Functional Analysis of a newly Neural stem/progenitor growth factor secreted from Dendritic cells

• Project/Area Number: 20500341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Keio University
• Principal Investigator: OHTA Shigeki Keio University, 医学部, 講師 (20365406)
• Co-Investigator(Kenkyū-buntansha): TODA Masahiro 慶應義塾大学, 医学部, 講師 (20217508)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経科学移植 / 再生医療 / 神経幹細胞 / 神経科学 / 移植・再生医療

Research Abstract

Macrophage migration inhibitory factor (MIF), which is secreted from dendritic cells, was identified as a new growth factor for neural stem/progenitor cells (NSPCs). MIF also could increase the self-renewal ability of NSPCs. In the present study, we identified molecules that support those functions. Furthermore, we clarified that MIF can control the cell migration of NSPCs. These findings will shed light on the therapeutic potential of MIF for the treatment of neural degenerative disorders through the endogenous NSPCs activation.

Research Products

• [Journal Article] Activation of dendritic-like cells and neural stem/progenitor cells in injured spinalcord by GM-CSF (2009)
  • Author(s): Hayashi K, Ohta S, Kawakami Y, Toda M
  • Journal Title: Neuroscience Res 64 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Isolation and characterization of dendritic cells from common marmosets for preclinical cell therapy studies. (2008)
  • Author(s): Ohta S, Ueda Y, Yaguchi M, Matsuzaki Y, Nakamura M, Toyama Y, Tanioka Y, Tamaoki N, Nomura T, Okano H, Kawakami Y, Toda M.
  • Journal Title: Immunology 373 Pages: 30-35
  • Peer Reviewed
• [Journal Article] Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL-12 administration. (2008)
  • Author(s): Yaguchi M, Ohta S, Toyama Y, Kawakami Y, Toda M.
  • Journal Title: J Neurosci Res 86 Pages: 1972-1980
  • Peer Reviewed
• [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells. (2010)
  • Author(s): Shigeki Ohta, Yutaka Kawakami, Hideyuki Okano, Masahiro Toda.
  • Organizer: Neuro2010
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-09-03
• [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells. (2010)
  • Author(s): Ohta S, Kawakami Y, Okano H, Toda M.
  • Organizer: The 16th international conference of the international society of differentiation.
  • Place of Presentation: Nara, Japan
• [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells. (2010)
  • Author(s): Ohta S, Kawakami Y, Okano H, Toda M.
  • Organizer: Neuro2010.
  • Place of Presentation: Kobe, Japan
• [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells. (2010)
  • Author(s): Shigeki Ohta, Yutaka Kawakami, Hideyuki Okano, Masahiro Toda.
  • Organizer: The 16th international conference of the international society of differentiation
  • Place of Presentation: Nara, Japan.
• [Presentation] Macrophage migration inhibitory factor(MIF)promotes proliferation and cell survival of neural stem/progenitor cells (2009)
  • Author(s): Ohta S, Kawakami Y, Okano H, Kawase T, Toda M.
  • Organizer: Neuro 2009(第32回日本神経科学会)
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] MIF Acts as a direct regulation of p53 in the nuclei of glioma cells and is a novel molecular target for the treatment of glioma cancer stem cells (2009)
  • Author(s): Fukaya R, Ohta S, Kawakami Y, Matsuzaki Y, Okano H, Kawase T, Toda M.
  • Organizer: International Society for Stem Cell Research, Annual Meeting
  • Place of Presentation: バルセロナ
  • Year and Date: 2009-07-09
• [Presentation] MIF Acts as a direct regulation of p53 in the nuclei of glioma cells and is a novel molecular target for the treatment of glioma cancer stem cells (2009)
  • Author(s): Fukaya R, Ohta S, Kawakami Y, Matsuzaki Y, Okano H, Kawase T, Toda M.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Macrophage migration inhibitory factor (MIF) promotes proliferation and cell survival of neural stem/progenitor cells (2009)
  • Author(s): Ohta S, Kawakami Y, Okano H, Toda M.
  • Organizer: Neuro2009
  • Place of Presentation: Nagoya, Japan
• [Presentation] MIF acts as a direct regulation of p53 in the nuclei of glioma cells and is a novel molecular target for the treatment of glioma cancer stem cells (2009)
  • Author(s): Fukaya R, Ohta S, Kawakami Y, Matsuzaki Y, Okano H, Kawase T, Toda M.
  • Organizer: 7th ISSCR.
  • Place of Presentation: Barcelona, Spain
• [Presentation] Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells following IL-12 administration (2008)
  • Author(s): Ohta S, Yaguchi M, Toyama Y, Kawakami Y, Toda M.
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington
  • Year and Date: 2008-11-18
• [Presentation] Cancer stem-like cells in side population of the glioblastoma cell line (2008)
  • Author(s): FUKAYA R, OHTA S, KAWAKAMI Y, KAWASE T, TODA M
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington
  • Year and Date: 2008-11-18
• [Presentation] Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells following IL-12 administration (2008)
  • Author(s): Ohta S, Yaguchi M, Toyama Y, Kawakami Y, Toda M.
  • Organizer: Neuro2008 (第31回日本神経科学会)
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10