Analysis of the role of IP_3 receptor in higher brain function

• Project/Area Number: 20500301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: HISATSUNE Chihiro The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 研究員 (10321803)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: calcium / IP_3R / brain / dystonia / conditional / knockout / mice / イノシトール3リン酸 / 脳 / 運動 / IP3 receptor / Inositol trisphosphate receptor / knockout mice / Ca^<2+> signal / Brain

Research Abstract

Inositol trisphosphate receptor (IP_3R1) is one of the important Ca^<2+> channels that release Ca^<2+> from the endoplasmic reticulum (ER). There are three subtypes of IP_3R so far, and IP_3R1 is a major subtype in the central nerves systems. In this study, we constructed several brain-specific IP_3R1 conditional IP_3R1 mice and analyzed the role of IP_3R1 in the higher brain function.

Research Products

• [Journal Article] Mechanism of ER stress-induced brain damage by IP_3 receptor. (2010)
  • Author(s): Higo T, Hamada K, Hisatsune C, Nukina N, Hashikawa T, Hattori M, Nakamura T, Mikoshiba K
  • Journal Title: Neuron. 68(5) Pages: 865-78
  • Peer Reviewed
• [Journal Article] Isolation of inositol 1,4,5-trisphosphate receptor-associating proteins and selective knockdown using RNA interference. (2010)
  • Author(s): Mizutani A, Kawaai K, Hisatsune C, Ando H, Michikawa T, Mikoshiba K
  • Journal Title: Methods Mol Biol. 645 Pages: 133-41
• [Journal Article] Mechanism of ER stress-induced brain damage by IP(3) receptor. (2010)
  • Author(s): Higo T, Hamada K, Hisatsune C, Nukina N, Hashikawa T, Hattori M, Nakamura T, Mikoshiba K.
  • Journal Title: Neuron Volume: 68 Pages: 865-878
  • Peer Reviewed
• [Journal Article] G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by inositol 1,4,5-triphosphate receptor-mediated Ca^<2+> signal regulation. (2009)
  • Author(s): Zhang S, Hisatsune C, Matsu-Ura T, Mikoshiba K
  • Journal Title: J Biol Chem. 284(42) Pages: 29158-69
  • Peer Reviewed
• [Journal Article] 80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity. (2009)
  • Author(s): Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K
  • Journal Title: J Biol Chem. 284 Pages: 372-80
  • Peer Reviewed
• [Journal Article] G-protein-coupled receptor kinase-interacting proteins inhibit apoptosis by Inositol 1, 4, 5-triphosphate receptor-mediated Ca2+ signal regulation (2009)
  • Author(s): Zhang S, et al.
  • Journal Title: J Biol Chem. 284 Pages: 29158-29169
  • Peer Reviewed
• [Journal Article] IP_3 receptor and Ca^<2+> signaling (2009)
  • Author(s): Hisatsune C, et al.
  • Journal Title: Handbook of Neurochemistry and Molecular Neurobiology (3^<rd> Edition) Pages: 566-575
• [Journal Article] 80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity (2009)
  • Author(s): Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K.
  • Journal Title: Journal of Biological Chemistry 284 Pages: 372-380
  • Peer Reviewed
• [Journal Article] The role of Ca^<2+> signaling in cell function with special reference to exocrine secretion. (2008)
  • Author(s): Mikoshiba K, Hisatsune C, Futatsugi A, Mizutani A, Nakamura T, Miyachi K
  • Journal Title: Cornea. 27 Suppl 1(Review)
• [Journal Article] Osteoblasts induce Ca^<2+> oscillation-independent NFATc1 activation during osteoclastogenesis. (2008)
  • Author(s): Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K
  • Journal Title: Proc Natl Acad Sci U S A. 105(25) Pages: 8643-8
  • Peer Reviewed
• [Journal Article] Predominant role of type 1 IP_3 receptor in aortic vascular muscle contraction. (2008)
  • Author(s): Zhou H, Nakamura T, Matsumoto N, Hisatsune C, Mizutani A, Iesaki T, Daida H, Mikoshiba K
  • Journal Title: Biochem Biophys Res Commun. 369(1) Pages: 213-9
  • Peer Reviewed
• [Journal Article] The role of Ca2+ signaling in cell function with special reference to exocrine secretion (2008)
  • Author(s): Mikoshiba K, Hisatsune C, Futatsugi A, Mizutani A, Nakamura T, Miyachi K.
  • Journal Title: Cornea Suppl 1
• [Journal Article] Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. (2008)
  • Author(s): Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K.
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 8643-8
  • Peer Reviewed
• [Book] Handbook of Neurochemistry and Molecular Neurobiology(Chapter25 : Signal molecules and Calcium : IP_3 receptor and Ca^<2+> signaling) (2009)
  • Author(s): Chihiro Hisatsune, Katsuhiko Mikoshiba