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Molecular basis of predictable periodontal regeneration

Research Project

Project/Area Number 20390530
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

MURAKAMI Shinya  Osaka University, 大学院・歯学研究科, 教授 (70239490)

Co-Investigator(Kenkyū-buntansha) YAMADA Satoru  大阪大学, 歯学部附属病院, 講師 (40359849)
HASHIKAWA Tomoko  大阪大学, 大学院・歯学研究科, 助教 (00362682)
YANAGITA Minabu  大阪大学, 大学院・歯学研究科, 助教 (80379081)
ABIKO Yoshimitsu  日本大学, 歯学部, 教授 (70050086)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords歯周病 / 歯周組織再生 / ポストゲノム / トランスクリプトーム / FGF-2
Research Abstract

Transcriptome analysis of FGF-2-induced periodontal regeneration in beagle model revealed that several genes (PLXNC1, SMOC1, SMOC2, TNS3, NPNT, SPON1, WDHD1, etc.) can play important roles in osteogenic differentiation of mesenchymal stem cells. In addition, periodontal ligament specific splicing isoform of Periostin was found. On the other hand, PLAP-1, periodontal ligament specific molecule, has an asparagine acid repeat polymorphism. Importantly, these molecular differences affected their abilities to regulate differentiation of periodontal ligament cells. These results suggest that these genes may play important roles in predicting outcomes of regenerative therapy for periodontal tissue.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (56 results)

All 2011 2010 2009 2008

All Journal Article (22 results) (of which Peer Reviewed: 16 results) Presentation (32 results) Book (2 results)

  • [Journal Article] Periodontal tissue regener ation by signalling molecule(s)-What role does basic fibloblast growth facto r (FGF-2) have in periodontal therapy?2011

    • Author(s)
      村上伸也
    • Journal Title

      Periodontology 2000 56巻

      Pages: 188-208

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptome analysis of β-TCP implanted in dog mandible2011

    • Author(s)
      J Zhao、Y Abiko
    • Journal Title

      Bone 48巻

      Pages: 864-877

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3/Akt signaling and CD44/hyaluronan interaction2011

    • Author(s)
      Y Shimabukuro、T Hashikawa、M Yanagita、S Yamada、S Murakami
    • Journal Title

      Journal of Cellular Physiology 226巻

      Pages: 809-821

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal Tissue Regeneration by signalling molecule(s)-Does FGF-2innovate on the periodontal therapy?-2011

    • Author(s)
      Murakami S
    • Journal Title

      Periodontology 2000

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3/Akt signaling and CD44/hyaluronan interaction.2011

    • Author(s)
      Shimabukuro Y, Hashikawa T, Yanagita M, Yamada S, Murakami S, et al.
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226 Pages: 809-821

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of nicotine on the cytodifferentiation of murine periodontal ligament cells2010

    • Author(s)
      M Yanagita、S Yamada、S Murakami
    • Journal Title

      Oral Diseases 16巻

      Pages: 812-817

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of concomitant use of fibroblast growth factor (FGF)-2 with beta-tricalcium phosphate (β-TCP) on the beagle dog 1-wall periodontal defect model2010

    • Author(s)
      J Anzai、S Murakami
    • Journal Title

      Biochemical and Biophysical Research Communications 403巻

      Pages: 345-350

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of mechanical stress-induced glutamate signaling-associated molecules in cytodifferentitation of periodontal ligament cells2010

    • Author(s)
      C Fujihara、S Yamada、S Murakami
    • Journal Title

      The journal of biological chemistry 285巻

      Pages: 28286-28297

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical stress-induced glutamate sinahng-associated molecules in cytodifferentiation of periodontal ligament cells.2010

    • Author(s)
      Fujihara C, Murakami S, et al.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: VOL285 Pages: 28286-28297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of nicotine on the cytodifferentiation of murine periodontai ligament cells.2010

    • Author(s)
      Yanagita M, Yamada S, Murakami S, et al.
    • Journal Title

      Oral Diseases

      Volume: VOL16 Pages: 812-817

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of concomitant use of fibroblast growth factor (FGF)-2 with beta-tricalcium phosphate (β-TCP) on the beagle dog 1-wall periodontal defect model.2010

    • Author(s)
      Anzai J, Murakami S, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 403 Pages: 345-350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞増殖因子2009

    • Author(s)
      村上伸也
    • Journal Title

      季刊・歯科医療 23巻

      Pages: 24-28

    • Related Report
      2010 Final Research Report
  • [Journal Article] 歯周組織再生療法の現状と将来展望2009

    • Author(s)
      村上伸也
    • Journal Title

      綜合臨床 58巻

      Pages: 130-135

    • Related Report
      2010 Final Research Report
  • [Journal Article] The use of Biologic Medeators and Tissue Engi neering in Dentistry2009

    • Author(s)
      RT. Kao、S Murakami
    • Journal Title

      Periodontology 2000 50巻

      Pages: 127-153

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The use of Biologic Mediators and Tissue Engineering in Dentistry2009

    • Author(s)
      RT.Kao
    • Journal Title

      Peridontology 2000 50

      Pages: 127-153

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周組織再生療法の現状と将来展望2009

    • Author(s)
      村上伸也
    • Journal Title

      綜合臨床 58

      Pages: 130-135

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 細胞増殖因子2009

    • Author(s)
      村上伸也
    • Journal Title

      季刊・歯科医療 23

      Pages: 24-28

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The use of Biologic Medeators and Tissue Engineering inDentistry2009

    • Author(s)
      RT. Kao, et al
    • Journal Title

      Periodontology 2000 (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLAP-1:periodontal ligament specific molecule2008

    • Author(s)
      S Yamada
    • Journal Title

      J. Japanese Dental Science review 44巻

      Pages: 137-144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯周組織再生の現状と将来の展望再生医学のいま-基礎研究から臨床への展開に向けて-2008

    • Author(s)
      村上伸也
    • Journal Title

      治療 90巻

      Pages: 609-616

    • Related Report
      2010 Final Research Report
  • [Journal Article] 歯周組織再生の現状と将来の展望再生医学のいま -基礎研究から臨床への展開に向けて-2008

    • Author(s)
      村上伸也 ら
    • Journal Title

      治療 90

      Pages: 609-616

    • Related Report
      2008 Annual Research Report
  • [Journal Article] PLAP-1 : periodontal ligament specific molecule.2008

    • Author(s)
      S. Yamada, et al
    • Journal Title

      J. Japanese Dental Science review 44

      Pages: 137-144

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯周治療の近未来-その理論と臨床-2010

    • Author(s)
      村上伸也
    • Organizer
      第62回近畿北陸地区歯科医学大会
    • Place of Presentation
      マイドームおおさか(大阪)
    • Year and Date
      2010-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal tissueregeneration by basic fibroblast growthfactor (FGF-2)2010

    • Author(s)
      村上伸也
    • Organizer
      第12回台湾歯周病学会
    • Place of Presentation
      高雄(台湾)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal tissue regeneration by basic fibroblast growth factor (FGF-2)2010

    • Author(s)
      村上伸也
    • Organizer
      第12回台湾歯周病学会
    • Place of Presentation
      高雄(台湾)(招待講演)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gene polymorphism in PLAP-1/asporin regulates mineralization of periodontal ligament cells.2010

    • Author(s)
      Kajikawa T、 Yamada S、Murakami S
    • Organizer
      88th International Association of Dental Research
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal regeneration by FGF-22010

    • Author(s)
      村上伸也
    • Organizer
      Joint Symposium of University Leeds and Osaka University
    • Place of Presentation
      Leeds (UK)
    • Year and Date
      2010-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal regeneration by FGF-22010

    • Author(s)
      村上伸也
    • Organizer
      Joint Symposium of University Leeds and Osaka University
    • Place of Presentation
      リーズ大学(英国)(招待講演)
    • Year and Date
      2010-07-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] FGF-2 は歯周組織再生療法に変革をもたらすか2010

    • Author(s)
      村上伸也
    • Organizer
      日本臨床歯周病学会第28回年次大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Final Research Report
  • [Presentation] FGF-2は歯周組織再生療法に変革をもたらすか2010

    • Author(s)
      村上伸也
    • Organizer
      第28回日本臨床歯周病学会年次大会
    • Place of Presentation
      国立京都国際会館(京都)(招待講演)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] What role does FGF-2 have inperiodontal regeneration?2010

    • Author(s)
      村上伸也
    • Organizer
      2010年韓国歯周病学会春季学術大会
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2010-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] What role does FGF-2 have in periodontal regeneration?2010

    • Author(s)
      村上伸也
    • Organizer
      2010年韓国歯周病学会春季学術大会
    • Place of Presentation
      ソウル(韓国)(招待講演)
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規歯根膜特異的PeriostinアイソフォームType IIの機能解析2010

    • Author(s)
      田内拓史、山田聡、村上伸也
    • Organizer
      第53回日本歯周病学会春季学術大会
    • Place of Presentation
      盛岡市民文化ホール(盛岡)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトPLAP-1アスパラギン酸連続配列が歯根膜細胞の石灰化に及ぼす影響について2010

    • Author(s)
      梶川哲宏、山田聡、村上伸也
    • Organizer
      第53回日本歯周病学会春季学術大会
    • Place of Presentation
      盛岡市民文化ホール(盛岡)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] FGF-2による歯周組織再生-現状と将来展望2010

    • Author(s)
      村上伸也
    • Organizer
      第8回歯科骨粗鬆症研究会
    • Place of Presentation
      東京医科歯科大学歯学部4階特別講堂(東京)
    • Year and Date
      2010-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] FGF-2による歯周組織再生-現状と将来展望-2010

    • Author(s)
      村上伸也
    • Organizer
      第8回歯科骨粗鬆症研究会
    • Place of Presentation
      東京医科歯科大学(東京)(招待講演)
    • Year and Date
      2010-04-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 塩基性線維芽細胞増殖因子(FGF-2)を用いた新規歯周組織再生療法の確立2009

    • Author(s)
      村上伸也
    • Organizer
      第27回日本ヒト細胞学会学術集会
    • Place of Presentation
      東京慈恵会医科大学大学1館(東京)
    • Year and Date
      2009-08-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal tissue regeneration using FGF-22009

    • Author(s)
      村上伸也
    • Organizer
      中国牙周学会: Chinese Society of Periodontology
    • Place of Presentation
      南寧(中国)
    • Year and Date
      2009-08-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal tissue regeneration using FGF-22009

    • Author(s)
      Shinya Murakami
    • Organizer
      Chinese Society of Periodontology
    • Place of Presentation
      Nanning中国
    • Year and Date
      2009-08-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯周組織再生療法の現状と未来2009

    • Author(s)
      村上伸也
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織再生療法の現状と未来2009

    • Author(s)
      村上伸也
    • Organizer
      第27回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of a novel isoform of Periostin isolated from human periodontal ligament2009

    • Author(s)
      田内拓司、山田聡、村上伸也
    • Organizer
      第9回国際炎症学会(The 9th World Congress on Inflammation)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2009-07-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織再生療法の近未来を展望する2009

    • Author(s)
      村上伸也
    • Organizer
      第47回日本小児歯科学会大会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪)
    • Year and Date
      2009-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織再生療法の未来予測2009

    • Author(s)
      村上伸也
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2009-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織再生医療の未来予測2009

    • Author(s)
      村上伸也
    • Organizer
      日本再生医療学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2009-03-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 塩基性線維芽細胞増殖因子(FGF-2)を用いた新規歯周組織再生療法2009

    • Author(s)
      村上伸也
    • Organizer
      第28回日本口腔インプラント学会近畿北陸支部学術大会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-01-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal tissue regeneration by basic fibroblast growth factor(FGF-2)2008

    • Author(s)
      村上伸也
    • Organizer
      国際歯科研究学会(IADR)韓国部会(KADR)学術大会
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2008-12-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Periodontal tissue regeneration by FGF-22008

    • Author(s)
      村上伸也
    • Organizer
      国際歯科研究学会韓国部会(KADR)
    • Place of Presentation
      韓国国際展示場(韓国ソウル)
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯根膜特異的Periostinアイソフォームは歯根膜細胞の硬組織形成分化を促進する2008

    • Author(s)
      田内拓司、山田聡、柳田学、橋川智子、村上伸也
    • Organizer
      日本歯科保存学会2008年度秋季学術大会(第129回)
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2008-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 塩基性線維芽細胞増殖因子(FGF-2)を用いた新規歯周組織再生療法の確立にむけて2008

    • Author(s)
      村上伸也
    • Organizer
      日本再生歯科医学会
    • Place of Presentation
      日本歯科大学生命歯学部(東京都千代田区)
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 塩基性線維芽細胞増殖因子(FGF-2)を用いた新規歯周組織再生療法の確立に向けて2008

    • Author(s)
      村上伸也
    • Organizer
      第6回日本再生歯科医学会学術大会
    • Place of Presentation
      日本歯科大学生命歯学部九段ホール(東京)
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織再生療法の近未来を探る2008

    • Author(s)
      村上伸也
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル第1会場コスモスホール(東京)
    • Year and Date
      2008-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 歯周組織再生療法の近未来を探る2008

    • Author(s)
      村上伸也
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] PLAP-1/asporin Antagonizes BMP-2 Function Through LRR-52008

    • Author(s)
      山田聡、村上伸也
    • Organizer
      86th General Session of the IADR
    • Place of Presentation
      Toronto (Canada)
    • Year and Date
      2008-07-03
    • Related Report
      2010 Final Research Report
  • [Book] 先端歯科医学のカッティングエッジ2008

    • Author(s)
      村上伸也
    • Publisher
      大阪大学出版会
    • Related Report
      2010 Final Research Report
  • [Book] 先端歯科医学のカッティング エッジ2008

    • Author(s)
      村上伸也 ら
    • Publisher
      大阪大学出版会
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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