Neuronal activity-dependent regulation of ribosomal functions and synaptic plasticity
| Project/Area Number |
20500338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
YAMAMOTO Hideyuki University of the Ryukyus, 大学院・医学研究科, 教授 (60191433)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Noriko 国立大学法人琉球大学, 大学院・医学研究科, 教務職員 (40231584)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | カルモデュリン / 記憶 / シナプス可塑性 / 神経細胞 / リボソーム / リン酸化反応 / CaMキナーゼI / RPS19 / コルセミド / 細胞分裂 / 微小管 / タンパク質リン酸化反応 / PIM1キナーゼ / GT1-7細胞 / LTP |
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| Research Abstract |
Neuronal activity regulates synaptic functions. We considered that phosphorylation of a ribosomal protein (RPS19) might regulate the ribosomal functions. Our present results strongly suggest that CaM kinase I phosphorylates RPS19 and regulates the ribosomal formations in synapse in a neuronal activity-dependent manner.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II.2008
Author(s)
Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y.
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Journal Title
Biochem J 412
Pages: 223-231
Related Report
Peer Reviewed
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