Genetic epidemiology study for lifestyle-related disease by considering compartmentalization of environmental factors
| Project/Area Number |
20406019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Public health/Health science
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| Research Institution | 独立行政法人・国立国際医療研究センター(研究所) (2010)
Research Institute, International Medical Center of Japan (2008-2009) |
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Principal Investigator |
KATO Norihiro 独立行政法人・国立国際医療研究センター(研究所), 部長 (80293934)
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| Co-Investigator(Kenkyū-buntansha) |
YAMORI Yukio 武庫川大学付置研究所, 教授 (80025600)
MAKAYA Miyuki 国立国際医療研究センター研究所, 室長 (60415552)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAMURA Noriyuki 国立精神神経センター精神保健研究所, 室長 (60211869)
IKEDA Katsumi (80273499)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | メタボリックシンドローム / 糖尿病 / 内臓肥満 / 心血管病 / 地域保健 / スリランカ / 遺伝疫学 / 内蔵肥満 |
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| Research Abstract |
To establish the efficient preventive strategy for lifestyle-related diseases such as diabetes, in-depth understanding of the disease pathophysiology is essential. We therefore performed baseline(cross-sectional) survey of lifestyle and health statuses among the residents near Colombo(n=3012) and those in the estate(n=403). By comparing the results between 2 populations, we found that the Sri Lankans were likely to have prominent genetic susceptibility to diabetes and its related metabolic disorders despite the substantial influences of environmental factors on the disease.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Common variants at the GCK, GCKR, G6PC2-ABCB11, and MTNR1B loci are associated with fasting glucose in two Asian populations2010
Author(s)
Takeuchi F, Katsuya T, Charkrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N
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Journal Title
Diabetologia
Volume: 53(2)
Pages: 299-308
Related Report
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[Journal Article] Prevalence and risk factors for non-alcoholic fatty liver disease(NAFLD) among adults in an urban Sri Lankan population2009
Author(s)
Dassanayake AS, Kasthuriratne A, Rajindrajith S, Kalubowila U, Chakrawarthi S, De Silva AP, Makaya M, Mizoue T, Kato N, Wickremasinghe AR, de Silva HJ
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Journal Title
J Gastroenterol Hepatol
Volume: 24(7)
Pages: 1284-8
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