| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
The CNR/Protocadherin-alpha genes (Pcdha), which are expressed in the vertebrate brain, encode diverse membrane proteins whose functions are involved in axonal projection. In this study, to elucidate the physiological significance of CNR/Pcdha diversity, we deleted or duplicated the CNR/Pcdha gene cluster in mice. These mice were viable, and did not display any overt abnormalities. The expression level of all the CNR/Pcdha genes was unchanged in the all mutant mice. These results indicate that the Pcdha genes are comprehensively regulated as a cluster unit.
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