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The origin and genome diversity of retroviruses causing neurological disorders

Research Project

Project/Area Number 20405039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

OCHIAI Kenji  北海道大学, 大学院・獣医学研究科, 准教授 (80214162)

Co-Investigator(Kenkyū-buntansha) OHASHI Kazuhiko  北海道大学, 大学院・獣医学研究科, 教授 (90250498)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsグリオーマ / 鶏 / 中枢神経系腫瘍 / 分子系統進化 / トリ白血病ウイルス / レトロウイルス / トリのグリオーマ / トリ / トリ血病ウイルス
Research Abstract

Fowl glioma is caused by fowl glioma-inducing virus (FGV), belonging to subgroup A of avian leucosis virus (ALV-A). To clarify how and where FGV emerged, the prevalence of FGV in European, Asian and Japanese native chickens were examined and the viral genome of the isolates were analyzed. The results suggest that FGV is likely to have appeared in Japanese fowls in Japan without a relationship to the past fowl glioma found in Western countries, and that FGV and FGV vatriants still spread in Japanese fowls, showing genome diversity mainly based on the recombination between these strains and avian endogenous/exogenous viruses.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (12 results) Remarks (6 results)

  • [Journal Article] Epidemiological study of fowl glioma-inducing virus in chickens in Asia and Germany2012

    • Author(s)
      Ochi, A., Ochiai, K., et al., 他14名, 2番目
    • Journal Title

      Avian Pathol

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma2012

    • Author(s)
      Ochi, A., Ochiai, K., et al., 他4名, 2番目
    • Journal Title

      Avian Dis

      Volume: 56(1) Pages: 35-43

    • URL

      http://www.bioone.org/doi/ful1/10.1637/9830-060711-Reg.1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenicity of avian leukosis viruses related to fowl glioma-inducing virus2012

    • Author(s)
      Nakamura, S., Ochiai, K., et al., 他4名, 2番目
    • Journal Title

      Avian Pathol

      Volume: 40(5) Pages: 499-505

    • URL

      http://dx.doi.org/10.1080/03079457.2011.605783

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma2012

    • Author(s)
      Ochi, A., 他5名
    • Journal Title

      Avian Diseases

      Volume: 56 Issue: 1 Pages: 35-43

    • DOI

      10.1637/9830-060711-reg.1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiological study of fowl glioma-inducing virus in chickens in Asia and Germany2012

    • Author(s)
      Ochi, A., 他15名
    • Journal Title

      Avian Pathology

      Volume: 41 Issue: 3 Pages: 299-309

    • DOI

      10.1080/03079457.2012.684373

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenicity of avian leucosis viruses related to fowl glioma-inducing virus2011

    • Author(s)
      Nakamura, S., 他5名
    • Journal Title

      Avian Pathology

      Volume: 40 Issue: 5 Pages: 499-505

    • DOI

      10.1080/03079457.2011.605783

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic myelolipoma and amyloidosis with osseous metaplasia in a Swan Goose (Anser cygnoides)2009

    • Author(s)
      Hatai, H., Ochiai, K., et al, 他6名, 2番目
    • Journal Title

      J. Comp. Pathol

      Volume: 141(4) Pages: 260-264

    • URL

      http://dx.doi.org/10.1016/j.jcpa.2009.05.005

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of avian leukosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts2009

    • Author(s)
      Hatai, H., Ochiai, K., et al., 他1名2番目
    • Journal Title

      J. Vet. Diagn. Invest

      Volume: 21(4) Issue: 4 Pages: 519-522

    • DOI

      10.1177/104063870902100415

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic myelolipoma and amyloidosis with osseous metaplasia in a Swan Goose (Anser cygnoides)2009

    • Author(s)
      Hatai, H., Ochiai, K., et al.
    • Journal Title

      J.Comp.Pathol. 141(4)

      Pages: 260-264

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Detection of avian leucosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts2009

    • Author(s)
      Hatai, H., Ochiai, K., et al.
    • Journal Title

      J.Vet.Diagn.Invest. 21(4)

      Pages: 519-522

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Hepatic myelolipoma and amyloidosis with osseous metaplasia in a Swan Goose(Anser cygnoides)2009

    • Author(s)
      Hatai, H., Ochiai, K., et al., 他6名
    • Journal Title

      J.Comp.Pathol. 141(4)

      Pages: 260-264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of avian leukosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts.2009

    • Author(s)
      Hatai, H., Ochiai, K., et al., 他1名
    • Journal Title

      J.Vet.Diagn.Invest. 21(4)

      Pages: 519-522

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fowl glioma-inducing virus in chickens of zoological gardens in Japan and nuculeotide variation in the env gene2008

    • Author(s)
      Hatai, H., Ochiai, K., et al. 他6名, 2番目
    • Journal Title

      J. Vet. Med. Sci

      Volume: 70(5) Pages: 469-474

    • URL

      http://dx.doi.org/10.1292/jvms.70.469

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fowl glioma-inducing virus in chickens of zoological gardens in Japan and nucleotide variation in the env gene2008

    • Author(s)
      Hatai, H., Ochiai, K, et.al., 他6名
    • Journal Title

      J. Vet. Med. Sci. 70(5)

      Pages: 469-474

    • NAID

      130000446953

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経病原性トリレトロウイルスの出現経緯2012

    • Author(s)
      越智章仁ら
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ,大宮
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本鶏におけるトリの神経膠腫誘発ウイルスの感染状況2012

    • Author(s)
      中村小百合ら
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ,大宮
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経病原性トリレトロウイルスの出現経緯2012

    • Author(s)
      越智章仁, 他6名
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(大宮)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] トリレトロウイルス感染鶏に認められた心筋の形態異常2011

    • Author(s)
      藪下広樹ら
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      東京農工大学,東京
    • Year and Date
      2011-04-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 野外で発生した鶏の多発性神経周膜腫の病理学的ならびに疫学的検索2011

    • Author(s)
      光廣直貴ら
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      東京農工大学,東京
    • Year and Date
      2011-04-01
    • Related Report
      2011 Final Research Report
  • [Presentation] トリレトロウイルス感染鶏に認められた心筋の形態異常2011

    • Author(s)
      藪下広樹, 他6名
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      東京農工大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 野外で発生した鶏の多発性神経周膜腫の病理学的ならびに疫学的検索2011

    • Author(s)
      光廣直貴, 他6名
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      東京農工大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 九州地方の一日本鶏群で見つかった神経病原性レトロウイルス2010

    • Author(s)
      越智章仁ら
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      日本獣医生命科学大学,東京
    • Year and Date
      2010-03-27
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 新たに分離された神経膠腫誘発レトロウイルスの分子系統解析と神経病原性の比較2010

    • Author(s)
      中村小百合ら
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      日本獣医生命科学大学,東京
    • Year and Date
      2010-03-27
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 九州地方の-日本鶏群で見つかった神経病原性レトロウイルス2010

    • Author(s)
      越智章仁, 落合謙爾, 他8名
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      日本獣医生命科学大学,東京
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] アトキソプラズマ症の病態解析2008

    • Author(s)
      森真依子ら
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンションセンターサミット(シーガイア),宮崎
    • Year and Date
      2008-09-24
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] アトキソプラズマ症の病態解析2008

    • Author(s)
      森真依子, 落合謙爾, 他8名
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンションセンターサミット(シーガイア), 宮崎
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/comp-pathol/daimoku-glil.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/comp-pathol/daimoku-glil.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/comp-pathol/daimoku-glil.html

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/comp-pathol/daimoku-glil.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/comp-pathol/daimoku-glil.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.vetmed.hokudai.ac.jp/organization/comp-pathol/daimoku-glil.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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