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Involvement of Hox genes in subgroup specific motoneuron death

Research Project

Project/Area Number 20500311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionFukushima Medical University

Principal Investigator

YAGINUMA Hiroyuki  Fukushima Medical University, 医学部, 教授 (90230193)

Co-Investigator(Kenkyū-buntansha) NISHIYAMA Keiji  福島県立医科大学, 医学部, 准教授 (10106354)
HOMMA Shunsaku  福島県立医科大学, 医学部, 講師 (20261795)
MASUDA Tomoyuki  福島県立医科大学, 医学部, 助教 (70372828)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords発生・分化 / 運動神経細胞 / 神経細胞死 / ホックス遺伝子 / 転写因子 / 発生 / ニワトリ胚 / プログラム細胞死 / アポトーシス / 頚髄 / 運動神経 / 分化 / ホメオボックス / Foxp1 / 鳥類
Research Abstract

Major results of the present study are as follows:
(1) The rostral ends of HoxC5 and HoxC6 expressions well correspond to the rostral and caudal borders of the segments with early cervical motoneuron death, respectively.
(2) FoxP1 transcription factor that is known to cooperate with Hox genes for inducing specific motoneuron subgroups is found in dying motoneurons. However, functional significance of FoxP1 in early cervical motoneuron death has not been elucidated yet.
(3) In the avian cervical cord, there are branchial motoneurons that express Phox2b and never die during the period of early cervical motoneuron death.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Osumi N, Kaibuchi K, Kobayashi K Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons.2011

    • Author(s)
      Kobayashi K, Masuda T, Takahashi M, Miyazaki J, Nakagawa M, Uchigashima M, Watanabe M, Yaginuma H
    • Journal Title

      Eur J Neurosci 33(4)

      Pages: 612-21

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein.2011

    • Author(s)
      Kato S, Kobayashi K, Inoue K, Kuramochi M, Okada T, Yaginuma H, Morimoto K, Shimada T, Takada M, Kobayashi K.
    • Journal Title

      Hum Gene Ther. 22(2)

      Pages: 197-206

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons.2011

    • Author(s)
      Kobayashi K, Masuda T, Takahashi M, Miyazaki J, Nakagawa M, Uchigashima M, Watanabe M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K
    • Journal Title

      Eur J Neurosci.

      Volume: 33 Pages: 612-621

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein.2011

    • Author(s)
      Kato S, Kobayashi K, Inoue K, Kuramochi M, Okada T, Yaginuma H, Morimoto K, Shimada T, Takada M, Kobayashi K
    • Journal Title

      Hum Gene Ther

      Volume: 22 Pages: 197-206

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.2009

    • Author(s)
      Masuda T, Kai N, Sakuma C, Kobayashi K, Koga H, Yaginuma H.
    • Journal Title

      Brain Res 1249

      Pages: 61-67

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.2009

    • Author(s)
      Homma S, Shimada T, Hikake T, Yaginuma H
    • Journal Title

      Gene Expr Patterns. 9(1)

      Pages: 1-26

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin peptide YIGSR and its receptor regulate sensory axonal response to the chemoattractive guidance cue in the chick embryo.2009

    • Author(s)
      Masuda T, Sakuma C, Kobayashi K, Kikuchi K, Soda E, Shiga T, Kobayashi K, Yaginuma H.
    • Journal Title

      J Neurosci Res. 87

      Pages: 353-359

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.2009

    • Author(s)
      Homma S, Shimada T, Hikake T, Yaginuma H.
    • Journal Title

      Gene Expr Patterns. 9

      Pages: 1-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.2009

    • Author(s)
      Masuda T, Kai N, Sakuma C, Kobayashi K, Koga H, Yaginuma H.
    • Journal Title

      Brain Res.2009 16 ; 1249 : 61-7. 16

      Pages: 61-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.2008

    • Author(s)
      Masuda T, Watanabe K, Sakuma C, Ikenaka K, Ono K, Yaginuma H.
    • Journal Title

      J Neurosci. 28(41)

      Pages: 10380-10385

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.2008

    • Author(s)
      Masuda T, Watanabe K, Sakuraa C, Ikenaka K, Ono K, Yaginuma H.
    • Journal Title

      J Neurosci. 28

      Pages: 10380-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lenhosse'k-Cajalニューロン(後根経由で軸索を出す運動ニューロン)の投射先と発生について2010

    • Author(s)
      八木沼洋行
    • Organizer
      日本解剖学会第56回東北・北海道連合支部学術集会
    • Place of Presentation
      旭川
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Lenhosse'k-Cajailニューロン(後根経由で軸索を出す運動ニューロン)の投射先と発生について2010

    • Author(s)
      八木沼洋行、小林信巳
    • Organizer
      日本解剖学会第56回東北・北海道連合支部学術集会
    • Place of Presentation
      旭川
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経系のプログラム細胞死期のおけるISLR2の発現様式2010

    • Author(s)
      本間俊作
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 発生課程の運動ニューロンの死に顔2010

    • Author(s)
      八木沼洋行
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスの脊髄運動ニューロンの発生分化に関わる転写因子と細胞死について2010

    • Author(s)
      西山慶治
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 発生過程の運動神経細胞の死に顔2010

    • Author(s)
      八木沼洋行
    • Organizer
      第115回日本解剖学会 全国学術集会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頚髄特異的な早期運動神経細胞死の決定に関与するFoxp12009

    • Author(s)
      八木沼洋行
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 頚髄特異的な早期運動神経細胞死の決定に関与するFoxP12009

    • Author(s)
      八木沼洋行, 本間俊作, 西山慶治, 増田知之, 島田孝子, 佐久間千恵
    • Organizer
      日本解剖学会全国学術総会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.fmu.ac.jp/cms/anatomy1/index_html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.fmu.ac.jp/kenkyu/Profiles/7/0000657/profile.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.fmu.ac.jp/kenkyu/Profiles/7/0000657/profile.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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