Studies on the mechanism underlying the promotion of axonal regeneration by cell transplantation into the central nervous system lesion site
| Project/Area Number |
20500318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
KAWANO Hitoshi Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 副参事研究員 (20161341)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Junko 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (20142151)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 中枢神経系 / 損傷 / 細胞移植 / 神経再生 / グリア瘢痕 / 線維性瘢痕 / プロテオグリカン / 線維芽細胞 / アストロサイト / TGF-β / 脳 / ドーパミン神経路 / 嗅球グリア / 瘢痕 / コラーゲン |
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| Research Abstract |
Transplantation of olfactory ensheathing cells (OEC) into the lesion site of the CNS suppressed the formation of the fibrotic scar (Teng et al., 2008 ; Teng et al., 2010). Receptors for transforming growth factor-ss (TGF-ss) were expressed in meningeal fibroblasts which formed the fibrotic scar after brain injury (Komuta et al., 2010), and an inhibitor of TGF-ss suppressed the fibrotic scar formation (Yoshioka et al., 2011). When TGF-ss was added to coculute of astrocytes and fibroblasts, cell clusters which resembled the fibrotic scar were formed (Kimura-Kuroda et al., 2010). These results suggests that TGF-ss which increases after CNS injury is involved in the fibrotic scar formation.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] The transcriptional repressor RP58 is crucial for proper cell-division patterning and neuronal survival in developing cortex2009
Author(s)
Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M
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Journal Title
Dev.Biol. 331
Pages: 140-151
Related Report
Peer Reviewed
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