| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We examined the sexual behavior in male wild-type and metabotropic glutamate receptor subtype 7 knockout mice (mGluR7 KO) littermates. Wefound that mGluR7 KO has difficulty in ejaculation. Furthermore, we also examined the aggressive behavior of these mice, using a resident-intruder paradigm. Wild-type micedisplayed intense aggression against olfactory bulbectomized intruders. In comparison, mGluR7 KO showed significantly reduced levels of aggression. mGluR7 KO showedreduced plasma testosterone level. Castration reduced both sexual and aggressive behavior to equivalent low levels in both wild type and mGluR7 KO. Testosterone replacement restored these behaviors to pre-castration levels in both genotypes.
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