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The analysis of chemokines and Epstein-Barr virus in the tumor genesis of primary central nervous system lymphomas

Research Project

Project/Area Number 20500327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKurume University

Principal Investigator

YASUO Sugita  Kurume University, 医学部, 教授 (80216316)

Co-Investigator(Kenkyū-buntansha) 大島 孝一  久留米大学, 医学部, 教授 (50203766)
寺崎 瑞彦  久留米大学, 医学部, 准教授 (70320223)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords神経科学 / 脳神経疾患 / 病理学
Research Abstract

In this study, Epstein-Barr virus (EBV) was implicated in the pathogenesis of primary central nervous system lymphomas (PCNLs) in immunocompetent hosts (elderly immunocompetent patients ; age≧60 years). Histologically, all cases were diagnosed as diffuse large B-cell lymphoma with extensive necrosis. EBV subtyping-PCR analysis demonstrated that many cases were EBNA 2A type and showed 30-bp LMP-1 deletion on PCR analysis. These results indicate that LMP-1 deletion may have more potent tumor-promoting activity than EBV containing the full-size LMP-1 gene in the pathogenesis of PCNLs in immunocompetent hosts. In addition, some EBV subtypes may show more potent tumor-promoting activity. Regarding chemokines, we have shown that CXCL12/CXCR4 was frequently expressed in PCNLs and other brain cells. Thus, the results suggest that the CXCL12/CXCR4 signaling mediates PCNLs development.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Book (1 results)

  • [Journal Article] CXCL12/CXCR4 signaling in malignant brain tumors : a potential pharmacological therapeutic targets.2011

    • Author(s)
      Terasaki M, Sugita Y, Arakawa F, Okada Y, Miyagi N, Ohshima K, Shigemori M
    • Journal Title

      Brain Tumor Pathol 28

      Pages: 89-97

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CXCL12/CXCR4 signaling in malignant brain tumors : a potential pharmacological therapeutic target2011

    • Author(s)
      寺崎瑞彦, 杉田保雄, 大島孝一, 他3名
    • Journal Title

      Brain Tumor Pathology

      Volume: 28 Pages: 159-163

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus-associated primary central nervous system lymphomas in elderly patients : analysis for latent membrane protein-1 oncogene deletion and EBNA-2 strain typing.2010

    • Author(s)
      Sugita Y, Terasaki M, Niino D, Ohshima K, Arakawa F, Shigemori M, Sato Y, Asano N
    • Journal Title

      J Neurooncol 100

      Pages: 271-279

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus-associated primary central nervous lymphomas in immunocompetent elderly patients analysis for latent membrane protein-1 oncogene deletion and EBNA-2 strain typing2010

    • Author(s)
      杉田保雄, 寺崎瑞彦, 大島孝一, 他5名
    • Journal Title

      Journal of Neurooncology

      Volume: 100 Pages: 271-279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases.2009

    • Author(s)
      Fukushima S, Terasaki M, Sakata K, Miyagi N, Kato S, , Sugita Y, Shigemori M
    • Journal Title

      Brain Tumor Pathol 26

      Pages: 51-57

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of CXCL12 on psuedopalisading cells and proliferating microvessels in glioblastomas : An accelerated growth factor in glioblastomas.2009

    • Author(s)
      Komatani H, Sugita Y, Arakawa F,Ohshima K, Shigemori M
    • Journal Title

      Int J of Oncol 34

      Pages: 665-672

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 中枢原発悪性リンパ腫の増殖・血管新生におけるケモカインCXCL12,CXCL13の役割2011

    • Author(s)
      杉田保雄,新野大介,岡田洋介、中村晋彦,大島孝一
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Epstein-Barr virus-associated primary central nervous system lymphomas in elderly patients.2010

    • Author(s)
      Sugita Y, Niino D, Ohshima K, Arakawa F
    • Organizer
      86th Annual meeting of the American Association of Neuropathologists
    • Place of Presentation
      Philadelphia
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Epstein-Barr virus-associated primary central nervous lymphomas in immunocompetent elderly patients2010

    • Author(s)
      杉田保雄
    • Organizer
      American Association of Neuropathologist 2010 Annual meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Primary central nervous system lymphomas associated with Epstein-Barr virus in an immunocompetent host2008

    • Author(s)
      Sugita Y, Terasaki M, Niino D, Ohshima K, Arakawa F, Shigemori M, Ito M
    • Organizer
      The clinicopathological features of 5 cases.第1回 アジア神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Primary central nervous lymphomas in an immunocompetent host associated with Epstein-Barr virus : The clinicopathological features.2008

    • Author(s)
      杉田保雄
    • Organizer
      First congress of Asian society of Neuropathology.
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Book] Tumors of the Central Nervous System(Hayat MA(eds))(role of CXCL12 chemokine.)2011

    • Author(s)
      Sugita Y Glioblastomas
    • Publisher
      Springer, New York
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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