L-plastin ; the possibility as a surrogate marker of polyglutamine diseases.

• Project/Area Number: 20500322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Niigata University
• Principal Investigator: TOYOSHIMA Yasuko Niigata University, 脳研究所, 助教 (20334675)
• Co-Investigator(Kenkyū-buntansha): ONODERA Osamu 新潟大学, 脳研究所, 准教授 (20303167) ; TAKAHASHI Hitoshi 新潟大学, 脳研究所, 教授 (90206839)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ポリグルタミン病 / L-プラスチン / 治療予測マーカー / 脳神経疾患病理学 / 脳神経疾患 / 病理学

Research Abstract

L-plastin is a protein involved in actin filament organization and endocytotic processes. We found that the expression of L-plastin increased in the brains of polyglutamine diseases. We examined the relations about the L-plastin and polyglutamine. L-plastin was shown to come to have much expression in the progress of several weeks in vitro. It is thought that L-plastin may be related with a phenomenon to need time before polyglutamine disease develops.

Research Products

• [Journal Article] Involvement of Onuf's nucleus in Machado-Joseph disease : A morphometric and immunohistochemical study (2010)
  • Author(s): Shimizu H., Yamada M., Toyoshima Y, et al.
  • Journal Title: Acta Neuropathologica 120 Pages: 439-448
  • Peer Reviewed
• [Journal Article] Treatment-responsive opsoclonus-ataxia associated with ovarian teratoma (2010)
  • Author(s): Kawachi I, Saji E, Toyoshima Y, et al.
  • Journal Title: Journal of Neurology, Neurosurgery & Psychiatry 81 Pages: 581-582
  • Peer Reviewed
• [Journal Article] Involvement of Onufs nucleus in Machado-Joseph disease : A morphometric and immunohistochemical study (2010)
  • Author(s): Shimizu H., Yamada M., Toyoshima Y, et al.
  • Journal Title: Acta Neuropathologica Volume: 120 Pages: 439-448
  • Peer Reviewed
• [Journal Article] Pathological and immunological profiles of a limited form of neuromyelitis optica (2009)
  • Author(s): Yanagawa K, Kawachi I, Toyoshima Y, et al.
  • Journal Title: Neurology 73 Pages: 1628-1637
  • Peer Reviewed
• [Journal Article] SCA17 Clinical Neuroscience (2009)
  • Author(s): 豊島靖子、高橋均
  • Journal Title: 27 Pages: 1334-1335
• [Journal Article] Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease (2009)
  • Author(s): Tan CF, Yamada M, Toyoshima Y, et al.
  • Journal Title: Acta Neuropathol 118 Pages: 553-560
  • Peer Reviewed
• [Journal Article] Sporadic amyotrophic lateral sclerosis : Widespread multisysytem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator. (2009)
  • Author(s): Nishihira Y, Tan CF, Toyoshima Y, et al.
  • Journal Title: Neuropathology 29 Pages: 689-696
  • Peer Reviewed
• [Journal Article] Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death. (2009)
  • Author(s): Tada M, Kakita A, Toyoshima Y, et al.
  • Journal Title: Brain 132 Pages: 1810-1819
  • Peer Reviewed
• [Journal Article] Cerebellar Involvement in Progressive Supranuclear Palsy : A Clinicopathological Study. (2009)
  • Author(s): Kanazawa M, Shimohata T, Toyoshima Y,
  • Journal Title: Mov Disord 24 Pages: 1312-1318
  • Peer Reviewed
• [Journal Article] SCA17 (2009)
  • Author(s): 豊島靖子
  • Journal Title: Clinical Neuroscience 12 Pages: 1334-1335
• [Journal Article] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic (2008)
  • Author(s): Takahashi T, Kikuchi S, Katada S, Nagai Y, Nishizawa M, Onodera O.
  • Journal Title: Hum Mol Genet 17 Pages: 345-56
  • Peer Reviewed
• [Journal Article] Spinocerebellar Ataxia Type 17 (SCA17). (2008)
  • Author(s): Toyoshima Y, Onodera O, Yamada M, et al.
  • Journal Title: GeneReviews at GeneTests
  • URL: http://www.genetests.org
  • Peer Reviewed
• [Journal Article] Vertebral basilar system dolichoectasia with marked infiltration of IgG4-containing plasma cells : A manifestation of IgG4-related disease?
  • Author(s): Toyoshima Y, Emura I, Umeda Y, et al.
  • Journal Title: Neuropathology in press
• [Presentation] Machado-Joseph病におけるTDP-43の異常発現 (2009)
  • Author(s): 豊島靖子
  • Organizer: 第50回日本神経病理学会総会学術研究会
  • Place of Presentation: サンポール高松(香川県)
  • Year and Date: 2009-06-06
• [Remarks] ホームページ等