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Current status and co-infection of Lyme disease borrelia and human granulocytic Anaplasma in Eurasia.

Research Project

Project/Area Number 20406011
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Bacteriology (including Mycology)
Research InstitutionChiba Institute of Science

Principal Investigator

MASUZAWA Toshiyuki  Chiba Institute of Science, 薬学部, 教授 (10181645)

Co-Investigator(Kenkyū-buntansha) OHASHI Norio  静岡県立大学, 食品栄養科学部, 教授 (10169039)
KADOSAKA Teruki  愛知医科大学, 医学部, 講師 (90109760)
OKAMOTO Yoshihiro  千葉科学大学, 薬学部, 准教授 (40261036)
FUKUI Takashi  千葉科学大学, 薬学部, 助教 (10453482)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywordsアナプラズマ / ライム病 / ボレリア / マダニ / マダニ媒介性感染症 / Anaplasma / Borrelia / Ixodes / ダニ媒介性感染症
Research Abstract

Distribution of Anaplasma phagocytophilum and coinfection of A. phagocytophilum and Lyme disease Borrelia spp. in Turkey, Irkutsk, and Taiwan were examined. Both pathogens were detected from tick collected in Turkey and Irkutsk. The co-infection rate in ticks were less than 5%. P44 protein sequences of A. phagocytophilum detected in Turkey were in the same genetic lineage of these detected from Serbia and Moscow in Russia. On the other hand, some of the protein detected in Irkutsk were similar to those from ticks in Japan. A. phagocytophilum and Anaplasma bovis were detected from rodents in Taiwan.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 8 results) Presentation (10 results) Book (1 results)

  • [Journal Article] Multilocus sequence typing implicates rodents as main reservoir host of human-pathogenic Borrelia garinii in Japan.2011

    • Author(s)
      Ai Takano, Minoru Nakao, Toshiyuki Masuzawa, Nobuhiro Takada, Yasuhiro Yano, Fubito Ishiguro, Hiromi Fujita, Takuya Ito, Xiaohang Ma, Yozaburo Oikawa, Fumihiko Kawamori, Kunihiko Kumagai, Toshiyuki Mikami, Nozomu Hanaoka, Shuji Ando, Naoko Honda, Kyle Tayor, Toshio Tsubota, Satoru Konnai, Haruo Watanabe, Makoto Ohnishi, Hiroki Kawabata
    • Journal Title

      Journal of Clinical Microbiology 49

      Pages: 2035-2039

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular detection of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes ricinus ticks from Istanbul metropolitan area and rural Trakya (Thrace) region of North western Turkey.2011

    • Author(s)
      Ece Sen, Yoshiyuki Uchishima, Yoshihiro Okamoto, Takashi Fukui, Teruki Kadosaka, Norio Ohashi, Toshiyuki Masuzawa
    • Journal Title

      Ticks and tick-borne diseases 2

      Pages: 94-98

    • Related Report
      2010 Final Research Report
  • [Journal Article] Potential infectivity of Anaplasma phagocytophilum strains in Ixodes ricinus ticks from Serbia.2010

    • Author(s)
      Snezana Tomanovic, Zeljko Radulovic, Toshiyuki Masuzawa, Marija Milutinovic, Ljubisa Stnisavljevic
    • Journal Title

      Acta Veterinaria Hungarica 58

      Pages: 231-242

    • Related Report
      2010 Final Research Report
  • [Journal Article] Coexistence of emerging bacterial pathogens in Ixodes ricinus ticks in Serbia.2010

    • Author(s)
      Snezana Tomanovic, Zeljko Radulovic, Toshiyuki Masuzawa, Marija Milutinovic
    • Journal Title

      Parasite 17

      Pages: 211-217

    • Related Report
      2010 Final Research Report
  • [Journal Article] Potential infectivity of Anaplasma phagocytophilum strains in Ixodes ricinus ticks from Serbia.2010

    • Author(s)
      Snezana Tomanovic, et al.
    • Journal Title

      Acta Veterinaria Hungarica

      Volume: 58 Pages: 231-242

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of emerging bacterial pathogens in Ixodes ricinus ticks in Serbia.2010

    • Author(s)
      Snezana Tomanovic, et al.
    • Journal Title

      Parasite

      Volume: 17 Pages: 211-217

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular detection of Anaplasma phagocytophilum and Borrelia burg dorferi in Ixodes ricinus ticks from Istanbul metropolitan area and rural Trakya (Thrace) region of North western Turkey.2010

    • Author(s)
      Ece Sen, et al.
    • Journal Title

      Ticks and tick-borne diseases

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural analysis of a p44/msp2 expression site of Anaplasma phagocytophilum in naturally infected ticks in Japan.2009

    • Author(s)
      Wuritu, Ozawa Y, Gaowa, Kawamori F, Masuda T, Masuzawa T, Fujita H, Ohashi N.
    • Journal Title

      Journal of Medical Microbiology. 58

      Pages: 1638-1644

    • Related Report
      2010 Final Research Report
  • [Journal Article] Assessment of rate of infection with agents of bacterial infections in ticks captured on one of the Moscow park terrains (in Russian)2009

    • Author(s)
      Kharitonenkov IG, Masuzawa T, Okamoto I, Fukui T, Trifonov IV, Reznikov IuP, Rumiantsev AG.
    • Journal Title

      Zh Mikrobiol Epidemiol Immunobiol. 3

      Pages: 14-17

    • Related Report
      2010 Final Research Report
  • [Journal Article] Assessment of rate of infection with agents of bacterial infections in ticks captured on one of the Moscow park terrains(in Russian).2009

    • Author(s)
      Igor G.Kharitonenkov
    • Journal Title

      Zh Mikrobiol Epidemiol Immunobiol 3

      Pages: 175-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural analysis of a p44/msp2 expression site of Anaplasma phagocytophilum in naturally infected ticks in Japan.2009

    • Author(s)
      Wuritu
    • Journal Title

      Journal of Medical Microbiology 58

      Pages: 1638-1644

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of emerging bacterial pathogens in Ixodes ricinus ticks in Serbia2009

    • Author(s)
      Tomanovic S
    • Journal Title

      Parasite (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Francisella tularensis and their co-infections in host-seeking Ixodes ricinus ticks collected in Serbia.2008

    • Author(s)
      Marija Milutinovic
    • Journal Title

      Experimental and Applied Acarology 74

      Pages: 5086-5092

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province(Russia)-a sympatric region for both tick species.2008

    • Author(s)
      Toshiyuki Masuzawa
    • Journal Title

      Journal of Medical Microbiology 57

      Pages: 986-991

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Anaplasma phagocytophilum from wild boars and deer in Japan.

    • Author(s)
      Toshiyuki Masuzawa, Yoshiyuki Uchishima, Takashi Fukui, Yoshihiro Okamoto, Maki Muto, Nobuo Koizumi, Akio Yamada
    • Journal Title

      Japanese Journal of Infectious Diseases in press

    • NAID

      40018924986

    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular detection of tick-borne pathogens, Anaplasma phagocytophilum and Borrelia burgdorferi, from vector tick, Ixodes ricinus, collected in the Istanbul metropolitan area and rural Trakya (Thrace) region of Turkey.2011

    • Author(s)
      Toshiyuki Masuzawa, Ece Sen, Yoshiyuki Uchishima, Yoshihiro Okamoto, Takashi Fukui, Teruki Kadosaka, Norio Ohashi
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-07
    • Related Report
      2010 Final Research Report
  • [Presentation] イルクーツクとトルコにおけるヒト顆粒球アナプラズマとライム病ボレリアの共感染2010

    • Author(s)
      増澤俊幸、内島祥由紀、岡本能弘、福井貴史、Ece Sen、Maxim Khasnatinov
    • Organizer
      第54回日本薬学会関東支部会
    • Place of Presentation
      八王子
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 多領域DNA配列解析によって推定された国内におけるライム病ボレリア病原体Borrelia gariniiの維持・伝播経路2010

    • Author(s)
      川端寛樹, 高野愛, 伊東拓也, 石畝史, 高田伸弘, 中尾稔, 増沢俊幸, 藤田博己, 渡邉治雄, 大西真
    • Organizer
      第56回日本寄生虫学会・日本衛生動物学会北日本支部合同大会
    • Place of Presentation
      札幌
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] トルコとイルクーツクにおけるヒト顆粒球アナプラズマ、並びにライム病ボレリアの検出2010

    • Author(s)
      内島祥由紀、増澤俊幸、岡本能弘、福井貴史、角坂照貴、大橋典男、Ece Sen、Maxim Khasnatinov
    • Organizer
      第22回微生物シンポジウム
    • Place of Presentation
      高槻
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] トルコのアナプラズマ検出2010

    • Author(s)
      内島祥由紀、増澤俊幸、岡本能弘、福井貴史、角坂照貴、Ece Sen
    • Organizer
      第18回ダニと疾患のインターフェースに関するセミナー
    • Place of Presentation
      佐渡市
    • Year and Date
      2010-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] トルコ国内からの人獣共通感染症病原微生物の検出2010

    • Author(s)
      内島祥由紀、増澤俊幸、岡本能弘、福井貴史、角坂照貴、Ece Sen
    • Organizer
      第47回レプトスピラシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Multi-locussequence typing法による国内野生鳥類由来ボレリアと北海道患者由来ボレリアの遺伝子型別解析2009

    • Author(s)
      川端寛樹, 武藤麻紀, 高野愛, 小笠原由美子, 藤田博己, 鶴見みや古, 増沢俊幸, 宮本健司, 渡邉治雄
    • Organizer
      第55回日本衛生動物学会北日本支部大会
    • Place of Presentation
      帯広
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] マダニ媒介性感染症病原体(ライム病ボレリアとヒト顆粒球アナプラズマ)の地理的分布と多様性2009

    • Author(s)
      増澤俊幸、岡本能弘、岡野江里子、川谷慶太
    • Organizer
      第21回微生物シンポジウム
    • Place of Presentation
      福山
    • Year and Date
      2009-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] トルコのIxodes ricinusからのAnaplasma phagocytophilumの検出2009

    • Author(s)
      内島祥由紀、Ece Sen、角坂照貴、大橋典男、岡本能弘、福井貴史、増澤俊幸
    • Organizer
      第17回ダニと疾患のインターフェースに関するセミナー
    • Place of Presentation
      大野
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Detection of the Borrelia burgdorferi sense lato and Anaplasma phagocytophilum in host-seeking adult Ixodes ricinus ticks collected in Serbia.2008

    • Author(s)
      Keita Kawatani, Toshiyuki Masuzawa, Marija Milutinovic, Takashi Fukui, Yoshihiro Okamoto
    • Organizer
      International Crisis Management Symposium on CBRN and Emerging Infectious Diseases(Abt.p.72)
    • Place of Presentation
      Choshi, Japan
    • Related Report
      2010 Final Research Report
  • [Book] 人獣共通感染症 アナプラズマ症、エーリキア症2011

    • Author(s)
      増澤俊幸、福井貴史
    • Publisher
      医薬ジャーナル
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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