Posttranscriptional regulation of the expression of Spinal Muscular Atrophy associated genes SMN1/2

Research Project

Project/Area Number	20500326
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Nerve anatomy/Neuropathology
Research Institution	Jikei University School of Medicine
Principal Investigator	KASHIMA Tsuyoshi Jikei University School of Medicine, 医学部, 助教 (30459622)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	RNA結合蛋白質 / RNA干渉 / 3'-非翻訳領域 / 翻訳調節 / mRNAの安定化 / 翻訳制御 / スプライシング / 脊髄性筋萎縮症 / 3'非翻訳領域 / 神経変性疾患 / モーターニューロン病
Research Abstract	We found that hnRNP A2 specific RNAi treatment decreased the protein level of SMN in Spinal Muscular Atrophy (SMA) derived fibroblast cells. Our analyses indicated that this effect was controlled at translational level. This result was suggested that the molecular interaction between SMN mRNA and hnRNP A2 might be a new molecular target for developing a therapeutic method for SMA.

Report

(4 results)