DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain

• Project/Area Number: 20500314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Nara Medical University
• Principal Investigator: TATSUMI Kouko Nara Medical University, 医学部, 講師 (90208033)
• Co-Investigator(Kenkyū-buntansha): AKIO Wanaka 奈良県立医科大学, 医学部, 教授 (90210989)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: アストロサイト / コンドロイチン硫酸 / DACS / 細胞外マトリックス / テネイシンR

Research Abstract

We found a novel CSPG-containing extracellular matrix structure in the adult cerebral cortex and named it Dandelion clock-like structure (DACS) for its morphology reminiscent of dandelion clock. Immunohistochemical analysis showed that DACS is produced by a novel specific subset of astrocytes and is conserved among the species higher than rodents. These findings suggested that DACS participate in higher function of brain.

Research Products

• [Journal Article] Localization of chondroitin sulfate proteo-glycan versican in adult brain with special reference to large projection neurons. (2008)
  • Author(s): Horii-Hayashi N, Okuda H, Tatsumi K, Ishizaka S, Yoshikawa M, Wanaka A.
  • Journal Title: Cell Tissue Res. 334(2) Pages: 163-177
  • Peer Reviewed
• [Journal Article] DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain. (2007)
  • Author(s): Tatsumi K, Hayashi N, Okuda H, Yoshikawa M, Ishizaka S, Miyata S, Manabe T, Wanaka A.
  • Journal Title: Biochem.Biophis.Res.Commun. 364(2) Pages: 410-415
  • Peer Reviewed
• [Presentation] Dacs, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain (2008)
  • Author(s): 辰 巳 晃 子
  • Organizer: 日本神経化学会総会 シンポジウム
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-11
• [Presentation] DACS, a novel matrix structure composed of chondroitin sulfate proteo- glycan in the brain. (2008)
  • Author(s): 辰巳晃子、堀井-林謹子、奥田洋明、和中明生
  • Organizer: 第51回日本神経化学会総会(シンポジウム)
  • Place of Presentation: 富山
• [Presentation] DACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain. (2008)
  • Author(s): 辰巳晃子・林 謹子、奥田洋明、宮田清司、眞部孝幸、和中明生
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 成熟脳の新しい細胞外基質構造DACSについて (2007)
  • Author(s): 和中明生、辰巳晃子、堀井-林謹子、奥田洋明
  • Organizer: 第313回大阪大学神経科学懇話会
  • Place of Presentation: 大阪
• [Remarks] ホームページ等