Protein modification mechanism regulating synchronization/desynchronization of circadian system

• Project/Area Number: 20500344
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Toho University
• Principal Investigator: TAMARU Teruya Toho University, 医学部, 講師 (80291706)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 分子・細胞・神経生物学 / 細胞内情報伝達 / サーカディアンリズム / circadian rhythm / Phosphorylation / transcription factor / clock gene / signal transduction / casein kinase / bioluminescence / stress response / circadian clock / phosphorylation / protein kinase / live cell imagin / Casein kinase / SCN / Bioluminescence

Research Abstract

We elucidated circadian CK2-mediated BMAL1 (a core circadian transcription factor) phospholylation essential protein modification for circadian system.

Research Products

• [Journal Article] Role of periodic phosphorylation in mammalian circadian rhythm (2011)
  • Author(s): Tamaru T, Takamatsu K.
  • Journal Title: JOURNAL OF PHYSIOLOGICAL SCIENCES 61
• [Journal Article] Role of periodic phosphorylation in mammalian circadian rhythm (2011)
  • Author(s): Teruya Tamaru, Ken Takamatsu
  • Journal Title: The Journal of Physiological Sciences Volume: 61
• [Journal Article] Gating control of mammalian biological clock by circadian rhythmic kinase CK2. (2010)
  • Author(s): Tamaru T, Takamatsu K.
  • Journal Title: JOURNAL OF PHYSIOLOGICAL SCIENCES 60
• [Journal Article] CK2α phosphorylates BMAL1 to regulate the mammalian clock. (2009)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Nagai K, 他
  • Journal Title: Nat Struct Mol Biol 16 Pages: 446-448
  • Peer Reviewed
• [Journal Article] CLOCK : BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. (2009)
  • Author(s): Miyamura N, Hirayama J, Sawanobori K, Tamaru T, 他
  • Journal Title: Biol Pharm Bull 32 Pages: 1183-1187
  • Peer Reviewed
• [Journal Article] Circadian kinase CK2 phosphorylates BMAL1 to regulate the mammalian clock. (2009)
  • Author(s): Tamaru T, Takamatsu K.
  • Journal Title: NEUROSCIENCE RESEARCH 65
• [Journal Article] kinase CK2 rhythmically phosphorylates BMAL1 to regulate the mammalian system. (2009)
  • Author(s): Tamaru T, Takamatsu K. Multipotent
  • Journal Title: 日本分子生物学会年会講演要旨集 32 Pages: 168-168
• [Journal Article] Circadian rhythmic kinase CK2 phosphorylates BMAL1 to regulate the mammalian clock. (2009)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Takamatsu K.
  • Journal Title: JOURNAL OF PHYSIOLOGICAL SCIENCES 59 Pages: 282-286
• [Journal Article] CLOCK : BMAL-independent circadian oscillation of zebrafish Cryptochromela gene (2009)
  • Author(s): Miyamura N, Hirayama J, Sawanobori K, Tamaru T, Asaoka Y, Honda R, Yamamoto T, Uno H, Takamatsu K, Nishina H
  • Journal Title: Biol Pharm Bull 32 Pages: 1183-1187
  • Peer Reviewed
• [Journal Article] CK2α phosphorylates BMAL1 to regulate the mammalian clock. (2009)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Nagai K, Norioka S, Takamatsu K, Sassone-Corsi P.
  • Journal Title: Nature Structural & Molecular Biology 16 Pages: 446-448
  • Peer Reviewed
• [Journal Article] Circadian rhythmic kinase CK2α phosphorylates BMAL1 to regulate the mammalian clock. (2008)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Nagai K, 他
  • Journal Title: Nature Precedings
  • URL: http://precedings.nature.com/documents/1702/version/1/html
• [Journal Article] Circadian rhythmic kinase PFK phosphorylates BMAL1 to regulate the mammalian clock. (2008)
  • Author(s): Tamaru T, Takamatsu K.
  • Journal Title: NEUROSCIENCE RESEARCH 61
• [Journal Article] Circadian rhythmic CLOCK : BMAL1 kinase PFK controls mammalian clock function. (2008)
  • Author(s): Tamaru T, Takamatsu K.
  • Journal Title: JOURNAL OF PHYSIOLOGICAL SCIENCES 58
• [Journal Article] Circadian rhythmic kinase CK2α phosphorylates BMAL1 to regulate the mammalian clock. (2008)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Nagai K, Norioka S, Takamatsu K, Sassone-Corsi P.
  • Journal Title: Nature Precedings (http://precedings.nature.com/documents/1702/version/1)
• [Presentation] 概日リズム発現における周期性リン酸化シグナリングの役割 (2011)
  • Author(s): 田丸輝也,高松研
  • Organizer: 第88回日本生理学会大会(シンポジスト、オーガナイザー兼任)
  • Place of Presentation: 横浜(震災の為、誌上開催)
  • Year and Date: 2011-03-28
• [Presentation] 概日リズム発現における周期性リン酸化シグナリングの役割 (2011)
  • Author(s): 田丸輝也、高松研
  • Organizer: 第88回日本生理学会大会(シンポジスト、オーガナイザー兼任)
  • Place of Presentation: 横浜(東日本大震災の為、誌上開催)
  • Year and Date: 2011-03-28
• [Presentation] CK2による日周性リン酸化は哺乳類概日システムを統合制御する (2010)
  • Author(s): 田丸輝也,高松研
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] CK2による日周性リン酸化は哺乳類概日システムを統合制御する (2010)
  • Author(s): 田丸輝也、高松研
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-07
• [Presentation] 日周性BMAL1キナーゼCK2は哺乳類概日時計の必須レギュレータである (2010)
  • Author(s): 田丸輝也,高松研
  • Organizer: 第243回生理学東京談話会
  • Place of Presentation: 埼玉
  • Year and Date: 2010-12-04
• [Presentation] 日周性BMAL1キナーゼCK2は哺乳類概日時計の必須レギュレータである (2010)
  • Author(s): 田丸輝也、高松研
  • Organizer: 第243回生理学東京談話会
  • Place of Presentation: 埼玉医科大学(埼玉県)
  • Year and Date: 2010-12-04
• [Presentation] 多機能性キナーゼCK2はBMAL1を日周変動性にリン酸化する哺乳類概日システムの必須レギュレータである (2009)
  • Author(s): 田丸輝也,高松研
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-04
• [Presentation] 多機能性キナーゼCK2はBMAL1を日周変動性にリン酸化する哺乳類概日システムの必須レギュレータである (2009)
  • Author(s): 田丸輝也, 高松研
  • Organizer: 第31回日本分子生物学会例会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-04
• [Presentation] 概日変動性BMAL1キナーゼCK2は哺乳類体内時計の必須レギュレータである (2009)
  • Author(s): 田丸輝也,高松研
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] 概日変動性BMAL1キナーゼCK2は哺乳類体内時計の必須レギュレータである (2009)
  • Author(s): 田丸輝也, 高松研
  • Organizer: 第32回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Sassone-Corsi P : Circadian rhythmic kinase CK2 phosphorylates BMAL1 to regulate the mammalian clock. (2009)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Takamatsu K
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-29
• [Presentation] Circadian rhythmic kinase CK2 phosphorylates BMAL1 to regulate the mammalian clock (2009)
  • Author(s): Tamaru T, Hirayama J, Isojima Y, Takamatsu K, Sassone-Corsi P
  • Organizer: The 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Presentation] 日周期変動性BキナーゼPFKの哺乳類体内時計おける役割 (2008)
  • Author(s): 田丸輝也,高松研
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 日周期変動性BMAL1キナーゼPFKの哺乳類体内時計おける役割 (2008)
  • Author(s): 田丸輝也, 高松研
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Remarks] ホームページ等
  • URL: http://jglobal.jst.go.jp/detail.php?JGLOBAL_ID=200901071766454359&t=1&d=1&q=6000002824
• [Remarks]
  • URL: http://gyoseki.toho-u.ac.jp/thuhp/KgApp?kyoinId=ymidgdokggy
• [Remarks]
  • URL: http://gyoseki.toho-u.ac.jp/thuhp/KgApp?kyoinId=ymidgdokggy
• [Remarks]
  • URL: http://jglobal.jst.go.jp/detail.php?JGLOBAL_ID=200901071766454359&t=1&d=1&q=6000002824