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Excitatory and Inhibitory synapse distribution on cortical neurons

Research Project

Project/Area Number 20500300
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

KUBOTA Yoshiyuki  National Institute for Physiological Sciences, 大脳皮質機能研究系, 准教授 (90192567)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大脳皮質 / 非錐体細胞 / GABA / 3次元再構築 / 樹状突起 / シナプス / 錐体細胞 / 棘突起 / 興奮性シナプス / 抑制性シナプス
Research Abstract

Understanding the brain's circuit architecture is critical to elucidating its function. Recently, the inhibitory components of cortical circuits have received increased attention. We have found no significant difference of the GABA positive synapse density among different subtype of cortical nonpyramidal cells, although excitatory synapse inputs are found to distribute in different density among cortical nonpyramidal cell subtypes. We also found that excitatory thalamo-cortical afferent fibers are rarely innervated cortical parvalbumin positive cell dendrites and intra-cortical afferent fibers are richly innervated them.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (32 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Selective Coexpression of Multiple Chemical Markers Defines Discrete Populations of Neocortical GABAergic Neurons2011

    • Author(s)
      Kubota Y, Shigematsu N, Karube F, Sekigawa A, Kato S, Yamaguchi N, Hirai Y, Morishima M, Kawaguchi Y
    • Journal Title

      Cerebral Cortex (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective Coexpression of Multiple Chemical Markers Defines Discrete Populations of Neocortical GABAergic Neurons2011

    • Author(s)
      Kubota Y, Shigematsu N, Karube F, Sekigawa A, Kato S, Yamaguchi N, Hirai Y, Morishima M, Kawaguchi Y
    • Journal Title

      Cerebral Cortex

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Important factors for the three-dimensional reconstruction of neuronal structures from serial ultrathin sections.2009

    • Author(s)
      Kubota Y, Hatada S, Kawaguchi Y
    • Journal Title

      Frontiers in Neural Circuits Volume 3, Article 4.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Important factors for the three-dimensional reconstruction of neuronal structures from serial ultrathin sections2009

    • Author(s)
      Kubota Y, Hatada S, Kawaguchi Y
    • Journal Title

      Frontiers in Neural Circuits 3

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大脳皮質非錐体細胞へのシナプス入力分布2011

    • Author(s)
      窪田芳之
    • Organizer
      第88回日本生理学会、第116回日本解剖学会 合同大会日中韓シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 大脳皮質非錐体細胞へのシナプス入力分布2011

    • Author(s)
      Kubota Y
    • Organizer
      第88回日本生理学会、第116回日本解剖学会合同大会日中韓シンポジウム
    • Place of Presentation
      横浜(東日本大震災の為、誌上発表に変更)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dendritic dimensions and signal conduction properties of cortical nonpyramidal cells.2010

    • Author(s)
      Kubota Y, Karube F, Nomura M, Gulledge A, Mochizuki A, Kawaguchi Y
    • Organizer
      Annual Meeting Society For Neuroscience.
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Deadritic dimensions and signal conduction properties of cortical nonpyramidal cells2010

    • Author(s)
      Kubota Y, Karube F, Nomura M, Gulledge A, Mochizuki A, Kawaguchi Y
    • Organizer
      2010 Annual Meeting Society For Neuroscience.
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dendritic dimensions and signal conduction properties of cortical nonpyramidal cells2010

    • Author(s)
      窪田芳之
    • Organizer
      第33回日本神経科学大会 シンポジウム
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendritic dimensions and signal conduction properties of cortical nonpyramidal cells2010

    • Author(s)
      Kubota Y
    • Organizer
      第33回日本神経科学大会シンポジウム
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dendritic dimensions and signal conduction properties of cortical nonpyramidal cells.2010

    • Author(s)
      Kubota Y, Karube F, Nomura M, Gulledge A, Mochizuki A, Kawaguchi Y
    • Organizer
      第5回国際神経回路会議JST international meeting-Microcircuitry of Cortex.
    • Place of Presentation
      未来館(東京都)
    • Year and Date
      2010-06-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendtific dimensions and signal conduction properties of cxortical nonpyramidal cells2010

    • Author(s)
      Kubota Y, Karube F, Nomura M, Gulledge A, Mochizuki A, Kawaguchi Y
    • Organizer
      第5回国際神経回路会議JST international meeting"Microcircuitry of Cortex"
    • Place of Presentation
      未来館(東京都)
    • Year and Date
      2010-06-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dendritic dimensions and signal conduction properties of cortical nonpyramidal cells.2010

    • Author(s)
      Kubota Y, Karube F, Nomura M, Gulledge A, Mochizuki A, Kawaguchi Y
    • Organizer
      第4回国際神経回路会議JSPS international meeting-Signal Processing Mechanisms of Cortical Neurons.
    • Place of Presentation
      カヌチャリゾート(沖縄県)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendtific dimensions and signal conduction properties of cxortical nonpyramidal cells2010

    • Author(s)
      Kubota Y, Karube F, Nomura M, Gulledge A, Mochizuki A, Kawaguchi Y
    • Organizer
      第4回国際神経回路会議 JSPS international meeting Signal Processing Mechanisms of Cortical Neurons
    • Place of Presentation
      カヌチャリゾート(沖縄県)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Important factors for the three-dimensional reconstruction of neuronal structures from serial ultrathin sections.2009

    • Author(s)
      Kubota Y, Hatada S, Kawaguchi Y
    • Organizer
      Annual Meeting Society For Neuroscience.
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2009-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Important factors for the three-dimensional reconstruction of neuronal structures from serial ultrathin sections2009

    • Author(s)
      Yoshiyuki Kubota, Sayuri Hatada, Yasuo Kawaguchi
    • Organizer
      2009 Annual Meeting Society For Neuroscience
    • Place of Presentation
      アメリカ、シカゴ
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dendritic shape and EPSP conduction of cortical nonpyramidal cells2009

    • Author(s)
      Kubota Y, Karube F, Nomura M, Aoyagi T, Kawaguchi Y
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendritic shape and EPSP conduction of cortical nonpyramidal cells2009

    • Author(s)
      Yoshiyuki Kubota, Fuyuki Karube, Masaki Nomura, Toshio Aoyagi, Yasuo Kawaguchi
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋(国際会議場)
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dendritic morphology and signal conduction property of cortical nonpyramidal cells2009

    • Author(s)
      Kubota Y, Karube F, Nomura M, Aoyagi T, Kawaguchi Y
    • Organizer
      第36回国際生理学大会IUPS2009
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dendritic conductance is determined by its dimension in cortical nonpyramidal cells2009

    • Author(s)
      Kubota Y, Karube F, Nomura M, Kawaguchi Y
    • Organizer
      京都大学国際シンポジウム "Cellular Approaches to Neuronal Signal Processing"
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dendritic dimension and synapse density on dendrites and soma of various cortical nonpyramidal cells.2009

    • Author(s)
      窪田芳之
    • Organizer
      EMBO Workshop
    • Place of Presentation
      マヨルカ(スペイン)
    • Year and Date
      2009-06-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 大脳皮質非錐体細胞へのGABA陽性陰性シナプス入力2009

    • Author(s)
      窪田芳之
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山理科大学(岡山県)
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 大脳皮質非錐体細胞へのGABA陽性陰性シナプス入力2009

    • Author(s)
      窪田芳之
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dendritic dimension and synapse density on dendrites and soma of various cortical nonpyramidal cells.2009

    • Author(s)
      窪田芳之
    • Organizer
      脳と心のメカニズム 第9回 冬のワークショップ
    • Place of Presentation
      ルスツリゾート(北海道)
    • Year and Date
      2009-01-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendritic dimension and synapse density on dendrites and soma of various cortical nonpyramidal cells2009

    • Author(s)
      窪田芳之
    • Organizer
      脳と心のメカニズム 第9回冬のワークショップ Large-scale Simulations and Database in Neuroscience
    • Place of Presentation
      北海道ルスツリゾート
    • Year and Date
      2009-01-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dendritic morphology and signal conduction property of cortical nonpyramidal cells.2009

    • Author(s)
      Kubota Y, Karube F, Nomura M, Aoyagi T, Kawaguchi Y
    • Organizer
      第36回国際生理学大会 IUPS2009 シンポジウム"Mechanisms of dendritic signaling"
    • Place of Presentation
      京都国際会議場(京都府)
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendritic dimension and synapse density on dendrites and soma of various cortical nonpyramidal cells.2009

    • Author(s)
      Kubota Y, Karube F, Nomura M, Hatada S, Sekigawa A, Kawaguchi Y
    • Organizer
      京都大学国際シンポジウム"Cellular Approaches to Neuronal Signal Processing"
    • Place of Presentation
      京都大学(京都府)
    • Related Report
      2010 Final Research Report
  • [Presentation] Dendritic dimension and synapse density on dendrites and soma of various cortical nonpyramidal cells2009

    • Author(s)
      Yoshiyuki Kubota
    • Organizer
      EMBO Workshop
    • Place of Presentation
      スペイン、マヨルカ
    • Related Report
      2009 Annual Research Report
  • [Presentation] The excitatory and inhibitory synapse densities on various GABAergic nonpyramidal cells in the rat cerebral cortex.2008

    • Author(s)
      窪田芳之
    • Organizer
      Annual Meeting Society For Neuroscience.
    • Place of Presentation
      ワシントン(アメリカ)
    • Year and Date
      2008-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] The excitatory and inhibitory synapse densities on various GABAergic nonpyramidal cells in the rat cerebral cortex2008

    • Author(s)
      窪田芳之
    • Organizer
      the 38th annual meeting of the Society for Neuroscience
    • Place of Presentation
      ワシントン、米国
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] An excitatory and inhibitory synapse density on various GABAergic nonpyramidal cells in the rat cerebral cortex2008

    • Author(s)
      窪田芳之
    • Organizer
      第39回生理研国際コンファレンス
    • Place of Presentation
      生理学研究所、岡崎
    • Year and Date
      2008-11-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dendritic morphologies and synaptic innervation patterns of cortical nonpyramidal cells2008

    • Author(s)
      窪田芳之
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dendritic dimension and epsp conduction property of cortical nonpyramidal cells2008

    • Author(s)
      窪田芳之
    • Organizer
      理研-BSI統合能シンポジウム
    • Place of Presentation
      理化学研究所、和光
    • Year and Date
      2008-07-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] An excitatory and inhibitory synapse density on various GABAergic nonpyramidal cells in the rat cerebral corte.2008

    • Author(s)
      Kubota Y, Hatada S, Sekigawa A, Shigematsu N, Kawaguchi Y
    • Organizer
      第39回生理研国際シンポジウム"Frontiers of Biological Imaging Synergy of the Advanced Techniques"
    • Place of Presentation
      生理研(愛知県)
    • Related Report
      2010 Final Research Report
  • [Presentation] Excitatory and Inhibitory Synapse Densities on Various GABAergic Nonpyramidal Cells in the Rat Cerebral Cortex.2008

    • Author(s)
      Kubota Y, Hatada S, Sekigawa A, Kawaguchi Y
    • Organizer
      理研BSI-統合脳シンポジウム-Recent Advances in the Neural Circuit Analysis"
    • Place of Presentation
      理化学研究所(埼玉県)
    • Related Report
      2010 Final Research Report
  • [Presentation] 非錐体細胞の樹状突起の形態と機能的意義2008

    • Author(s)
      窪田芳之
    • Organizer
      第31回日本神経科学大会シンポジウム「大脳皮質と線条体の局所神経回路と神経細胞」
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2010 Final Research Report
  • [Book] 皮質局所神経回路の興奮性抑制性入力特性"ブレインサイエンス・レビュー2008"(伊藤正男・川合述史編集)2008

    • Author(s)
      窪田芳之
    • Publisher
      クバプロ、東京
    • Related Report
      2010 Final Research Report
  • [Book] 「皮質局所神経回路の興奮性抑制性入力特性」ブレインサイエンス・レビュー 2008(伊藤正男・川合述史編集)2008

    • Author(s)
      窪田芳之
    • Total Pages
      223
    • Publisher
      クバプロ
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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