Physiological status depending on particle size in workers at the nano-handling factor

• Project/Area Number: 20406015
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Mie University
• Principal Investigator: ICHIHARA Sahoko Mie University, 大学院・地域イノベーション学研究科, 准教授 (20378326)
• Co-Investigator(Kenkyū-buntansha): HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510) ; ICHIHARA Gaku 名古屋大学, 大学院・医学系研究科, 准教授 (90252238) ; KOBAYASHI Takahiro 東京工業大学, 統合研究院, 特任教授 (50124342) ; OMURA Seiichi 東京工業大学, 統合研究院, ソリューション研究員 (80462480)
• Co-Investigator(Renkei-kenkyūsha): HISANAGA Naomi 愛知教育大学, 保健環境センター, 教授 (90111856) ; SHIBATA Eiji 愛知医科大学, 大学院・医学系研究科, 教授 (90206128)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: ナノ粒子 / 循環器疾患 / 心拍数 / リスク評価 / ナノ素材 / 心肺機能 / 粒子数 / 安全性 / ナノマテリアル / 酸化チタン / 酸化ストレス / 炎症 / 線維化

Research Abstract

The present study investigated possible respiratory and cardiovascular effects of titanium dioxide on the workers in Shanghai. The present study generated hypotheses that aggregation of particles might reduce nano-scaled particles by an absorption mechanism and that exposure to particle might increase the heart rate in workers handling titanium dioxide.

Research Products

• [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. (2011)
  • Author(s): Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M.
  • Journal Title: Eur J Hum Genet 19(3) Pages: 262-269
  • Peer Reviewed
• [Journal Article] Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. (2011)
  • Author(s): Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M.
  • Journal Title: Eur J Hum Genet Volume: 19 Pages: 262-269
  • Peer Reviewed
• [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. (2011)
  • Author(s): Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han BG, Ahn Y, Lee M, Shin DJ, Lee JH, Jang Y.
  • Journal Title: Atherosclerosis Volume: 215 Pages: 145-152
  • Peer Reviewed
• [Journal Article] Dose- dependent neurologic abnormalities in workers exposed to 1-bromopropane. (2010)
  • Author(s): Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
  • Journal Title: J Occup Environ Med 52(8) Pages: 769-777
  • Peer Reviewed
• [Journal Article] Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response. (2010)
  • Author(s): Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
  • Journal Title: Arterioscler Thromb Vasc Biol 30(8) Pages: 1553-1561
  • Peer Reviewed
• [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane induced hepatotoxicity (2010)
  • Author(s): Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Sai U, Kitoh J, Ichihara G.
  • Journal Title: Toxicol Sci 115(2) Pages: 596-606
  • Peer Reviewed
• [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters. (2010)
  • Author(s): Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
  • Journal Title: Circ J 74(1) Pages: 163-170
  • Peer Reviewed
• [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters. (2010)
  • Author(s): Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
  • Journal Title: Circulation Journal Volume: 74 Pages: 163-170
  • Peer Reviewed
• [Journal Article] Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity (2010)
  • Author(s): Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Sai U, Kitoh J, Ichihara G.
  • Journal Title: Toxicological Science Volume: 115 Pages: 596-606
  • Peer Reviewed
• [Journal Article] Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response. (2010)
  • Author(s): Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology Volume: 30 Pages: 1553-1561
  • Peer Reviewed
• [Journal Article] Dose-Dependent Neurologic Abnormalities in Workers Exposed to 1-Bromopropane. (2010)
  • Author(s): Li W, Shibata E, Zhou Z, Ichihara S, Wang H, Wang Q, Li J, Zhang L, Wakai K, Takeuchi Y, Ding X, Ichihara G.
  • Journal Title: Journal of Occupational and Environmental Medicine Volume: 52 Pages: 769-777
  • Peer Reviewed
• [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains. (2009)
  • Author(s): Liu F, Ichiharhar S, Mohideen SS, Sai U, Kitoh J, Ichihara G.
  • Journal Title: Toxicol Sci 112(1) Pages: 100-110
  • Peer Reviewed
• [Journal Article] Changes in neuro transmitter receptor expression levels in rat brain after 4-week exposure to 1- bromopropane. (2009)
  • Author(s): Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G.
  • Journal Title: Neurotoxicology 30(6) Pages: 1078-1083
  • Peer Reviewed
• [Journal Article] Inhibition of ischemia-induced angiogene sis by benzo [a] pyrene in a manner depen dent on the aryl hydrocarbon receptor. (2009)
  • Author(s): Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
  • Journal Title: Biochem Biophys Res Commun 381(1) Pages: 44-49
  • Peer Reviewed
• [Journal Article] Association of polymorphism of ABCB1 with obesity in Japanese individuals. (2009)
  • Author(s): Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Kojima T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y.
  • Journal Title: Genomics 91(6) Pages: 512-516
  • Peer Reviewed
• [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor (2009)
  • Author(s): Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
  • Journal Title: Biochemical and Biophysical Research Communication 381 Pages: 44-49
  • Peer Reviewed
• [Journal Article] Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane (2009)
  • Author(s): Mohideen SS, Ichihara S, Banu S, Liu F, Kitoh J, Ichihara G.
  • Journal Title: Neurotoxicology 10 Pages: 1078-1083
  • Peer Reviewed
• [Journal Article] Comparative study on susceptibility to 1-bromopropane in three mice strains (2009)
  • Author(s): Liu F, Ichihara S, Mohideen SS, Sai U, Kitoh J, Ichihara G.
  • Journal Title: Toxicological Science 112 Pages: 100-110
  • Peer Reviewed
• [Journal Article] Beneficial effects of growth hormone-related peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters (2009)
  • Author(s): Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M.
  • Journal Title: Circulation Journal 74 Pages: 163-170
  • Peer Reviewed
• [Journal Article] Inhibition of ischemia-induced angiogenesis by benzo [a] pyrene in a manner dependent on the aryl hydrocarbon receptor. (2009)
  • Author(s): Ichihara S, Yamada Y, Gonzalez FJ, Nakajima T, Murohara T, Ichihara G.
  • Journal Title: Biochem Biophys Res Commun (in press)
  • Peer Reviewed
• [Journal Article] Proinflammatory gene polymorphisms and ischemic stroke. (2008)
  • Author(s): Yamada Y, Ichihara S, Nishida T.
  • Journal Title: Curr Pharm Des 14 Pages: 3590-3600
  • Peer Reviewed
• [Presentation] The occu pational health survey on workers and nanoparticle numbers in the factory hand ling nano-titanium dioxide. (2011)
  • Author(s): Sahoko Ichihara, Weihua Li, Takahiro Kobayashi, Seiichi Omura, Yusuke Hiraku, Xuncheng Ding, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxico logy
  • Place of Presentation: Washington DC, USA(一般演題)
  • Year and Date: 2011-03-07
• [Presentation] Genomics and proteomics analy sis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of meta bolic syndrome. (2011)
  • Author(s): Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro, Kuzuya, Gaku Ichihara, Sahoko Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA(一般演題)
  • Year and Date: 2011-03-07
• [Presentation] Genomics and Proteomics Analysis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of metabolic syndrome. (2011)
  • Author(s): Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro, Kuzuya, Gaku Ichihara, Sahoko Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-07
• [Presentation] Hyperphosphatemia and Hypozincemia Affect Peripheral Nervous System in SHR/NDmcr-cp, a Model of Metabolic Syndrome. (2011)
  • Author(s): Yuka Suzuki, Sahoko Ichihara, Ai Kato, Takahiro Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-07
• [Presentation] The occupational health survey on workers and nanoparticle numbers in the factory handling nano-titanium dioxide. (2011)
  • Author(s): Sahoko Ichihara, Weihua Li, Takahiro Kobayashi, Seiichi Omura, Yusuke Hiraku, Xuncheng Ding, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-07
• [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia in rat brain. (2011)
  • Author(s): Sahabudeen Sheik Mohideen, Sahoko Ichihara, Zhen Huang, Ling Zhang, Kaviarasan Subramanian, Junzo Kitoh, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-07
• [Presentation] Exposure to 1-bromopropane Dedegenerates noradrenergic axons in the rat brain. (2011)
  • Author(s): Gaku Ichihara, Sahabudeen Sheik Mohideen, Sahoko Ichihara, Shoji Nakamura.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-07
• [Presentation] Hyperphosphat emia and hypozincemia affect peripheral nervous system in SHR/NDmcr-cp, a model of meta bolic syndrome. (2011)
  • Author(s): Yuka Suzuki, Sahoko Ichihara, Ai Kato, Takahiro Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
  • Organizer: The 50th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Washington DC, USA(一般演題)
  • Year and Date: 2011-03-06
• [Presentation] Occupational health survey on factory handling Titanium dioxide. (2011)
  • Author(s): Gaku Ichihara, Takahiro Kobayashi, Seiji Omura, Yuji Fujitani, Weihua Li Xuncheng Ding, Qiangyi Wang, Ying Liu, Yusuke Hiraku, Sahoko Ichihara.
  • Organizer: ナノ・バイオメディシンシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-02-21
• [Presentation] Genomics and proteomics analysis identified the proteins associated with adipocyte lipolysis as a key regulator for the pathogenesis or progression of metabolic syndrome (2011)
  • Author(s): Jie Chang, Shinji Oikawa, Chisa Ando, Kentaro Kuzuya, Sahoko Ichihara.
  • Organizer: 第10回分子予防環境医学研究会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-01-21
• [Presentation] Proteomic analysis of hippocampal protein in rats exposed 1-bromopropane (2011)
  • Author(s): Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Kaviarasan Suburamanian, Sahabudeen Sheil Mohideen, Gaku Ichihara.
  • Organizer: 第10回分子予防環境医学研究会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-01-21
• [Presentation] Effects of 1-bromopropane exposure on myelination and astroglia activation in rat brain (2011)
  • Author(s): Sahabudeen Sheik Mohideen, Sahoko Ichihara, Zhenlie Huang, Lingyi Zhang, Kaviarasan Suburamanian, Gaku Ichihara.
  • Organizer: 第10回分子予防環境医学研究会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-01-21
• [Presentation] Invo lvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone- depleting solvents. (2010)
  • Author(s): Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi.
  • Organizer: The 6th International Forum on "Oxidative Stress and Aging"
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2010-09-06
• [Presentation] Involvement of oxidative stress in toxicity of 1-bromopropane, an alternative to ozone-depleting solvents. (2010)
  • Author(s): Gaku Ichihara, Fang Liu, Junzoh Kitoh, Sahoko Ichihara, Yasuhiro Takeuchi.
  • Organizer: The 6th International Forum on "Oxidative Stress and Aging"
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2010-09-06
• [Presentation] マイクロアレイ及びプロテオミクス解析によるメタボリック症候群の標的分子マーカーの探索 (2010)
  • Author(s): 常杰、市原佐保子、安藤知沙、葛谷憲太郎、及川伸二
  • Organizer: 日本ヒトプロテオーム機構 第8回大会・第6回日本臨床プロテオーム研究会 連合大会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-26
• [Presentation] プロテオミクス技術を用いた1-ブロモプロパンによる中枢神経障害に関連するタンパク質の探索 (2010)
  • Author(s): 安藤知沙、市原佐保子、葛谷憲太郎、常杰、黄振烈、市原学、及川伸二
  • Organizer: 日本ヒトプロテオーム機構 第8回大会・第6回日本臨床プロテオーム研究会 連合大会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-26
• [Presentation] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane. (2010)
  • Author(s): Gaku Ichihara, Weihua Li, Eiji Shibata, Zhijun Zhou, Sahoko Ichihara, Hailan Wang, Qiangyi Wang, Jefe Li, Lingyi Zhang, Yoshihiro Takeuchi, Xuncheng Ding.
  • Organizer: The XII International Congress of Toxicology
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-20
• [Presentation] Dose-dependent neuro logic abnor malities in workers exposed to 1-bromo propane. (2010)
  • Author(s): Gaku Ichihara, Weihua Li, Eiji Shibata, Zhijun Zhou, Sahoko Ichihara, Hailan Wang, Qiangyi Wang, Jefe Li, Lingyi Zhang, Yoshihiro Takeuchi, Xuncheng Ding.
  • Organizer: The XII International Congress of Toxicology
  • Place of Presentation: Barcelona, Spain(一般演題)
  • Year and Date: 2010-07-11
• [Presentation] ストレス応答性転写因子Nrf2の心肥大における役割の解明 (2010)
  • Author(s): 市原佐保子、山田芳司、劉芳、伊東健、山本雅之、市原学
  • Organizer: 第80回日本衛生学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-10
• [Presentation] ヒトにおける1-ブロモプロパンの量依存的な健康影響-再解析による新しい知見- (2010)
  • Author(s): 張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
  • Organizer: 第80回日本衛生学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-10
• [Presentation] nrf2ノックアウトマウスは1-ブロモプロパン曝露に対し感受性が高い (2010)
  • Author(s): 劉芳、市原佐保子、Sahabudeen Sheik Mohideen、伊東健、山本雅之、William M.Valentine、鬼頭純三、市原学
  • Organizer: 第80回日本衛生学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-10
• [Presentation] ヒトにおける1-ブロモプロパンの量依存的な神経、血管、生化学指標への影響-再解析による新しい知見- (2010)
  • Author(s): 張霊逸、李衛華、柴田英治、市原佐保子、王強毅、李潔斐、若井健志、竹内康浩、丁訓誠、市原学
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: 福井
  • Year and Date: 2010-05-10
• [Presentation] 転写因子nrf2による生体防御反応と酸化ストレスの1-ブロモプロパン毒性における役割 (2010)
  • Author(s): 劉芳、市原佐保子、シェイクモヒディーンザハブデーン、伊東健、山本雅之、ウィリアム エム ヴェレンタイン、鬼頭純三、市原学
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: 福井
  • Year and Date: 2010-05-10
• [Presentation] 建設作業者の職種と胸膜肥厚斑発生部位に関する検討 (2010)
  • Author(s): 柴田英治、Mo'men Hafez、市原学、市原佐保子、上島通弘、酒井潔
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: 福井
  • Year and Date: 2010-05-10
• [Presentation] Nrf-2 null mice are more susceptible to 1-bromopropoane-induced hepatotoxicity (2010)
  • Author(s): Liu F, Ichihara S, Mohideen SS, Itoh K, Yamamoto M, Valentine WM, Ichihara G.
  • Organizer: 第49回米国毒性学会
  • Place of Presentation: Salt lake city
  • Year and Date: 2010-03-09
• [Presentation] Nrf-2 null mice are more susceptible to 1-bromo propoane-induced hepatotoxicity. (2010)
  • Author(s): Fen Liu, Sahoko Ichihara, S Sheik Mohideen, Ken Itoh, Masayuki Yamamoto, William M Valentine, Gaku Ichihara.
  • Organizer: The 49th Annual Meeting of the Society of Toxico logy
  • Place of Presentation: Salt lake city, USA(一般演題)
  • Year and Date: 2010-03-08
• [Presentation] N-acetyl-L-cysteine preven ts the toxic effects of hyperphosphatemia and hypozincemia on the testicular function in WKY, but not in SHR/NDmcr-cp, a model of metabolic syndrome (2010)
  • Author(s): Yuka Suzuki, Sahoko Ichihara, Ai Kato, Tonomori Yamaguchi, Yoshiji Yamada, Gaku Ichihara.
  • Organizer: The 49th Annual Meeting of the Society of Toxico logy
  • Place of Presentation: Salt lake city, USA(一般演題)
  • Year and Date: 2010-03-08
• [Presentation] N-acetyl-L-cysteine prevents the toxic effects of hyperphosphatemia and hypozincemia on the testicular function in WKY, but not in SHR/NDmcr-cp, a model of metabolic syndrome (2010)
  • Author(s): Suzuki Y, Ichihara S, Kato A, Yamaguchi T, Yamada Y, Ichihara G.
  • Organizer: 第49回米国毒性学会
  • Place of Presentation: Salt lake city
  • Year and Date: 2010-03-08
• [Presentation] Nrf2 null mice are more susceptible to 1-bromopropane-induced hepatotoxicity (2010)
  • Author(s): 劉芳, 市原佐保子, バレンタインウィリアム, 伊東健, 山本雅之, シェイク モヒディーンザハブデーン, 鬼頭純三, 市原学
  • Organizer: 第9回分子予防環境医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-22
• [Presentation] ストレス応答型転写因子Nrf2の血管新生における役割の解明 (2010)
  • Author(s): 市原佐保子, 劉芳, 山田芳司, 室原豊明, 伊東健, 山本雅之, 市原学
  • Organizer: 第9回分子予防環境医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-22
• [Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Yuji Fujitani, Sahoko Ichihara, Xuncheng Ding, Ying Liu, Qiangyi Wang, Uka Sai, Natsumi Hata, Takahiro Kobayashi.
  • Organizer: The 4th International Conference on Nanotechnology Hel sinki
  • Place of Presentation: Finland(一般演題)
  • Year and Date: 2009-08-27
• [Presentation] Exposure assessment and evaluation of health status in workers handling titanium dioxide (2009)
  • Author(s): Ichihara G, Li W, Fujitani Y, Ichihara S, Ding X, Liu Y, Wang Q, Sai U, Hata N, Kobayashi T.
  • Organizer: The 4th International Conference on Nanotechnology
  • Place of Presentation: フィンランド
  • Year and Date: 2009-08-26
• [Presentation] Genetic risk for metabolic syndrome (2009)
  • Author(s): 加藤公彦, 小栗光俊, 吉田哲郎, 藤巻哲夫, 河宮俊樹, 矢島和裕, 日比野剛, 横井清, 渡辺佐知郎, 市原佐保子, 山田芳司
  • Organizer: 第133回日本循環器学会東海地方会
  • Place of Presentation: 津
  • Year and Date: 2009-06-13
• [Presentation] 1-ブロモプロパン中枢神経影響のDNAマイクロアレイ解析と中枢神経毒性バイオマーカーの探索 (2009)
  • Author(s): シェイクモヒディーンサハブディーン, 黄芬, 市原佐保子, 北河恵美子, 岩橋均, 劉芳, 市原学
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-21
• [Presentation] 1-ブロモプロパン感受性の分子的基盤 (2009)
  • Author(s): 劉芳, 市原佐保子, シェイクモヒディーンサハブディーン, 崔雨佳, 市原学
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-21
• [Presentation] 1-ブロモプロパンの神経毒性と血液毒性のヒト量-反応関係に関する研究 (2009)
  • Author(s): 李衛華, 柴田英治, ツアオツジュン, 市原佐保子, 王海蘭, 王強毅, 李浩斐, 竹内康浩, 丁訓誠, 市原学
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-21
• [Presentation] ストレス応答に関与する転写因子Nrf2の血管新生における役割の解明 (2009)
  • Author(s): 市原佐保子, 山本雅之, 伊東健, 市原学
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-20
• [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響 (2009)
  • Author(s): 劉穎, 李衛華, 陳波, 林靖彦, 市原佐保子, 丁訓誠, 市原学
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-20
• [Presentation] マウスRAW264.7マクロファージとヒトA549肺細胞を用いた多層カーボンナノチューブが誘導する酸化ストレスの評価 (2009)
  • Author(s): 陳波, 李衛華, 劉穎, 林靖彦, 宋偉民, 市原佐保子, 丁訓誠, 市原学
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-20
• [Presentation] 多層カーボンナノチューブ気管内投与の肺に対する影響. (2009)
  • Author(s): 李衛華, 陳波, 劉穎, 林靖彦, 宋偉民, 市原佐保子, 丁訓誠, 市原学
  • Organizer: 第79回日本衛生学会
  • Place of Presentation: 東京、日本
  • Year and Date: 2009-03-31
• [Presentation] マウスRAW264.7マクロファージとヒトA549肺細胞に対する多層カーボンナノチューブにより誘導される酸化ストレスのIn vivo評価. (2009)
  • Author(s): 陳波, 李衛華, 劉穎, 林靖彦, 宋偉民, 市原佐保子, 丁訓誠, 市原学
  • Organizer: 第79回日本衛生学会
  • Place of Presentation: 東京、日本
  • Year and Date: 2009-03-31
• [Presentation] Ablation of Nrf2 resulted in enhancement of ischemia-induced angiogenesis. (2009)
  • Author(s): 市原佐保子, 山田芳司, 劉芳, 山本雅之, 市原学
  • Organizer: 第79回日本衛生学会
  • Place of Presentation: 東京、日本
  • Year and Date: 2009-03-31
• [Presentation] Occupational health survey on workers handling titanium dioxide (2009)
  • Author(s): Sahoko Ichihara, Takahiro K obayashi, Weihua Li, Xuncheng Ding, Yuji Fujitani, Gaku Ichihara.
  • Organizer: The 29th International Congress of Occupational Health
  • Place of Presentation: Cape town. South Africa
  • Year and Date: 2009-03-24
• [Presentation] Occupational health survey on workers handling titanium dioxide. (2009)
  • Author(s): Sahoko Ichihara, Takahiro Kobayashi, Weihua Li, Xuncheng Ding, Yuji Fujitani, Gaku Ichihara.
  • Organizer: The 29th International Congress of Occupa tional Health
  • Place of Presentation: Cape town, South Africa(一般演題)
  • Year and Date: 2009-03-23
• [Presentation] Dose-dependent neurological and hema tological effects of 1-bromopropane exposure on workers. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
  • Organizer: The 29th International Congress of Occupa tional Health
  • Place of Presentation: Cape town, South Africa(一般演題)
  • Year and Date: 2009-03-23
• [Presentation] Exposure assess ment and health exa mination on workers handling titanium dioxide. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
  • Organizer: The 48th Annu al Meeting of the Society of Toxicology
  • Place of Presentation: Baltimore, USA(一般演題)
  • Year and Date: 2009-03-17
• [Presentation] Inhibition of ischemia-induced angiogenesis by benzo [a] pyrene in a manner dependent on the aryl hydrocarbon receptor. (2009)
  • Author(s): Sahoko Ichihara, Yoshiji Yamada, Gaku Ichihara, Tamie Nakajima, Frank J Gonzalez, Toyoaki Murohara.
  • Organizer: The 48th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Baltimore, USA(一般演題)
  • Year and Date: 2009-03-17
• [Presentation] Exposure Assessment and Health Examination on Workers Handling Titanium Dioxide. (2009)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Uka Sai, Natsumi Hata, Qiangyi Wang, Sahoko Ichihara.
  • Organizer: The 48th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2009-03-17
• [Presentation] マウスを用いた1-ブロモプロパン曝露感受性の分子的基盤に関する研究 (2009)
  • Author(s): 劉芳, 市原佐保子, シェイク モヒディーン ザハブデーン, 崔雨佳, 市原学
  • Organizer: 第8回分子予防環境医学研究会
  • Place of Presentation: 東京、日本
  • Year and Date: 2009-01-24
• [Presentation] Ablation of Nrf2 resulted in enhancement of ischemia-induced angiogenesis. (2008)
  • Author(s): Sahoko Ichihara, Gaku Ichihara, Fang Liu, Toyoaki Murohara, Yoshiji Yamada.
  • Organizer: The 81th Scientific Sessions of American Heart Association
  • Place of Presentation: New Orleans, USA(一般演題)
  • Year and Date: 2008-11-09
• [Presentation] Occupa tional Health Survey on workers handling titanium dioxide. (2008)
  • Author(s): Gaku Ichihara, Weihua Li, Takahiro Kobayashi, Xuncheng Ding, Yuji Fujitani, Ying Liu, Qiangyi Wang, Uka Cui, Natsumi Hata, Sahoko Ichihara.
  • Organizer: The 45th Congress of the European Societies of Toxicology
  • Place of Presentation: Greece(一般演題)
  • Year and Date: 2008-10-06
• [Presentation] Research strategy for cardiovascular effects of manu factured nanomaterials. (2008)
  • Author(s): Sahoko Ichihara.
  • Organizer: China-Japan Collaboration Workshop
  • Place of Presentation: Shanghai, China ワークショップ
  • Year and Date: 2008-07-31
• [Presentation] ナノ酸化チタン取扱工場労働者の健康調査 (2008)
  • Author(s): 崔雨佳, 市原佐保子, 李衛華, 劉穎, 王強毅, 丁訓誠, 小林隆弘, 藤谷雄二, 畑菜摘, 久永直見, 柴田英治, 酒井潔, 市原学
  • Organizer: 第81回日本産業衛生学会
  • Place of Presentation: 札幌、日本
  • Year and Date: 2008-06-26
• [Presentation] ナノ酸化チタン取扱職場における曝露評価 (2008)
  • Author(s): 畑菜摘, 小林隆弘, 藤谷雄二, 李衛華, 市原佐保子, 劉穎, 王強毅, 丁訓誠, 崔雨佳, 久永直見, 柴田英治, 酒井潔, 市原学
  • Organizer: 第81回日本産業衛生学会
  • Place of Presentation: 札幌、日本
  • Year and Date: 2008-06-26
• [Presentation] 1-ブロモプロパン曝露労働者の量依存的な神経系、血管系影響 (2008)
  • Author(s): 李衛華, 柴田英治, 王強毅, 市原佐保子, 丁訓誠, 竹内康浩, 市原学
  • Organizer: 第81回日本産業衛生学会
  • Place of Presentation: 札幌、日本
  • Year and Date: 2008-06-25
• [Presentation] マウスはラットよりも1-ブロモプロパン曝露に対して感受性が高い-マウス系統間比較研究- (2008)
  • Author(s): 劉芳, 崔雨佳, 市原佐保子, シェイク モヒディーン サハブディーン, 市原学
  • Organizer: 第78回日本衛生学会
  • Place of Presentation: 札幌、日本
  • Year and Date: 2008-06-25
• [Presentation] Peroxiredoxin 2 is a promising novel marker mediating the early phase of the left ventricular dysfunction in cardiomyopathy
  • Author(s): Kentaro Kuzuya, Sahoko Ichihara, Shinji Oikawa.
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜(地震により開催中止)
• [Presentation] Genomic and proteomic analysis identifies the proteins associated with adipocyte lipolysis as key regulators for the pathogenesis of metabolic syndrome
  • Author(s): Jie Chang, Sahoko Ichihara, Shinji Oikawa.
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: 横浜(地震により開催中止)
• [Presentation] 分散化多層カーボンナノチューブのラット脳への影響
  • Author(s): 市原学、田中昭代、平田美由紀、市原佐保子、王強毅、伊東秀記
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京(地震により誌上開催)
• [Presentation] ナノ酸化チタンの心肺機能への影響に関する調査研究
  • Author(s): 市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、丁訓誠、市原学
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京(地震により誌上開催)
• [Presentation] Genomic and proteomic analysis identifies the proteins associated with adipocyte lipolysis as key regulators for the pathogenesis of metabolic syndrome
  • Author(s): Jie Chang, Sahoko Ichihara, Shinji Oikawa.
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京(地震により誌上開催)
• [Presentation] 1-ブロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響
  • Author(s): Sahabudeen Sheik Mohideen, 市原佐保子、黄振烈、張霊逸、Kaviarasan Suburamanian, 市原学
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京(地震により誌上開催)
• [Presentation] 1-ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析
  • Author(s): 黄振烈、市原佐保子、及川伸二、常杰、張霊逸、Kaviarasan Suburamanian, 市原学
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京(地震により誌上開催)
• [Presentation] チェルノブイリ被災地域における罹患率調査(第1報)
  • Author(s): 木村真三、七澤潔、竹内高明、三浦善憲、市原佐保子、市原学、サフー・サラタ、遠藤暁、大瀧慈、藤田博美
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京(地震により誌上開催)
• [Book] Stroke. (2010)
  • Author(s): Yoshiji Yamada, Sahoko Ichihara, Tamotsu Nishida.
  • Publisher: New York : Oxford University Press.