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Genetic epidemiology study for lifestyle-related disease by considering compartmentalization of environmental factors

Research Project

Project/Area Number 20406019
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research Institution独立行政法人・国立国際医療研究センター(研究所) (2010)
Research Institute, International Medical Center of Japan (2008-2009)

Principal Investigator

KATO Norihiro  独立行政法人・国立国際医療研究センター(研究所), 部長 (80293934)

Co-Investigator(Kenkyū-buntansha) YAMORI Yukio  武庫川大学付置研究所, 教授 (80025600)
MAKAYA Miyuki  国立国際医療研究センター研究所, 室長 (60415552)
Co-Investigator(Renkei-kenkyūsha) KAWAMURA Noriyuki  国立精神神経センター精神保健研究所, 室長 (60211869)
IKEDA Katsumi   (80273499)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsメタボリックシンドローム / 糖尿病 / 内臓肥満 / 心血管病 / 地域保健 / スリランカ / 遺伝疫学 / 内蔵肥満
Research Abstract

To establish the efficient preventive strategy for lifestyle-related diseases such as diabetes, in-depth understanding of the disease pathophysiology is essential. We therefore performed baseline(cross-sectional) survey of lifestyle and health statuses among the residents near Colombo(n=3012) and those in the estate(n=403). By comparing the results between 2 populations, we found that the Sri Lankans were likely to have prominent genetic susceptibility to diabetes and its related metabolic disorders despite the substantial influences of environmental factors on the disease.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Prevalence of acanthosis nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome2011

    • Author(s)
      Dassanayake AS, Kasturiratne A, Niriella MA, Kalubovila U, Rajindrajith S, De Silva AP, Kato N, Wickremasinghe R and de Silva J
    • Journal Title

      BMC Research Notes

      Volume: 4(1) Pages: 25-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants2011

    • Author(s)
      Takeuchi F, Kobayashi S, Ogihara T, Fujioka A, Kato N
    • Journal Title

      Genome Res

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prevalence of acanthosis nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome2011

    • Author(s)
      Dassanayake AS, et al
    • Journal Title

      BMC Research Notes

      Volume: 4 Pages: 25-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variants at the GCK, GCKR, G6PC2-ABCB11, and MTNR1B loci are associated with fasting glucose in two Asian populations2010

    • Author(s)
      Takeuchi F, Katsuya T, Charkrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N
    • Journal Title

      Diabetologia

      Volume: 53(2) Pages: 299-308

    • Related Report
      2010 Final Research Report
  • [Journal Article] Blood pressure and hypertension are associated with seven loci showing male-specific interaction with age among the Japanese2010

    • Author(s)
      Takeuchi F, et al
    • Journal Title

      Circulation

      Volume: 121 Pages: 2302-2309

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common vahants at the GCK, GCKR, G6PC2-ABCB11, and MTNR1B loci are associated with fasting glucose in two Asian populations2010

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Diabetologia 53

      Pages: 299-308

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and risk factors for non-alcoholic fatty liver disease(NAFLD) among adults in an urban Sri Lankan population2009

    • Author(s)
      Dassanayake AS, Kasthuriratne A, Rajindrajith S, Kalubowila U, Chakrawarthi S, De Silva AP, Makaya M, Mizoue T, Kato N, Wickremasinghe AR, de Silva HJ
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 24(7) Pages: 1284-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prevalence and risk factors for non-alcoholic fatty liver disease (NAFLD) among adults in an urban Sri Lankan population2009

    • Author(s)
      AS Dassanayake, et al.
    • Journal Title

      J Gastroenterol Hepatol 24(印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of Cardiovascular Disease Risk Factors among Young and Middle-age Men in Urban Mwanza, Tanzania

    • Author(s)
      Njelekela M, Muhihi A, Mpembeni R, Masesa Z, Kitamori K, Mori-Yamori M, Kato N, Mtabaji J, Yamori Y
    • Journal Title

      J Public Health

      Volume: (Accepted)

    • Related Report
      2010 Final Research Report
  • [Presentation] Risk of myocardial infarction and stroke among Asians2010

    • Author(s)
      Kato N
    • Organizer
      10th South East Asia Regional Scientific Meeting of the International Epidemiological Association
    • Place of Presentation
      Colombo, Sri Lanka
    • Related Report
      2010 Final Research Report
  • [Presentation] Testing heterogeneity of quantitative trait variance among genotype classes guides fine mapping of association signals2010

    • Author(s)
      Takeuchi F, et al
    • Organizer
      Annual meeting of the American Society of Human Genetics
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] For the NIBIO GWA Study and Ragama Health Study. Confirmation of eight loci associated with measures of obesity in two Asian populations with substantial ethnic heterogeneity2009

    • Author(s)
      Takeuchi F, Kato N, et al.
    • Organizer
      27th annual scientific meeting of the Obesity Society
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] For the NIBIO GWA Study. Ethnic diversity in fine mapping of the susceptibility loci G6PC2-ABCB11 for fasting glucose and CDKAL1 for type 2 diabetes2009

    • Author(s)
      Takeuchi F, Kato N, et al.
    • Organizer
      59th annual meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Confirmation of eight loci associated with measures of obesity in two Asian populations with substantial ethnic heterogeneity2009

    • Author(s)
      Takeuchi F, et al.
    • Organizer
      Annual scientific meeting of the Obesity Society
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Type 2 Diabetes is Associated with Decreased Plasma Adiponectin Levels Independently of Insulin Resistance in South Asians2008

    • Author(s)
      加藤, 規弘
    • Organizer
      日本高血圧学会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Type 2 Diabetes is associated with decreased plasma adiponectin levels independently of insulin resistance in South Asians2008

    • Author(s)
      Zhang Y, Kato N, et al.
    • Organizer
      第31回日本高血圧学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Book] 高血圧のゲノムワイド関連解析, Annual Review循環器2011

    • Author(s)
      加藤規弘
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] ゲノムと循環器病,カラー版循環器病学-基礎と臨床-2010

    • Author(s)
      加藤規弘
    • Publisher
      西村書店
    • Related Report
      2010 Final Research Report
  • [Book] 高血圧研究における遺伝子解析の現状と展望,高血圧(上)第4版-基礎編-日本臨床2009年増刊2009

    • Author(s)
      加藤規弘
    • Related Report
      2010 Final Research Report
  • [Book] メタボリックシンドロームの理解,「メタボリックシンドローム概論:生活習慣病ナーシング1」2008

    • Author(s)
      加藤規弘
    • Publisher
      メヂカルフレンド社
    • Related Report
      2010 Final Research Report
  • [Book] 高血圧の遺伝子座が位置する染色体領域, Medical Practice

    • Author(s)
      加藤規弘
    • Publisher
      文光堂
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ研究室ホームページ

    • URL

      http://www.imcj-gdt.jp/index-j.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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