| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
After the biochemical examination of SDS-insoluble materials of the brains with Alzheimer's disease, we identified human α-Synuclein by cDNA cloning. Later, some missense mutations of the gene of α-Synuclein were found in the cases with familial Parkinson's disease. α-Synuclein turned out to be the major component of Lewy bodies. In the present studies, we identified that α-Synuclein is localized in the inner membrane of neuronal mitochondria.
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