| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We found that ATBF1 expression was up-regulated in the brains of AD and AD model mouse (Tg2576). Moreover, our in vitro studies showed that Aβ and DNA-damaging drugs, namely, etoposide and homocysteine, increased the ATBF1 expression level in primary rat cortical neurons ; this increase, in turn, may activate ATM signaling responsible for neuronal death. In addition, ATBF1 enhanced Aβ production in HEK293T cells transiently cotransfected with ATBF1 and APP via its interaction with APP.
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