• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Nature of Guam-ALS and mechanism of degeneration of the motor neurons examined by the specific anti-phosphorylated TDP-43 antibody

Research Project

Project/Area Number 20500330
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

HASHIMOTO Tomoyo  Tokyo Metropolitan Organization for Medical Research, 医学部, 委嘱講師 (70425685)

Co-Investigator(Kenkyū-buntansha) OYANAGI Kiyomitsu  信州大学, 医学部, 教授 (00134958)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsTDP-43 / 筋萎縮性側索硬化症 / パーキンソン認知症 / 神経変性疾患
Research Abstract

To elucidate the nature of the amyotrophic lateral sclerosis (ALS) and the parkinsonism-dementia complex (PDC) of Guam, the authors examined the biochemical features of the TDP-43 (TAR-DNA binding protein-43 K dalton) and the progression pattern of the phosphorylated (p)-TDP-43 immunopositive inclusions in the brains and spinal cords of ALS, PDC and controls of Guam, and Japanese classic ALS, controls, and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). The results indicated that Guam ALS and PDC are basically different diseases, and Guam ALS occurs initially as classic ALS.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Book (5 results)

  • [Journal Article] 基本的な脳標本の作製法2011

    • Author(s)
      橋本智代, 小柳清光
    • Journal Title

      臨床検査学雑誌 (印刷中)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Survival motor (SMN) protein in the spinal anterior horn cells of patient with sporadic amyotrophic lateral sclerosis.2011

    • Author(s)
      Piao Y, Hashimoto T, Takahama S, Kakita A, Komori T, Morita T, Takahashi H, Mizutani T, Oyanagi K
    • Journal Title

      Brain Research 1372

      Pages: 152-159

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 異常TDP-43蓄積と神経細胞死:筋萎縮性側索硬化症(ALS)と前頭側頭葉変性症(FTLD)における観察と考察2011

    • Author(s)
      小柳清光, 橋本智代
    • Journal Title

      信州医学雑誌 59(2)

      Pages: 63-73

    • NAID

      130004551806

    • Related Report
      2010 Final Research Report
  • [Journal Article] Survival motor neuron(SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis2011

    • Author(s)
      Piao Y, Hashimoto T, Ovanagi K, et al.
    • Journal Title

      Brain Research

      Volume: 1327 Pages: 152-159

    • NAID

      120007110507

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 異常TDP-43蓄積と神経細胞死:筋萎縮性側索硬化症(ALS)と前頭側頭葉変性症(FTLD)における観察と考察2011

    • Author(s)
      小柳清光、橋本智代
    • Journal Title

      信州医誌

      Volume: 59 Pages: 63-73

    • NAID

      130004551806

    • Related Report
      2010 Annual Research Report
  • [Journal Article] グアム島の筋萎縮側索硬化症(ALS)-TDP-43と神経原線維変化から見るパーキンソン認知症、古典型ALS、前頭側頭葉変性症との異同-2010

    • Author(s)
      小柳清光, 橋本智代, 山奇峰雄
    • Journal Title

      最新医学 65(7)

      Pages: 1632-1641

    • Related Report
      2010 Final Research Report
  • [Journal Article] グアム島の筋萎縮性側索硬化症(ALS)-TDP-43と神経原線維変化から見るパーキンソン認知症、古典型ALS、前頭側頭葉変性症との異同-2010

    • Author(s)
      小柳清光、橋本智代、山崎峰雄
    • Journal Title

      最新医学

      Volume: 65 Pages: 1632-1641

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Magnesium concentration in the cerebrospinal fluid of mice and its response to changes in serum magnesium concentration2009

    • Author(s)
      Sun L, Kosugi Y, Kawakami E, Piao YS, Hashimoto T, Oyanagi K,
    • Journal Title

      Magnesium Research 22(4)

      Pages: 266-272

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel susceptible loci of Guam neurodegenerative disease : challenge of genome scans in genetic isolate2009

    • Author(s)
      Sieh W, Oyanagi K, et al.
    • Journal Title

      Human Molecular Genetics 18

      Pages: 3725-3738

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Degeneration of astrocytic processes and their mitochondria in cerebral cortical regions peripheral to the cortical infarction2009

    • Author(s)
      Ito U, Hakamata Y, Kawakami E, Oyanagi K
    • Journal Title

      Stroke 40

      Pages: 2173-2181

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel susceptible loci of Guam neurodegenerative disease : challenge of genome scans in genetic isolate2009

    • Author(s)
      Sieh Weiva
    • Journal Title

      Human Molecular Genetics 18

      Pages: 3725-3738

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophilic inclusion body disease and neuronal intermediate filament inclusion disease : a comparative clinicopathological study2008

    • Author(s)
      Yokota O, Tsuchiya K, Terada S, Ishizu H, Uchikado H, Ikeda M, Oyanagi K, et al.
    • Journal Title

      Acta Neuropathologica 115

      Pages: 561-575

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Familial amyotrophic lateral sclerosis with Gly93 Ser mutation in Cu/Zn superoxide dismutase : A clinical and neuropathological study2008

    • Author(s)
      Suzuki M, Irie T, Watanabe T, Oyanagi K, Ono S, et al.
    • Journal Title

      J Neurological Sciences 268

      Pages: 140-144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] グアム島パーキンソン認知症におけるFUS陽性構造物2010

    • Author(s)
      山崎峰雄, 橋本智代, 片山泰朗, 小柳清光
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京都,東京国際フォーラム
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] グアム島パーキンソン認知症におけるFUS陽性構造物2010

    • Author(s)
      山崎峰雄、橋本智代、小柳清光, ら
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京都、東京国際フォーラム
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] グアム島パーキンソン認知症におけるFUS陽性構造物2010

    • Author(s)
      山崎峰雄, 橋本智代, 片山泰朗, 小柳清光
    • Organizer
      第51回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京都,シェーンバッハ-サボー
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 人工呼吸器装着4年、全経過12年の多系統萎縮症(MSA-P)の1剖検例におけるalpha-synucleinの免疫組織学的検討2010

    • Author(s)
      渡辺武士, 入江東吾, 小柳清光, ら
    • Place of Presentation
      東京都,シェーンバッハ-サボー
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] グアム島パーキンソン認知症におけるFUS陽性構造物2010

    • Author(s)
      山崎峰雄、橋本智代、小柳清光, ら
    • Organizer
      第51回日本神経病理学会
    • Place of Presentation
      東京都、シェーンバッハ・サボー
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] リン酸化TDP43と神経原線維変化からみるグアム島の筋萎縮性側索硬化症(ALS)の本体について2009

    • Author(s)
      橋本智代, 小柳清光, ら
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      香川,サンポート高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] TDP-43と神経細胞脱落:グアム島パーキンソン認知症における観察2009

    • Author(s)
      小柳清光, 山崎峰雄, 橋本智代, 若林孝一, ら
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      香川県,サンポート高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 遠位部ほど明瞭な脊髄上下行路変性を呈した肺大細胞癌の71歳女性例2009

    • Author(s)
      小出隆司, 坂口隆, 小柳清光, ら
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      香川県,サンポート高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 人工呼吸器装着4年、全経過12年の多系統萎縮症(MSA-P)の1剖検例2009

    • Author(s)
      渡辺武士, 入江東吾, 小柳清光, ら
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      香川県,サンポート高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 若年性家族性ALS: 広汎型病変に好塩基性封入体を伴った1剖検例2009

    • Author(s)
      望月葉子, 橋本智代, 小柳清光, ら
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      香川県,サンポート高松
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] リン酸化TDP43と神経原線維変化からみるグアム島の筋萎縮性側索硬化症の本体について2009

    • Author(s)
      橋本智代
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      サンポート高松(香川県)
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] TDP-43と神経細胞脱落:グアム島のパーキンソン認知症における観察2009

    • Author(s)
      小柳清光
    • Organizer
      第50回日本神経病理学会総会学術研究会
    • Place of Presentation
      サンポート高松(香川県)
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 顆粒空胞変性はリン酸化TDP-43免疫染色陽性である2008

    • Author(s)
      小柳清光
    • Organizer
      第49回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Book] In : Magnesium in the Central Nervous System (Eds : Vink B, Nechifor M)(Magnesium in Parkinson's disease : an update in clinical and basic aspects.)2011

    • Author(s)
      Oyanagi K, Hashimoto T
    • Publisher
      University of Adelaide Press in press
    • Related Report
      2010 Final Research Report
  • [Book] Parkinsonism-dementia complex, In : Neurodegeneration : The molecular pathology of dementia and Movement disorder(Eds : Weller RO, Dickson DW)2011

    • Author(s)
      Oyanagi K., Hashimoto T.
    • Publisher
      Springer, Oxford in press
    • Related Report
      2010 Final Research Report
  • [Book] Magnesium in Parkinson's Disease: an update in clinical and basic aspects. In: Magnesium in the Central Nervous System (Eds: Vink B, Nechifor M)2011

    • Author(s)
      Oyanagi K, Hashimoto T.
    • Publisher
      University of Adelaide Press, Adelaide(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] Parkinsonism-dementia complex. In: Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Eds: Weller RO, Dickson DW)2011

    • Author(s)
      Ovanagi K, Hashimoto T, Yamazaki M.
    • Publisher
      Springer, Oxford(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] Neurodegeneration : The molecular pathology of dementia and movement disorders2009

    • Author(s)
      Kiyomitsu Oyanagi
    • Publisher
      The international society of neuropathology (ISN) neuropath press(In press)
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi