP-1 / 遺伝子型 |
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| Research Abstract |
this study, we constructed the periodontal system biology network database (PsBND) and analyzed the PsBND database comparing with other gene expression databases in order to identify periodontal ligament-specific genes. We found novel Periostin isoforms, glutamate-signaling associated molecules induced by mechanical stress and PLAP-1 periodontal ligament-specific. Functional analysis revealed that these molecules harmonized to keep homeostasis of periodontal ligament tissues.
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Report
(4 results)
Research Products
(20 results)
