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Functional analyses of ion-channels and receptors in adult and developing mammalian sensory neurons.

Research Project

Project/Area Number 20500294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionFujita Health University

Principal Investigator

MIYACHI Ei-ichi  Fujita Health University, 医学部, 教授 (90129685)

Co-Investigator(Renkei-kenkyūsha) OHKUMA Mahito  藤田保健衛生大学, 医学部, 講師 (50329710)
IMADA Hideki  藤田保健衛生大学, 医学部, 助教 (70387710)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords網膜 / 網膜発生 / 視細胞 / 網膜神経節細胞 / ヒスタミン / ドーパミン / HCNチャネル / h電流 / 神経節細胞 / アマクリン細胞 / H1受容体 / H2受容体 / H3受容体 / ヒスチジン脱炭酸酵素
Research Abstract

Histamine and histamine H1 receptor exist in the gerbil retina, and that H2 and H3 receptors were expressed on developing gerbil ganglion cells.
In human rod photoreceptors, dopamine reduced h current (Ih) through a D2 receptor, and inhibited the gradual decay in the voltage response via a D2 receptor, indicating that dopamine slows the recovery phase of responses to light stimuli by inhibiting Ih in human rods.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 4 results) Presentation (27 results)

  • [Journal Article] Dopamine modulates voltage response of human rod photoreceptors by inhibiting h current.2011

    • Author(s)
      Fusao Kawai, Masayuki Horiguchi, E.Miyachi
    • Journal Title

      Investigative Ophthalmology & Visual Science 10.1167/iovs.

      Pages: 10-6983

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine modulates voltage response of human rod photoreceptors by inhibiting h current.2011

    • Author(s)
      Fusao Kawai, Masayuki Horiguchi, E.Miyachi
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 10.1167/iovs.10-6983

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食品の香りの感覚情報処理機構における神経生理学的解析.(A neurophysiological study of mechanism underlying sensory infor- mation processing on the smell of food.)2009

    • Author(s)
      河合房夫,宮地栄一
    • Journal Title

      Aroma Research 10(2)

      Pages: 123-127

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食品の香りの感覚情報処理機構における神経生理学的解析2009

    • Author(s)
      河合房夫
    • Journal Title

      Aroma Research VOL.10

      Pages: 123-127

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The postnatal expression of histamine receptors in the gerbil retina2009

    • Author(s)
      Hideki Imada, 他4名
    • Journal Title

      Journal of Physiological Sciences VOL.59

      Pages: 139-139

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Acetylcholine affects the signal encoding in newt olfactory receptor cells2009

    • Author(s)
      Mahito Ohkuma, 他2名
    • Journal Title

      Journal of Physiological Sciences VOL.59

      Pages: 148-148

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Vestibulo-ocular responses in flat fish for the changes of acceleration2009

    • Author(s)
      Kaori Iwata, 他5名
    • Journal Title

      Journal of Physiological Sciences VOL.59

      Pages: 533-533

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effect of lycopene as antioxidant on hippocampus of Mongolian gerbilafter ischemia/reperfusion2009

    • Author(s)
      Kimikazu Fujita, 他6名
    • Journal Title

      Neuroscience Research VOL.65

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Dopamine reduces an h current in human rod photoreceptors via a D2 receptor2009

    • Author(s)
      Fusao Kawai, 他2名
    • Journal Title

      Neuroscience Research VOL.65

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Localization of histamine H2 receptor in the gerbil retina2009

    • Author(s)
      Mahito Ohkuma, 他2名
    • Journal Title

      Neuroscience Research VOL.65

    • Related Report
      2009 Annual Research Report
  • [Journal Article] APCは後シナプスへのPSD-95とAMPA受容体のクラスタリングを促進する2008

    • Author(s)
      下村敦司,大熊真人,向後晶子,野村隆士,宮地栄一,千田隆夫
    • Journal Title

      藤田学園医学会誌 32(1)

      Pages: 1-5

    • Related Report
      2010 Final Research Report
  • [Journal Article] Distribution and localization of histamine receptors in the developing gerbi1 retina.2008

    • Author(s)
      Hideki Imada
    • Journal Title

      Neurosci ence Research 61巻(Suppl. l)

      Pages: 101-101

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Histamine affects olfactory signals in the olfactory epithelium and bulb.2008

    • Author(s)
      Mahito Ohkuma
    • Journal Title

      Neuroscience Research 61巻(Suppl. l)

      Pages: 179-179

    • Related Report
      2008 Annual Research Report
  • [Journal Article] APCは後シナプスへのPSD-95とAMPA受容体のクラスタリングを促進する2008

    • Author(s)
      下村敦司
    • Journal Title

      藤田学園医学会誌 32巻(1)

      Pages: 1-5

    • Related Report
      2008 Annual Research Report
  • [Presentation] スナネズミ網膜の発達過程におけるヒスタミン作動性神経節細胞2011

    • Author(s)
      今田英己,酒井一由,大熊真人,加藤寿章,宮地栄一
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Histamine modulates membrane currents in the gerbil retinal ganglion cells. Neuroscience 20102010

    • Author(s)
      大熊真人, 今田英己, 宮地栄一
    • Organizer
      the 2010 annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Histamine modulates membrane currents in the gerbil retinal ganglion cells.2010

    • Author(s)
      Mahito Ohkuma
    • Organizer
      Neuroscience 2010 (The 2010 annual meeting of the Society for Neuroscience).
    • Place of Presentation
      San Diego, CA, U.S.A.
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ドーパミンはヒト杆体視細胞の膜電位応答を修飾する2010

    • Author(s)
      河合房夫,堀口正之,宮地栄一
    • Organizer
      第57回中部日本生理学会
    • Place of Presentation
      豊明
    • Year and Date
      2010-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] スナネズミ網膜神経節細胞におけるヒスタミンの影響2010

    • Author(s)
      大熊真人,今田英己,宮地栄一
    • Organizer
      第57回中部日本生理学会
    • Place of Presentation
      豊明
    • Year and Date
      2010-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] ドーパミンはヒト杆体視細胞の膜電位応答を修飾する2010

    • Author(s)
      河合房夫
    • Organizer
      57回中部日本生理学会
    • Place of Presentation
      豊明
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] スナネズミ網膜神経節細胞におけるヒスタミンの影響2010

    • Author(s)
      大熊真人
    • Organizer
      57回中部日本生理学会
    • Place of Presentation
      豊明
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] スナネズミ網膜におけるヒスタミンによる電位依存性チャネルの修飾2010

    • Author(s)
      大熊真人,今田英己,宮地栄一
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 脳虚血・再灌流負荷後の海馬におけるSODとGPx活性の変化に及ぼすリコピン摂取量の影響2010

    • Author(s)
      藤田公和,芳本信子,今田英己,松本岳,稲熊隆博,加藤寿章,永田豊,宮地栄一
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] スナネズミ網膜神経節細胞におけるヒスタミンの免疫組織化学とカルシウムイメージング解析2010

    • Author(s)
      今田英己,小久保正博,大熊真人,加藤寿章,宮地栄一
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] スナネズミ網膜神経節細胞におけるヒスタミンの免疫組織化学とカルシウムイメージング解析2010

    • Author(s)
      今田英己
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistochemical and physiological analyses of histamine and histamine receptors on ganglion cells in the developing gerbil retina. Neuroscience 20092009

    • Author(s)
      H.Imada, M.Ohkuma, M.Kokubo, T.Kato, E.Miyachi
    • Organizer
      the 2009 annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Immunohistochemical and physiological analyses of histamine and histamine receptors on ganglion cells in the developing gerbil retina2009

    • Author(s)
      Hideki Imada
    • Organizer
      2009 Annual Meeting of Society for Neuroscience
    • Place of Presentation
      マコーミックプレイス(シカゴ)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] ドーパミンはD2レセプターを介してヒト杆体視細胞のh電流を減少させる2009

    • Author(s)
      河合房夫,堀口正之,宮地栄一
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] スナネズミ網膜におけるヒスタミンH2受容体の局在2009

    • Author(s)
      今田英己,大熊真人,宮地栄一
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳虚血再灌流負荷後のスナネズミの海馬組織における抗酸化物質としてのリコピンの効果2009

    • Author(s)
      藤田公和,芳本信子,今田英己,松本岳,稲熊隆博,永田豊,宮地栄一
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Immunohistochemical and calcium-imaging analyses of histamine and histamine receptors in mammalian retinal neurons2009

    • Author(s)
      Hideki Imada
    • Organizer
      Neuroscience 2009(The 32^<nd> Annual Meeting of the Japan Neuroscience Society)
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vestibulo-ocular responses in flat fish for the changes of acceleration.2009

    • Author(s)
      Kaori Iwata, Masatika Takagi, Hideki Imada, Ei-ichi Miyachi, Shunji Nagaoka, Akira Takabayashi
    • Organizer
      International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] The postnatal expression of histamine receptors in the gerbil retina.2009

    • Author(s)
      Hideki Imada, Masahiro Kokubo, Mahito Ohkuma, Toshi-aki Kato, Ei-ichi Miyachi
    • Organizer
      International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Acetylcholine affects the signal encoding in newt olfactory receptor cells.2009

    • Author(s)
      Mahito Ohkuma, Fusao Kawai, Ei-ichi Miyachi
    • Organizer
      International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation by dopamine of an h current in human rod photoreceptors. Neuroscience 20082008

    • Author(s)
      F.Kawai, M.Horiguchi, E.-I.Miyachi
    • Organizer
      the 2008 annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation by dopamine of an h current in human rod photoreceptors.2008

    • Author(s)
      Ei-ichi Miyachi
    • Organizer
      Neuroscience 2008(Society for Neuroscience)
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Histamine receptors in the gerbil retina. Neuroscience 20082008

    • Author(s)
      H.Imada, M.Ohkuma, M.Kokubo, T.-A.Kato, E.Miyachi
    • Organizer
      the 2008 annual meeting of Society for Neuroscience
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Histamine receptors in the gerbi1 retina.2008

    • Author(s)
      Ei-ichi Miyachi
    • Organizer
      Neuroscience 2008(Society for Neuroscience)
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅覚情報処理におけるヒスタミンの影響2008

    • Author(s)
      大熊真人,三村英也,今田英己,内藤健晴,宮地栄一
    • Organizer
      Neuroscience 2008(第31回日本神経科学大会)
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] スナネズミ網膜の発達過程におけるヒスタミンレセプターの分布と局在2008

    • Author(s)
      今田英己,小久保正博,加藤寿章,大熊真人,宮地栄一
    • Organizer
      Neuroscience 2008(第31回日本神経科学大会)
    • Place of Presentation
      東京(ポスター発表)
    • Year and Date
      2008-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] スナネズミ網膜の発達過程におけるヒスタミンレセプターの分布と局在2008

    • Author(s)
      今田 英己
    • Organizer
      Neuroscience 2008(第31回日本神経科学大会)
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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