| Project/Area Number |
20405042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUMAGAI Susumu The University of Tokyo, 大学院・農学生命科学研究科, 教授 (60109965)
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| Co-Investigator(Kenkyū-buntansha) |
KONISHI Yoshiko 国立医薬品食品衛生研究所, 衛生微生物部, 部長 (10195761)
SAKUDA Shohei 東京大学, 大学院・農学生命科学研究科, 准教授 (80192087)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKATORI Kousuke NPO法人カビ相談センター, 理事長
PRAPEUK Tangmunkhong Kasetsart University, Faculty of Veterinary Medicine, Associate Professor
AMNART Poapolathep Kasetsart University, Faculty of Veterinary Medicine, Associate Professor
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | アフラトキシン / ゼアラレノン / タイ / 家畜 / 分解 |
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| Research Abstract |
In order to find metabolic detoxification by micro-organisms in soil of Thailand, where heavy contamination with mycotoxins has been observed, bacteria and fungi isolated from Cassava farms in Thailand were examined for their activities to metabolize aflatoxin, ochratoxin A and zearalenone. The result demonstrated some bacteria and fungi to metabolize aflatoxin B1 and ochratoxin A. Feces of horse, sheep and pig living in the central region of Thailand, and anaerobic bacteria isolated from the feces, were also examined for their metabolic activities toward mycotoxins, but clear metabolism was not found. With regard to animal tissues, a possible conversion of aflatoxin B2 to B1 by the liver tissues from various animals was suggested. Also tissues of various organs of goat were demonstrated to metabolize zearalenone to alpha-and beta-zearalenols.
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