• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Physiological status depending on particle size in workers at the nano-handling factor

Research Project

Project/Area Number 20406015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

ICHIHARA Sahoko  Mie University, 大学院・地域イノベーション学研究科, 准教授 (20378326)

Co-Investigator(Kenkyū-buntansha) HIRAKU Yusuke  三重大学, 大学院・医学系研究科, 講師 (30324510)
ICHIHARA Gaku  名古屋大学, 大学院・医学系研究科, 准教授 (90252238)
KOBAYASHI Takahiro  東京工業大学, 統合研究院, 特任教授 (50124342)
OMURA Seiichi  東京工業大学, 統合研究院, ソリューション研究員 (80462480)
Co-Investigator(Renkei-kenkyūsha) HISANAGA Naomi  愛知教育大学, 保健環境センター, 教授 (90111856)
SHIBATA Eiji  愛知医科大学, 大学院・医学系研究科, 教授 (90206128)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsナノ粒子 / 循環器疾患 / 心拍数 / リスク評価 / ナノ素材 / 心肺機能 / 粒子数 / 安全性 / ナノマテリアル / 酸化チタン / 酸化ストレス / 炎症 / 線維化
Research Abstract

The present study investigated possible respiratory and cardiovascular effects of titanium dioxide on the workers in Shanghai. The present study generated hypotheses that aggregation of particles might reduce nano-scaled particles by an absorption mechanism and that exposure to particle might increase the heart rate in workers handling titanium dioxide.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (86 results)

All 2011 2010 2009 2008 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (64 results) Book (1 results)

  • [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population.2011

    • Author(s)
      Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M.
    • Journal Title

      Eur J Hum Genet 19(3)

      Pages: 262-269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population.2011

    • Author(s)
      Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M.
    • Journal Title

      Eur J Hum Genet

      Volume: 19 Pages: 262-269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.2011

    • Author(s)
      Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han BG, Ahn Y, Lee M, Shin DJ, Lee JH, Jang Y.
    • Journal Title

      Atherosclerosis

      Volume: 215 Pages: 145-152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose- dependent neurologic abnormalities in workers exposed to 1-bromopropane.2010

    • Author(s)
      Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
    • Journal Title

      J Occup Environ Med 52(8)

      Pages: 769-777

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response.2010

    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
    • Journal Title

      Arterioscler Thromb Vasc Biol 30(8)

      Pages: 1553-1561

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane induced hepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Sai U, Kitoh J, Ichihara G.
    • Journal Title

      Toxicol Sci 115(2)

      Pages: 596-606

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters.2010

    • Author(s)
      Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
    • Journal Title

      Circ J 74(1)

      Pages: 163-170

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters.2010

    • Author(s)
      Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
    • Journal Title

      Circulation Journal

      Volume: 74 Pages: 163-170

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Sai U, Kitoh J, Ichihara G.
    • Journal Title

      Toxicological Science

      Volume: 115 Pages: 596-606

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response.2010

    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
    • Journal Title

      Arteriosclerosis Thrombosis and Vascular Biology

      Volume: 30 Pages: 1553-1561

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dose-Dependent Neurologic Abnormalities in Workers Exposed to 1-Bromopropane.2010

    • Author(s)
      Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 52 Pages: 769-777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains.2009

    • Author(s)
      Liu F, Ichiharhar S, Mohideen SS, Sai U, Kitoh J, Ichihara G.
    • Journal Title

      Toxicol Sci 112(1)

      Pages: 100-110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in neuro transmitter receptor expression levels in rat brain after 4-week exposure to 1- bromopropane.2009

    • Author(s)
      Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G.
    • Journal Title

      Neurotoxicology 30(6)

      Pages: 1078-1083

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ischemia-induced angiogene sis by benzo [a] pyrene in a manner depen dent on the aryl hydrocarbon receptor.2009

    • Author(s)
      Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
    • Journal Title

      Biochem Biophys Res Commun 381(1)

      Pages: 44-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of polymorphism of ABCB1 with obesity in Japanese individuals.2009

    • Author(s)
      Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Kojima T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y.
    • Journal Title

      Genomics 91(6)

      Pages: 512-516

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor2009

    • Author(s)
      Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
    • Journal Title

      Biochemical and Biophysical Research Communication 381

      Pages: 44-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane2009

    • Author(s)
      Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G.
    • Journal Title

      Neurotoxicology 10

      Pages: 1078-1083

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains2009

    • Author(s)
      Liu F, Ichihara S, Mohideen SS, Sai U, Kitoh J, Ichihara G.
    • Journal Title

      Toxicological Science 112

      Pages: 100-110

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters2009

    • Author(s)
      Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
    • Journal Title

      Circulation Journal 74

      Pages: 163-170

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo [a] pyrene in a manner dependent on the aryl hydrocarbon receptor.2009

    • Author(s)
      Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
    • Journal Title

      Biochem Biophys Res Commun (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proinflammatory gene polymorphisms and ischemic stroke.2008

    • Author(s)
      Yamada Y, Ichihara S, Nishida T.
    • Journal Title

      Curr Pharm Des 14

      Pages: 3590-3600

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The occu pational health survey on workers and nanoparticle numbers in the factory hand ling nano-titanium dioxide.2011

    • Author(s)
      Sahoko Ichihara, Weihua Li, Takahiro Kobayashi, Seiichi Omura, Yusuke Hiraku, Xuncheng Ding, Gaku Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxico logy
    • Place of Presentation
      Washington DC, USA(一般演題)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Genomics and proteomics analy sis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of meta bolic syndrome.2011

    • Author(s)
      Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro, Kuzuya, Gaku Ichihara, Sahoko Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA(一般演題)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Genomics and Proteomics Analysis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of metabolic syndrome.2011

    • Author(s)
      Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro, Kuzuya, Gaku Ichihara, Sahoko Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hyperphosphatemia and Hypozincemia Affect Peripheral Nervous System in SHR/NDmcr-cp, a Model of Metabolic Syndrome.2011

    • Author(s)
      Yuka Suzuki, Sahoko Ichihara, Ai Kato, Takahiro Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] The occupational health survey on workers and nanoparticle numbers in the factory handling nano-titanium dioxide.2011

    • Author(s)
      Sahoko Ichihara, Weihua Li, Takahiro Kobayashi, Seiichi Omura, Yusuke Hiraku, Xuncheng Ding, Gaku Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia in rat brain.2011

    • Author(s)
      Sahabudeen Sheik Mohideen, Sahoko Ichihara, Zhen Huang, Ling Zhang, Kaviarasan Subramanian, Junzo Kitoh, Gaku Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Exposure to 1-bromopropane Dedegenerates noradrenergic axons in the rat brain.2011

    • Author(s)
      Gaku Ichihara, Sahabudeen Sheik Mohideen, Sahoko Ichihara, Shoji Nakamura.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hyperphosphat emia and hypozincemia affect peripheral nervous system in SHR/NDmcr-cp, a model of meta bolic syndrome.2011

    • Author(s)
      Yuka Suzuki, Sahoko Ichihara, Ai Kato, Takahiro Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
    • Organizer
      The 50th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Washington DC, USA(一般演題)
    • Year and Date
      2011-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Occupational health survey on factory handling Titanium dioxide.2011

    • Author(s)
      Gaku Ichihara, Takahiro Kobayashi, Seiji Omura, Yuji Fujitani, Weihua Li Xuncheng Ding, Qiangyi Wang, Ying Liu, Yusuke Hiraku, Sahoko Ichihara.
    • Organizer
      ナノ・バイオメディシンシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genomics and proteomics analysis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of metabolic syndrome2011

    • Author(s)
      Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro Kuzuya, Sahoko Ichihara.
    • Organizer
      第10回分子予防環境医学研究会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteomic analysis of hippocampal protein in rats exposed 1-bromopropane2011

    • Author(s)
      Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Kaviarasan Suburamanian, Sahabudeen Sheil Mohideen, Gaku Ichihara.
    • Organizer
      第10回分子予防環境医学研究会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia activation in rat brain2011

    • Author(s)
      Sahabudeen Sheik Mohideen, Sahoko Ichihara, Zhenlie Huang, Lingyi Zhang, Kaviarasan Suburamanian, Gaku Ichihara.
    • Organizer
      第10回分子予防環境医学研究会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Invo lvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone- depleting solvents.2010

    • Author(s)
      Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi.
    • Organizer
      The 6th International Forum on "Oxidative Stress and Aging"
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone-depleting solvents.2010

    • Author(s)
      Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi.
    • Organizer
      The 6th International Forum on "Oxidative Stress and Aging"
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロアレイ及びプロテオミクス解析によるメタボリック症候群の標的分子マーカーの探索2010

    • Author(s)
      常杰、市原佐保子、安藤知沙、葛谷憲太郎、及川伸二
    • Organizer
      日本ヒトプロテオーム機構 第8回大会・第6回日本臨床プロテオーム研究会 連合大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテオミクス技術を用いた1-ブロモプロパンによる中枢神経障害に関連するタンパク質の探索2010

    • Author(s)
      安藤知沙、市原佐保子、葛谷憲太郎、常杰、黄振烈、市原学、及川伸二
    • Organizer
      日本ヒトプロテオーム機構 第8回大会・第6回日本臨床プロテオーム研究会 連合大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-07-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane.2010

    • Author(s)
      Gaku Ichihara, Weihua Li, Eiji Shibata, Zhijun Zhou, Sahoko Ichihara, Hailan Wang, Qiangyi Wang, Jefe Li, Lingyi Zhang, Yoshihiro Takeuchi, Xuncheng Ding.
    • Organizer
      The XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dose-dependent neuro logic abnor malities in workers exposed to 1-bromo propane.2010

    • Author(s)
      Gaku Ichihara, Weihua Li, Eiji Shibata, Zhijun Zhou, Sahoko Ichihara, Hailan Wang, Qiangyi Wang, Jefe Li, Lingyi Zhang, Yoshihiro Takeuchi, Xuncheng Ding.
    • Organizer
      The XII International Congress of Toxicology
    • Place of Presentation
      Barcelona, Spain(一般演題)
    • Year and Date
      2010-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] ストレス応答性転写因子Nrf2の心肥大における役割の解明2010

    • Author(s)
      市原佐保子、山田芳司、劉芳、伊東健、山本雅之、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な健康影響-再解析による新しい知見-2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] nrf2ノックアウトマウスは1-ブロモプロパン曝露に対し感受性が高い2010

    • Author(s)
      劉芳、市原佐保子、Sahabudeen Sheik Mohideen、伊東健、山本雅之、William M.Valentine、鬼頭純三、市原学
    • Organizer
      第80回日本衛生学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける1-ブロモプロパンの量依存的な神経、血管、生化学指標への影響-再解析による新しい知見-2010

    • Author(s)
      張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写因子nrf2による生体防御反応と酸化ストレスの1-ブロモプロパン毒性における役割2010

    • Author(s)
      劉芳、市原佐保子、シェイクモヒディーンザハブデーン、伊東健、山本雅之、ウィリアム エム ヴェレンタイン、鬼頭純三、市原学
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 建設作業者の職種と胸膜肥厚斑発生部位に関する検討2010

    • Author(s)
      柴田英治、Mo'men Hafez、市原学、市原佐保子、上島通弘、酒井潔
    • Organizer
      第83回日本産業衛生学会
    • Place of Presentation
      福井
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nrf-2 null mice are more susceptible to 1-bromopropoane-induced hepatotoxicity2010

    • Author(s)
      Liu F, Ichihara S, Mohideen SS, Itoh K, Yamamoto M, Valentine WM, Ichihara G.
    • Organizer
      第49回米国毒性学会
    • Place of Presentation
      Salt lake city
    • Year and Date
      2010-03-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nrf-2 null mice are more susceptible to 1-bromo propoane-induced hepatotoxicity.2010

    • Author(s)
      Fen Liu, Sahoko Ichihara, S Sheik Mohideen, Ken Itoh, Masayuki Yamamoto, William M Valentine, Gaku Ichihara.
    • Organizer
      The 49th Annual Meeting of the Society of Toxico logy
    • Place of Presentation
      Salt lake city, USA(一般演題)
    • Year and Date
      2010-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] N-acetyl-L-cysteine preven ts the toxic effects of hyperphosphatemia and hypozincemia on the testicular function in WKY, but not in SHR/NDmcr-cp, a model of metabolic syndrome2010

    • Author(s)
      Yuka Suzuki, Sahoko Ichihara, Ai Kato, Tonomori Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
    • Organizer
      The 49th Annual Meeting of the Society of Toxico logy
    • Place of Presentation
      Salt lake city, USA(一般演題)
    • Year and Date
      2010-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] N-acetyl-L-cysteine prevents the toxic effects of hyperphosphatemia and hypozincemia on the testicular function in WKY, but not in SHR/NDmcr-cp, a model of metabolic syndrome2010

    • Author(s)
      Suzuki Y, Ichihara S, Kato A, Yamaguchi T, Yamada Y, Ichihara G.
    • Organizer
      第49回米国毒性学会
    • Place of Presentation
      Salt lake city
    • Year and Date
      2010-03-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Nrf2 null mice are more susceptible to 1-bromopropane-induced hepatotoxicity2010

    • Author(s)
      劉芳, 市原佐保子, バレンタインウィリアム, 伊東健, 山本雅之, シェイク モヒディーンザハブデーン, 鬼頭純三, 市原学
    • Organizer
      第9回分子予防環境医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレス応答型転写因子Nrf2の血管新生における役割の解明2010

    • Author(s)
      市原佐保子, 劉芳, 山田芳司, 室原豊明, 伊東健, 山本雅之, 市原学
    • Organizer
      第9回分子予防環境医学研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide.2009

    • Author(s)
      Gaku Ichihara, Weihua Li, Yuji Fujitani, Sahoko Ichihara, Xuncheng Ding, Ying Liu, Qiangyi Wang, Uka Sai, Natsumi Hata, Takahiro Kobayashi.
    • Organizer
      The 4th International Conference on Nanotechnology Hel sinki
    • Place of Presentation
      Finland(一般演題)
    • Year and Date
      2009-08-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide2009

    • Author(s)
      Ichihara G, Li W, Fujitani Y, Ichihara S, Ding X, Liu Y, Wang Q, Sai U, Hata N, Kobayashi T.
    • Organizer
      The 4th International Conference on Nanotechnology
    • Place of Presentation
      フィンランド
    • Year and Date
      2009-08-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic risk for metabolic syndrome2009

    • Author(s)
      加藤公彦, 小栗光俊, 吉田哲郎, 藤巻哲夫, 河宮俊樹, 矢島和裕, 日比野剛, 横井清, 渡辺佐知郎, 市原佐保子, 山田芳司
    • Organizer
      第133回日本循環器学会東海地方会
    • Place of Presentation
      津
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン中枢神経影響のDNAマイクロアレイ解析と中枢神経毒性バイオマーカーの探索2009

    • Author(s)
      シェイクモヒディーンサハブディーン, 黄芬, 市原佐保子, 北河恵美子, 岩橋均, 劉芳, 市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパン感受性の分子的基盤2009

    • Author(s)
      劉芳, 市原佐保子, シェイクモヒディーンサハブディーン, 崔雨佳, 市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1-ブロモプロパンの神経毒性と血液毒性のヒト量-反応関係に関する研究2009

    • Author(s)
      李衛華, 柴田英治, ツアオツジュン, 市原佐保子, 王海蘭, 王強毅, 李浩斐, 竹内康浩, 丁訓誠, 市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレス応答に関与する転写因子Nrf2の血管新生における役割の解明2009

    • Author(s)
      市原佐保子, 山本雅之, 伊東健, 市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響2009

    • Author(s)
      劉穎, 李衛華, 陳波, 林靖彦, 市原佐保子, 丁訓誠, 市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスRAW264.7マクロファージとヒトA549肺細胞を用いた多層カーボンナノチューブが誘導する酸化ストレスの評価2009

    • Author(s)
      陳波, 李衛華, 劉穎, 林靖彦, 宋偉民, 市原佐保子, 丁訓誠, 市原学
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響.2009

    • Author(s)
      李衛華, 陳波, 劉穎, 林靖彦, 宋偉民, 市原佐保子, 丁訓誠, 市原学
    • Organizer
      第79回日本衛生学会
    • Place of Presentation
      東京、日本
    • Year and Date
      2009-03-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスRAW264.7マクロファージとヒトA549肺細胞に対する多層カーボンナノチューブにより誘導される酸化ストレスのIn vivo評価.2009

    • Author(s)
      陳波, 李衛華, 劉穎, 林靖彦, 宋偉民, 市原佐保子, 丁訓誠, 市原学
    • Organizer
      第79回日本衛生学会
    • Place of Presentation
      東京、日本
    • Year and Date
      2009-03-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ablation of Nrf2 resulted in enhancement of ischemia-induced angiogenesis.2009

    • Author(s)
      市原佐保子, 山田芳司, 劉芳, 山本雅之, 市原学
    • Organizer
      第79回日本衛生学会
    • Place of Presentation
      東京、日本
    • Year and Date
      2009-03-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Occupational health survey on workers handling titanium dioxide2009

    • Author(s)
      Sahoko Ichihara, Takahiro K obayashi, Weihua Li, Xuncheng Ding, Yuji Fujitani, Gaku Ichihara.
    • Organizer
      The 29th International Congress of Occupational Health
    • Place of Presentation
      Cape town. South Africa
    • Year and Date
      2009-03-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Occupational health survey on workers handling titanium dioxide.2009

    • Author(s)
      Sahoko Ichihara, Takahiro Kobayashi, Weihua Li, Xuncheng Ding, Yuji Fujitani, Gaku Ichihara.
    • Organizer
      The 29th International Congress of Occupa tional Health
    • Place of Presentation
      Cape town, South Africa(一般演題)
    • Year and Date
      2009-03-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Dose-dependent neurological and hema tological effects of 1-bromopropane exposure on workers.2009

    • Author(s)
      Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
    • Organizer
      The 29th International Congress of Occupa tional Health
    • Place of Presentation
      Cape town, South Africa(一般演題)
    • Year and Date
      2009-03-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Exposure assess ment and health exa mination on workers handling titanium dioxide.2009

    • Author(s)
      Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
    • Organizer
      The 48th Annu al Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA(一般演題)
    • Year and Date
      2009-03-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Inhibition of ischemia-induced angiogenesis by benzo [a] pyrene in a manner dependent on the aryl hydrocarbon receptor.2009

    • Author(s)
      Sahoko Ichihara, Yoshiji Yamada, Gaku Ichihara, Tamie Nakajima, Frank J Gonzalez, Toyoaki Murohara.
    • Organizer
      The 48th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA(一般演題)
    • Year and Date
      2009-03-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Exposure Assessment and Health Examination on Workers Handling Titanium Dioxide.2009

    • Author(s)
      Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
    • Organizer
      The 48th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスを用いた1-ブロモプロパン曝露感受性の分子的基盤に関する研究2009

    • Author(s)
      劉芳, 市原佐保子, シェイク モヒディーン ザハブデーン, 崔雨佳, 市原学
    • Organizer
      第8回分子予防環境医学研究会
    • Place of Presentation
      東京、日本
    • Year and Date
      2009-01-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ablation of Nrf2 resulted in enhancement of ischemia-induced angiogenesis.2008

    • Author(s)
      Sahoko Ichihara, Gaku Ichihara, Fang Liu, Toyoaki Murohara, Yoshiji Yamada.
    • Organizer
      The 81th Scientific Sessions of American Heart Association
    • Place of Presentation
      New Orleans, USA(一般演題)
    • Year and Date
      2008-11-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Occupa tional Health Survey on workers handling titanium dioxide.2008

    • Author(s)
      Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Qiangyi Wang, Uka Cui, Natsumi Hata, Sahoko Ichihara.
    • Organizer
      The 45th Congress of the European Societies of Toxicology
    • Place of Presentation
      Greece(一般演題)
    • Year and Date
      2008-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Research strategy for cardiovascular effects of manu factured nanomaterials.2008

    • Author(s)
      Sahoko Ichihara.
    • Organizer
      China-Japan Collaboration Workshop
    • Place of Presentation
      Shanghai, China ワークショップ
    • Year and Date
      2008-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] ナノ酸化チタン取扱工場労働者の健康調査2008

    • Author(s)
      崔雨佳, 市原佐保子, 李衛華, 劉穎, 王強毅, 丁訓誠, 小林隆弘, 藤谷雄二, 畑菜摘, 久永直見, 柴田英治, 酒井潔, 市原学
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌、日本
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノ酸化チタン取扱職場における曝露評価2008

    • Author(s)
      畑菜摘, 小林隆弘, 藤谷雄二, 李衛華, 市原佐保子, 劉穎, 王強毅, 丁訓誠, 崔雨佳, 久永直見, 柴田英治, 酒井潔, 市原学
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌、日本
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露労働者の量依存的な神経系、血管系影響2008

    • Author(s)
      李衛華, 柴田英治, 王強毅, 市原佐保子, 丁訓誠, 竹内康浩, 市原学
    • Organizer
      第81回日本産業衛生学会
    • Place of Presentation
      札幌、日本
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスはラットよりも1-ブロモプロパン曝露に対して感受性が高い-マウス系統間比較研究-2008

    • Author(s)
      劉芳, 崔雨佳, 市原佐保子, シェイク モヒディーン サハブディーン, 市原学
    • Organizer
      第78回日本衛生学会
    • Place of Presentation
      札幌、日本
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Peroxiredoxin 2 is a promising novel marker mediating the early phase of the left ventricular dysfunction in cardiomyopathy

    • Author(s)
      Kentaro Kuzuya, Sahoko Ichihara, Shinji Oikawa.
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      横浜(地震により開催中止)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genomic and proteomic analysis identifies the proteins associated with adipocyte lipolysis as key regulators for the pathogenesis of metabolic syndrome

    • Author(s)
      Jie Chang, Sahoko Ichihara, Shinji Oikawa.
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      横浜(地震により開催中止)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分散化多層カーボンナノチューブのラット脳への影響

    • Author(s)
      市原学、田中昭代、平田美由紀、市原佐保子、王強毅、伊東秀記
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京(地震により誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノ酸化チタンの心肺機能への影響に関する調査研究

    • Author(s)
      市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、丁訓誠、市原学
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京(地震により誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genomic and proteomic analysis identifies the proteins associated with adipocyte lipolysis as key regulators for the pathogenesis of metabolic syndrome

    • Author(s)
      Jie Chang, Sahoko Ichihara, Shinji Oikawa.
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京(地震により誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1-ブロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響

    • Author(s)
      Sahabudeen Sheik Mohideen, 市原佐保子、黄振烈、張霊逸、Kaviarasan Suburamanian, 市原学
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京(地震により誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 1-ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析

    • Author(s)
      黄振烈、市原佐保子、及川伸二、常杰、張霊逸、Kaviarasan Suburamanian, 市原学
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京(地震により誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Presentation] チェルノブイリ被災地域における罹患率調査(第1報)

    • Author(s)
      木村真三、七澤潔、竹内高明、三浦善憲、市原佐保子、市原学、サフー・サラタ、遠藤暁、大瀧慈、藤田博美
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京(地震により誌上開催)
    • Related Report
      2010 Annual Research Report
  • [Book] Stroke.2010

    • Author(s)
      Yoshiji Yamada, Sahoko Ichihara, Tamotsu Nishida.
    • Publisher
      New York : Oxford University Press.
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi