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Regulation mechanism of inhibitory synaptic plasticity

Research Project

Project/Area Number 20500296
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTokushima Bunri University

Principal Investigator

KURIU Toshihiko  Tokushima Bunri University, 香川薬学部, 助教 (10401374)

Co-Investigator(Renkei-kenkyūsha) KONISHI Shiro  徳島文理大学, 香川薬学部, 教授 (20014277)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords抑制性シナプス / シナプス可塑性 / シナプス形成 / 神経科学 / 可塑性 / 長期増強 / GABA / 抑制シナプス
Research Abstract

To visualize dynamics of both presynaptic and postsynaptic structures on inhibitory synapse, we used two distinct pre- and postsynaptic fluorescent probes. Venus-expressing presynaptic inhibitory varicosities markedly change their morphology and the postsynaptic clusters of mCherry-gephyrin dynamically move around inhibitory synaptic sites. These movements of inhibitory synaptic contact sites stabilized depending on the length of culture period. The motilities of preaynaptic varicosities and postsynaptic gephyrin clusters significantly decreased during the period of the maximum increases in their densities. They underwent characteristic long-lasting changes (fusion, fission, movement) in their shape during synaptogenesis. These results suggest that motilities of pre- and postsynaptic structure could play an important role in the inhibitory synapse formation, including rearrangements during synaptogenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Remarks (4 results)

  • [Journal Article] Regulation of dendritic spine morphology by an NMDA receptor-associated RhoGTPase activating protein, p250GAP.2008

    • Author(s)
      Nakazawa T., Kuriu T., Tezuka T., Umemori H., Okabe S., Yamamoto T.
    • Journal Title

      J.Neurochem. 105

      Pages: 1384-1393

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP2008

    • Author(s)
      Nakazawa T., Kuriu T., Tezuka T., et al.
    • Journal Title

      Journal of Neurochemistry 105 (4)

      Pages: 1384-1393

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Formation and dynamics of GABAergic inhibitory synaptic connections between hippocampal interneurons and pyramidal neurons.2010

    • Author(s)
      Kuriu T., Yanagawa Y., Konishi S.
    • Organizer
      2010 Neuroscience Meeting Planner. Society for Neuroscience, 2010.
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Formation and dynamics of GABAergic inhibitory synaptic connections between hippocampal interneurons and pyramidal neurons.2010

    • Author(s)
      栗生俊彦・柳川右千夫・小西史朗
    • Organizer
      2010 Neuroscience Meeting Planner.San Diego, CA : Society for Neuroscience, 2010.
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Doublecortin-like kinaseによる神経細胞の樹状突起形態・シナプス機能の統合的調節2010

    • Author(s)
      申義庚、栗生俊彦、岡部繁男
    • Organizer
      Neuro2010(第33回神経科学大会、第53回日本神経化学会大会、第20回日本神経回路学会大会、合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Simultaneous imaging of the motility of presynaptic varicosities and postsynaptic scaffoliding proteins at inhibitory synapses.2009

    • Author(s)
      栗生俊彦、柳川右千夫、小西史朗
    • Organizer
      第36回国際生理学会(IUPS2009)
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Simultaneous imaging of the motility of presynaptic varicosities and postsynaptic scaffolding proteins at inhibitory synapses2009

    • Author(s)
      栗生俊彦
    • Organizer
      第36回国際生理学会世界大会(IUPS 2009)
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] p250GAP, a brain-enriched RhoGAP, in involved in the NMDA-mediated signaling.2008

    • Author(s)
      中澤敬信、栗生俊彦、岡部繁男、山本雅
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of dendritic spine morphology by an NMDA receptor-associated RhoGAP, p250GAP.2007

    • Author(s)
      Nakazawa T., Kuriu T., Okabe S., Yamamoto T.
    • Organizer
      37^<th> ANNUAL MEETING Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2007-11-06
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://kp.bunri-u.ac.jp/kph15/Kuriupublication.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kp.bunri-u.ac.jp/kph15/Kuriupublication.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://kp.bunri-u.ac.jp/kph15/Kuriupublication.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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