Nature of Guam-ALS and mechanism of degeneration of the motor neurons examined by the specific anti-phosphorylated TDP-43 antibody
| Project/Area Number | 20500330 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
HASHIMOTO Tomoyo Tokyo Metropolitan Organization for Medical Research, 医学部, 委嘱講師 (70425685)
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| Co-Investigator(Kenkyū-buntansha) |
OYANAGI Kiyomitsu 信州大学, 医学部, 教授 (00134958)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed(Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost : ¥3,500,000、Indirect Cost : ¥1,050,000)
Fiscal Year 2010 : ¥1,040,000 (Direct Cost : ¥800,000、Indirect Cost : ¥240,000)
Fiscal Year 2009 : ¥1,560,000 (Direct Cost : ¥1,200,000、Indirect Cost : ¥360,000)
Fiscal Year 2008 : ¥1,950,000 (Direct Cost : ¥1,500,000、Indirect Cost : ¥450,000)
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| Keywords | TDP-43 / 筋萎縮性側索硬化症 / パーキンソン認知症 / 神経変性疾患 |
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| Research Abstract |
To elucidate the nature of the amyotrophic lateral sclerosis (ALS) and the parkinsonism-dementia complex (PDC) of Guam, the authors examined the biochemical features of the TDP-43 (TAR-DNA binding protein-43 K dalton) and the progression pattern of the phosphorylated (p)-TDP-43 immunopositive inclusions in the brains and spinal cords of ALS, PDC and controls of Guam, and Japanese classic ALS, controls, and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). The results indicated that Guam ALS and PDC are basically different diseases, and Guam ALS occurs initially as classic ALS.
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Report
(4results)
Research Products
(31results)
