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Roles of the microtubule anchor on neuronal morphogenesis

Research Project

Project/Area Number 20500315
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionSophia University

Principal Investigator

HAYASHI Kensuke  上智大学, 理工学部, 教授 (50218567)

Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords神経発生 / 分化 / 異常 / 神経細胞 / 微小管 / 細胞骨格 / 細胞・組織 / 神経科学 / 脳・神経 / 発生・分化 / 樹状突起 / 細胞移動 / 細胞極性 / 徴小管
Research Abstract

Morphology of neurons is supported by microtubules. The unique arrangement of microtubules is responsible to the unique shape of neurons. In this study, we found that the centrosome, which generates microtubules has distinct molecular components and function in neurons. Neuronal centrosomes lacked ninein, which is a microbule anchor protein, and microtubule release form the centrosome was important for process elongation.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2012 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Remarks (5 results)

  • [Journal Article] Rear-side Localization of the Centrosome in Migrating Neuroblastoma Neuro-2a Cells and Its Roles in Process Elongation2012

    • Author(s)
      Kawabata W, Yonezawa S, Hayashi K
    • Journal Title

      Develop. Neurosci

      Volume: (in press) Issue: 1 Pages: 20-29

    • DOI

      10.1159/000338599

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of plastid movement in the pollen tube of Arabidopsis thaliana2012

    • Author(s)
      Fujiwara MT, Yoshioka Y, Hirano T, Kazama Y, Abe T, Hayashi K, Itoh R
    • Journal Title

      Plant Signal Behav

      Volume: 7 Pages: 34-37

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of plastid movement in the pollen tube of Arabidopsis thaliana2012

    • Author(s)
      Fujiwara MT, 他
    • Journal Title

      Plant Signal Behav.

      Volume: 7 Pages: 34-37

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rear-side Localization of the Centrosome in Migrating Neuroblastoma Neuro-2a Cells and Its Roles in Process Elongation2012

    • Author(s)
      Kawabata W, 他
    • Journal Title

      Develop.Neurosci.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relocalization of a microtubule-anchoring protein, ninein, from the centrosome to dendrites during differentiation of mouse neurons2009

    • Author(s)
      Ohama Y, Hayashi K
    • Journal Title

      Histochem. Cell Biol

      Volume: 132 Issue: 5 Pages: 515-524

    • DOI

      10.1007/s00418-009-0631-z

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relocalization of a microtubule-anchoring protein, ninein, from the centrosome to dendrites during differentiation of mouse neurons.2009

    • Author(s)
      Ohama Y, Hayashi K.
    • Journal Title

      Histochem.Cell Biol. 132

      Pages: 515-524

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Relocalization of a microtubule-anchoring protein, ninein, from the centrosome to dendrites during differentiation of mouse neurons2009

    • Author(s)
      大浜勇作, 林謙介
    • Journal Title

      Histochem. Cell Biol. 132

      Pages: 515-524

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 移動性ニューロンの先導突起形成とGSK32010

    • Author(s)
      林、新村、網中
    • Organizer
      日本神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 移動性ニューロンの先導突起形成とGSK32010

    • Author(s)
      林謙介、新村友里、網中裕一
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 神経系細胞Neuro2aの細胞移動による突起形成2009

    • Author(s)
      河端渉, 林謙介
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニューロンの樹状突起形成における微小管アンカー蛋白の関与2009

    • Author(s)
      平田一人, 大浜勇作, 林謙介
    • Organizer
      日本動物学会第80回大会
    • Place of Presentation
      静岡市
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Downregulation of Ninein at the Apical Side of Neuroepithelial Cells of the Pax6 Mutant2009

    • Author(s)
      Shinohara H., 他
    • Organizer
      日本発生生物学会42回大会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経細胞の樹状突起形成と微小管極性2009

    • Author(s)
      林謙介
    • Organizer
      日本顕微鏡学会関東支部
    • Place of Presentation
      東京
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニューロンの樹状突起形成における微小管アンカー蛋白の関与2009

    • Author(s)
      平田一人、大浜勇作、林謙介
    • Organizer
      日本動物学会第80回静岡大会
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 神経系細胞Neuro2aの細胞移動による突起形成2009

    • Author(s)
      河端渉、林謙介
    • Organizer
      日本動物学会第80回静岡大会
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 高い移動能を有する内側基底核原基ニューロンの極性形成2008

    • Author(s)
      新村友里、林謙介
    • Organizer
      第79回日本動物学会大会
    • Place of Presentation
      福岡大学
    • Year and Date
      2008-09-05
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 高い移動能を有する内側基底核原基ニューロンの極性形成2008

    • Author(s)
      新村友里, 林謙介
    • Organizer
      日本動物学会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-09-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Gamma tubulin and microtubule-anchor protein in the dendrite development2008

    • Author(s)
      大浜勇作, 平田一人, 林謙介
    • Organizer
      日本発生生物学会
    • Place of Presentation
      徳島市
    • Year and Date
      2008-05-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Downregulation of Ninein at the Apical Side of Neuroepithelial Cells of the Pax6 Mutant2008

    • Author(s)
      Hiroshi Shinohara, Kensuke Hayashi, Takai Miyata, Masanori Takahashi, Noriko Osumi
    • Organizer
      第42回日本発生生物学会大会
    • Place of Presentation
      新潟、朱鷺メッセ
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] Gamma tubulin and microtubule-anchor protein in the dendrite development2008

    • Author(s)
      Yusaku Ohama, Kazuto Hirata, Kensuke Hayashi
    • Organizer
      第42回日本発生生物学会大会
    • Place of Presentation
      新潟朱鷺メッセ
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://pweb.cc.sophia.ac.jp/khayashi/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://pweb.cc.sophia.ac.jp/khayashi/lab.html

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://pweb.cc.sophia.ac.jp/khayashi/lab.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://pweb.cc.sophia.ac.jp/khayashi/lab.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://pweb.cc.sophia.ac.jp/khayashi/lab.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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