Functional analysis of GluD2 signal transduction
Project/Area Number |
20500292
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | Keio University |
Principal Investigator |
KOHDA Kazuhisa Keio University, 医学部, 講師 (40334388)
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Co-Investigator(Kenkyū-buntansha) |
EMI Kyoichi 慶應義塾大学, 医学部, 研究員(非常勤) (70468495)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | デルタ2グルタミン酸受容体 / 長期抑圧 / 小脳 / シナプス可塑性 / グルタミン酸受容体 |
Research Abstract |
We performed functional analysis of the δ2 glutamate receptor (δ2) through phenotype-rescue method. By transducing an N-terminal mutant of δ2 into δ2-null Purkinje cells, we demonstrated that the extracellular N-terminal region of δ2 was indispensable for parallel fiber (PF)-Purkinje cell (PC) synapse formation and/or maintenance, but not for long-term depression (LTD), a form of plasticity in PF-PC synapses. We also found that PTPMEG, a tyrosine phosphatase interacting with the C-terminal region of δ2, dephosphorylated type-2 glutamate receptors in the induction of LTD.
|
Report
(4 results)
Research Products
(18 results)
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[Journal Article] D-Serine regulates cerebellar LTD and motor coordination through the delta2 glutamate receptor.2011
Author(s)
Kakegawa W, Miyoshi Y, Hamase K, Matsuda S, Matsuda K, Kohda K, Emi K, Motohashi J, Konno R, Zaitsu K, Yuzaki M
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Journal Title
Nat Neurosci 14
Pages: 603-6011
Related Report
Peer Reviewed
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[Journal Article] D-Serine regulates cerebellar LTD and motor coordination through the delta2 glutamate receptor.2011
Author(s)
Kakegawa W, Miyoshi Y, Hamase, K, Matsuda S, Matsuda K, Kohda K, Emi K, Motohashi J, Konno R, Zaitsu K, Yuzaki M.
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Journal Title
Nature Neuroscience
Volume: (Epub ahead of print.)
Related Report
Peer Reviewed
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[Journal Article] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.2010
Author(s)
Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T
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Journal Title
Neuron
Volume: 65
Pages: 480-9
Related Report
Peer Reviewed
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[Journal Article] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.2010
Author(s)
Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression.2008
Author(s)
Nakagami, R., Kohda, K., Kakegawa, W., Kondo, T., Kato, N., Yuzaki, M.
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Journal Title
Keio J Med 57
Pages: 105-110
Related Report
Peer Reviewed
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[Journal Article] Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression.2008
Author(s)
Nakagami, R., Kohda, K., Kake gawa, W., Kondo, T., Kato, N., Yuzaki
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Journal Title
Keio Journal of Medicine 57
Pages: 105-110
Related Report
Peer Reviewed
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