Analysis of the role of IP_3 receptor in higher brain function
| Project/Area Number |
20500301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HISATSUNE Chihiro The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 研究員 (10321803)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | calcium / IP_3R / brain / dystonia / conditional / knockout / mice / イノシトール3リン酸 / 脳 / 運動 / IP3 receptor / Inositol trisphosphate receptor / knockout mice / Ca^<2+> signal / Brain |
|---|
| Research Abstract |
Inositol trisphosphate receptor (IP_3R1) is one of the important Ca^<2+> channels that release Ca^<2+> from the endoplasmic reticulum (ER). There are three subtypes of IP_3R so far, and IP_3R1 is a major subtype in the central nerves systems. In this study, we constructed several brain-specific IP_3R1 conditional IP_3R1 mice and analyzed the role of IP_3R1 in the higher brain function.
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Report
(4 results)
Research Products
(14 results)
