| Project/Area Number |
20404006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Tetsuya 北海道医療大学, 薬学部, 准教授 (10133216)
KOTAKI Yuichi 北里大学, 海洋生命科学部, 准教授 (30113278)
MATSUBARA Futoshi 第一薬科大学, 教授 (60368975)
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| Co-Investigator(Renkei-kenkyūsha) |
KOGA Nobuyuki 中村学園大学, 栄養科学部, 教授 (80136514)
OHTA Chiho 中村学園大学, 栄養科学部, 講師 (80271435)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 天然臭素化合物 / 海藻 / 食物連鎖 / 生物濃縮 / Hydroxy-PBDE / メチル化 / 環境動態 / 海綿 / hydroxy-PBDE / 培養 / 生産菌 / 海洋哺乳動物 / イタチザメ / methoxy PBDE / ハロゲン化ビピロール |
|---|
| Research Abstract |
In Asia-Pacific food web, we found that natural organobromine compounds are produced by some specific species of marine algae and sponges. We developed the LC/MS/MS method for screening of dihydroxy-PBDEs in sponges from Palau. In thorny oyster from the Philippines, naturally produced hydroxy-PBDEs were O-methylated with growth to the corresponding methoxy-PBDEs. In bivalves from Vietnam, halogenated biphenols(i. e. Br_3Cl-and Br_2Cl_2-analogs) that show antibacterial activities, were isolated. These secondary metabolites are accumulated in the higher organisms via food chain and also anticipated as lead compounds for bioactive medicines.
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