Functional analyses of ion-channels and receptors in adult and developing mammalian sensory neurons.
| Project/Area Number |
20500294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Fujita Health University |
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Principal Investigator |
MIYACHI Ei-ichi Fujita Health University, 医学部, 教授 (90129685)
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| Co-Investigator(Renkei-kenkyūsha) |
OHKUMA Mahito 藤田保健衛生大学, 医学部, 講師 (50329710)
IMADA Hideki 藤田保健衛生大学, 医学部, 助教 (70387710)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 網膜 / 網膜発生 / 視細胞 / 網膜神経節細胞 / ヒスタミン / ドーパミン / HCNチャネル / h電流 / 神経節細胞 / アマクリン細胞 / H1受容体 / H2受容体 / H3受容体 / ヒスチジン脱炭酸酵素 |
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| Research Abstract |
Histamine and histamine H1 receptor exist in the gerbil retina, and that H2 and H3 receptors were expressed on developing gerbil ganglion cells.
In human rod photoreceptors, dopamine reduced h current (Ih) through a D2 receptor, and inhibited the gradual decay in the voltage response via a D2 receptor, indicating that dopamine slows the recovery phase of responses to light stimuli by inhibiting Ih in human rods.
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Report
(4 results)
Research Products
(41 results)
