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Evaluation of the effect of rotavirus vaccine on severe diarrhea and circulating rotavirus strains in Nepal

Research Project

Project/Area Number 20406013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionNagasaki University

Principal Investigator

NAKAGOMI Osamu  長崎大学, 大学院・医歯薬学総合研究科, 教授 (70143047)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywordsロタウイルス / ワクチン / 遺伝子型 / 分子疫学 / 流行株 / G12 / ネパール / ノロウイルス / 下痢症 / 血清型
Research Abstract

Virtually all children in the world are infected with rotavirus by the age of 5 years, but the outcome of infection differs considerably between developed and developing countries. Nepal is one of such countries where the burden of rotavirus disease is very high. In 2009, the World Health Organization issued a universal immunization of children with rotavirus vaccine, and Nepal is expected to introduce rotavirus vaccine sooner or later. This study revealed a substantial burden of rotavirus and norovirus diarrhea in Nepal, and described the molecular epidemiologic features of these gastroenteritis viruses on which the impact of rotavirus vaccine would be measured. This study also clarified how globally unusual G12P[ 6] rotavirus strains, yet very common in Nepal, evolved over time.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2012 2011 2010 2009 2008

All Journal Article (17 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Book (3 results)

  • [Journal Article] The occurrence of amino acid substitutions D96N and S242N in VP7 of emergent G2P[ 4] rotaviruses in Nepal in 2004-2005 : a global and evolutionary perspective2011

    • Author(s)
      Doan YH, Nakagomi T, Cunliffe NA, Pandey BD, Sherchand JB, Nakagomi O
    • Journal Title

      Arch Virol

      Volume: 156(11) Pages: 1969-78

    • Related Report
      2011 Final Research Report
  • [Journal Article] The occurrence of amino acid substitutions D96N and S242N in VP7 of emergent G2P[4] rotaviruses in Nepal in 2004-2005 : a global and evolutionary perspective2011

    • Author(s)
      Doan YH
    • Journal Title

      Arch Virol

      Volume: 156 Issue: 11 Pages: 1969-1978

    • DOI

      10.1007/s00705-011-1083-z

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and molecular epidemiology of rotavirus and norovirus infections in Libyan children2011

    • Author(s)
      Abugalia M
    • Journal Title

      J Med Virol

      Volume: 83 Issue: 10 Pages: 1849-1856

    • DOI

      10.1002/jmv.22141

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection and molecular characterisation of rotavirus and norovirus infections in Jordanian children with acute gastroenteritis2011

    • Author(s)
      Kaplan NM
    • Journal Title

      Arch Virol

      Volume: 156 Issue: 8 Pages: 1477-1480

    • DOI

      10.1007/s00705-011-0996-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Global impact of rotavirus vaccines2010

    • Author(s)
      Tate JE, Patel MM, Steele AD, Gentsch JR, Payne DC, Cortese MM, Nakagomi O, Cunliffe NA, Jiang B, Neuzil KM, de Oliveira LH, Glass RI, Parashar UD
    • Journal Title

      Expert Rev Vaccines

      Volume: 9 Pages: 395-407

    • Related Report
      2011 Final Research Report
  • [Journal Article] ワクチンによるロタウイルスの感染制御2010

    • Author(s)
      中込治, 中込とよ子
    • Journal Title

      ウイルス

      Volume: 60 Pages: 33-48

    • NAID

      10027048889

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 新時代のワクチン戦略について考える:ロタウイルスワクチン2010

    • Author(s)
      中込とよ子, 中込治
    • Journal Title

      臨床検査

      Volume: 54 Pages: 1392-1399

    • Related Report
      2011 Final Research Report
  • [Journal Article] Reassortment of human rotavirus gene segments into G11 rotavirus strains.2010

    • Author(s)
      Matthijnssens J
    • Journal Title

      Emerg Infect Dis

      Volume: 16 Pages: 625-630

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ロタウイルスワクチン:わが国への導入の展望と課題2010

    • Author(s)
      中込治
    • Journal Title

      臨床とウイルス

      Volume: 38 Pages: 454-465

    • NAID

      10027748520

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Molecular Epidemiology of Rotavirus Diarrhea among Children Aged<5 Years in Nepal : Predominance of Emergent G12 Strains during 2 Years2009

    • Author(s)
      Sherchand JB, Nakagomi O, Dove W, Nakagomi T, Yokoo M, Pandey BD, Cuevas L, Hart CA, Cunliffe NA
    • Journal Title

      J Infect Dis

      Volume: 200(Suppl) Pages: 182-197

    • Related Report
      2011 Final Research Report
  • [Journal Article] Molecular epidemiology of rotavirus diarrhea among children aged<5 years in Nepal : predominance of emergent G12 strains during 2 years.2009

    • Author(s)
      Sherchand JB, Nakagomi O, Dove W, Nakagomi T, Yokoo M, Pandey BD, Cuevas L, Hart CA, Cunliffe NA.
    • Journal Title

      J Infect Dis 200(Suppl)

      Pages: 182-197

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] A critical review on a globally-licensed, live, orally-administrable, monovalent human rotavirus vaccine : Rotarix.2009

    • Author(s)
      Nakagomi T, Nakagomi O.
    • Journal Title

      Expert Opin Biol Ther 9

      Pages: 1073-86

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Molecular epidemiology of rotavirus diarrhea among children aged<5 years in Nepal : predominance of emergent G12 strains during 2 years.2009

    • Author(s)
      Sherchand JB
    • Journal Title

      Journal of Infectious Diseases 200(suppl)

      Pages: 182-197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 世界的に使われているロタウイルスワクチン2009

    • Author(s)
      中込とよ子
    • Journal Title

      臨床検査 53

      Pages: 111-116

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 世界的に使用されているロタウイルスワクチンのわが国における必要性2009

    • Author(s)
      中込とよ子
    • Journal Title

      臨床とウイルス 37

      Pages: 167-177

    • NAID

      10024951942

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ロタウイルスワクチンの現状と課題2008

    • Author(s)
      中込 治
    • Journal Title

      臨床とウイルス 36

      Pages: 159-169

    • NAID

      10024951406

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Issues with reducing the rotavirus-associated mortality by vaccination in developing countries2008

    • Author(s)
      Naghipour, M
    • Journal Title

      Vaccine 26

      Pages: 3236-3241

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] A global and evolutionary perspective of the G2 VP7 genes of rotavirus strains detected over the last 34 years2011

    • Author(s)
      Nakagomi O, Doan YH, Nakagomi T, Cunliffe NA
    • Organizer
      4th European Rotavirus Biology Meeting
    • Place of Presentation
      Reggio Calabria, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible implication of amino acid substitution D96N in the VP7 gene of G2P[ 4] strains emerging in Nepal and elsewhere in the context of the evolution of G2 strains2011

    • Author(s)
      Doan YH, Nakagomi T, Cunliffe NA, Pandey BD, Sherchand JB, Nakagomi O
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo, Convention Center
    • Related Report
      2011 Final Research Report
  • [Presentation] 地球規模で見たロタウイルスG2株の34年間にわたる分子進化学的変遷2011

    • Author(s)
      中込治, Doan YH, 中込とよ子
    • Organizer
      第65回日本細菌学会東北支部総会
    • Place of Presentation
      山形市
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible implication of amino acid substitution D96N in the VP7 gene of G2P[4] strains emerging in Nepal and elsewhere in the context of the evolution of G2 strains2011

    • Author(s)
      Doan YH
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo (Hokkaido)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ロタウイルスの遺伝子型特異的免疫に関する分子疫学的解析2010

    • Author(s)
      中込とよ子, 中込治, 有澤孝吉
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-11-07
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Zoonotic origin of rotaviruses as revealed by the genome analysis2010

    • Author(s)
      Nakagomi, O
    • Organizer
      Emerging and Re-emerging Vector-Borne and Zoonotic Infectious Diseases in Southeast Asia Workshop
    • Place of Presentation
      Hanoi, Vietnam
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Zoonotic origin of rotaviruses as revealed by the genome analysis.2010

    • Author(s)
      Nakagomi O, Doan YH, Nakagomi T.
    • Organizer
      Emerging and Re-emerging Vector-Borne and Zoonotic Viral Infectious Diseases in Southeast Asia
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Phylogenetic analysis of G2P[4] strains with emerging importance after rotavirus vaccine introduction.2010

    • Author(s)
      Doan Y H, Nakagomi T, Nakagomi O.
    • Organizer
      Emerging and Re-emerging Vector-Borne and Zoonotic Viral Infectious Diseases in Southeast Asia
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Continued dominance in Nepal of G12P[6] rotavirus strains that are fully-heterotypic to currently licensed vaccines.2010

    • Author(s)
      Hoa T N T, Nakagomi T, Nakagomi O.
    • Organizer
      Emerging and Re-emerging Vector-Borne and Zoonotic Viral Infectious Diseases in Southeast Asia
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] ネパールに大規模出現した新興株G12P[6]ロタウイルスの分子疫学2008

    • Author(s)
      中込治, 中込とよ子
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2008-10-28
    • Related Report
      2010 Self-evaluation Report 2008 Annual Research Report
  • [Book] ロタウイルス感染症の世界の状況2012

    • Author(s)
      中込とよ子,中込治
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Final Research Report
  • [Book] ロタウイルス感染症の医療経済学2012

    • Author(s)
      中込治,中込とよ子
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Final Research Report
  • [Book] Manson's Tropical Diseases 22nd ed(Cook GC, Zumla AI eds)(Diarrhoea caused by viruses.)2009

    • Author(s)
      Hart CA, Cunliffe NA, Nakagomi O.
    • Publisher
      Saunders, Elsevier
    • Related Report
      2010 Self-evaluation Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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