The regeneration of the central autonomic descending pathways-comparative aspects

• Project/Area Number: 20500312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Yokohama City University
• Principal Investigator: FUNAKOSHI Kengo 横浜市立大学, 大学院・医学研究科, 教授 (60291572)
• Co-Investigator(Renkei-kenkyūsha): ATOBE Yoshitoshi 横浜市立大学, 大学院・医学研究科, 助教 (60264602) ; NAKANO Masato 岩手医科大学, 解剖学講座, 助教 (50237351)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 神経再生 / 神経可塑性 / 自律神経系

Research Abstract

Although the fibrous scar is formed in the lesion site after the spinal hemisection of the goldfish, many tubules invade the fibrous scar from both rostral and caudal sides of the scar, and eventually bridge the scar. Accordingly, regenerating axons invading the tubules pass the scar. The tubules that induce growth of the regenerating axons might be derived from the blood vessels. In mammals, on the other hand, the structure of the fibrous scar seems to be a factor that impedes axonal regeneration

Research Products

• [Journal Article] Adult neurogenesis with 5-HT expression in lesioned goldfish spinal cord (2008)
  • Author(s): Takeda A、Nakano M、Goris RC、Funakoshi K
  • Journal Title: neurosciecne Volume: Vol.151, No.4 Pages: 1132-1141
  • Peer Reviewed
• [Journal Article] Adult neurogenesis with 5-HT expression in lesioned goldfish spinal cord (2008)
  • Author(s): Takeda A, Nakano M, Goris RC, Funakoshi K
  • Journal Title: Neuroscience 151 Pages: 1132-1141
  • Peer Reviewed
• [Presentation] Comparative study of axonal regeneration beyond scar tissue after spinal injury (2010)
  • Author(s): Kengo Funakoshi
  • Organizer: Bit's 3^<rd> Annual World Congress of Regenerative Medicine & Stem Cells 2010
  • Place of Presentation: Shanghai,中華人民共和国(招待講演)
  • Year and Date: 2010-12-05
• [Presentation] Comparative anatomy of the descending motor pathways and their regenerative capacity (2010)
  • Author(s): Kengo Funakoshi
  • Organizer: Bit's 1^<st> Annual World Congress of NeuroTalk 2010
  • Place of Presentation: Singapore(招待講演)
  • Year and Date: 2010-06-27
• [Presentation] キンギョ脊髄切断後の再生過程における線維性瘢痕の変化 (2010)
  • Author(s): 武田昭仁, 跡部好敏, 船越健悟
  • Organizer: 第115回日本解剖学会全国学術集会
  • Place of Presentation: 第115回日本解剖学会全国学術集会
  • Year and Date: 2010-03-30
• [Presentation] 機能的な回復が認められた脊髄損傷Ratの組織学的検討 (2010)
  • Author(s): 跡部好敏, 武田昭仁, 吉川輝, 船越健悟
  • Organizer: 第115回日本解剖学会全国学術集会
  • Place of Presentation: 第115回日本解剖学会全国学術集会
  • Year and Date: 2010-03-30
• [Presentation] キンギョ脊髄切断後の再生過程における線維性瘢痕の変化 (2010)
  • Author(s): 武田昭仁, 跡部好敏, 船越健悟
  • Organizer: 日本解剖学会第115回全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] 機能的な回復が認められた脊髄損傷Ratの組織学的検討 (2010)
  • Author(s): 跡部好敏, 武田昭仁, 吉川輝, 船越健悟
  • Organizer: 日本解剖学会第115回全国学術集会
  • Place of Presentation: 盛岡
• [Presentation] Comparative anatomy of the descending motor pathways and their regenerative capacity (2010)
  • Author(s): Funakoshi K
  • Organizer: Bit's 1^<st> Annual World Congress of NeuroTalk 2010
  • Place of Presentation: Singapore
• [Presentation] Comparative study of axonal regeneration beyond scar tissue after spinal injury (2010)
  • Author(s): Funakoshi K
  • Organizer: Bit's 3^<rd> Annual World Congress of Regenerative Medicine & Stem Cells 2010
  • Place of Presentation: Shanghai
• [Presentation] Mechanism of axonal regrowth beyond the scar after transection of the goldfish spinal cord (2008)
  • Author(s): Takeda A, Nakano M, Atobe Y, Goris RC, Funakoshi K
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: ワシントンDC
  • Year and Date: 2008-11-15
• [Presentation] Axonal regeneration and neurogenesis in the goldfish spinal cord (2008)
  • Author(s): Funakoshi K
  • Organizer: 日本解剖学会関東支部第18回懇話会・シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-06-28
• [Presentation] Axonal regeneration and neurogenesis in the goldfish spinal cord (2008)
  • Author(s): Funakoshi K
  • Organizer: 日本解剖学会関東支部第18回懇話会・シンポジウムDevelopment of the central nervous system
  • Place of Presentation: Tokyo
• [Presentation] Mechanism of axonal regrowth beyond the scar after transection of the goldfish spinal cord (2008)
  • Author(s): Takeda A, Nakano M, Atobe Y, Goris RC, Funakoshi K
  • Organizer: Society for Neuroscience 38^<th> Annual Meeting
  • Place of Presentation: Washington DC
• [Remarks]