Protective effects of molecular hydrogen on a stress-induced brain dysfunction

• Project/Area Number: 20500345
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nippon Medical School
• Principal Investigator: OHSAWA Ikuroh Nippon Medical School, 東京都健康長寿医療センター研究所, 研究副部長 (30343586)
• Co-Investigator(Renkei-kenkyūsha): OHTA Shigeo 日本医科大学, 医学研究科, 教授 (00125832) ; MIKAMI Toshio 日本医科大学, 医学部, 准教授 (60199966)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 精神 / 神経疾患の病態と治療 / モデル動物 / 酸化ストレス / 認知・記憶障害

Research Abstract

We investigated the effect of molecular hydrogen on a stress-induced brain dysfunction including cognitive and memory impairment, depression, and anxiety. We have recently reported that molecular hydrogen reduces oxidative stress and can penetrate the blood-brain barrier to protect neurons. Oxidative stress is widely accepted as a contributor to neuronal vulnerability and prevents hippocampal neurogenesis, which may be involved in cognitive function. The main results in this study have been published in Neuropsycopharmacology. Immobilization stress was given to mice 10 hours per day for 6 weeks. Water containing high concentration of hydrogen molecule (hydrogen water) was available ad libitum. We examined learning and memory ability using the passive avoidance test, novel recognition test and Morris water maze, and found that hydrogen water improved a stress-induced decline of cognitive function. Hydrogen water also restored the neurogenesis declined by restraint stress and reduced oxidative stress in the brain. Furthermore, we made depression-model mice with a combination of mild stress and did not find any effect of hydrogen water on this model, whereas hydrogen water restored a decline of neurogenesis. Precise molecular mechanisms concerning the effect of molecular hydrogen on neuronal cells is under investigation.

Research Products

• [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. (2011)
  • Author(s): Kamimura, N., Nishimaki, K., Ohsawa, I., Ohta, S.
  • Journal Title: Obesity. (in press)
  • Peer Reviewed
• [Journal Article] 水素分子医学の現状と展望 (2011)
  • Author(s): 大澤郁朗
  • Journal Title: 基礎老化研究 35 Pages: 1-7
  • NAID: 10027835646
  • Peer Reviewed
• [Journal Article] 水素分子医学の現状と展望 (2011)
  • Author(s): 大澤郁朗
  • Journal Title: 基礎老化研究 Volume: 35 Pages: 1-7
  • NAID: 10027835646
  • Peer Reviewed
• [Journal Article] Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice (2011)
  • Author(s): Kamimura, N.
  • Journal Title: Obesity Volume: In press
  • Peer Reviewed
• [Journal Article] Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function. (2010)
  • Author(s): Wu, I.-C., Ohsawa, I., Fuku, N., Tanaka, M.
  • Journal Title: Anal.N.Y.Academy Sci. 1201 Pages: 111-120
  • Peer Reviewed
• [Journal Article] Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. (2010)
  • Author(s): Wolf, AM., Asoh, S., Hiranuma, H., Ohsawa, I., Iio, K., Satou, A., Ishikura, M., Ohta, S.
  • Journal Title: J.Nutr. Biochem. 21 Pages: 381-389
  • Peer Reviewed
• [Journal Article] Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. (2010)
  • Author(s): Mitsuishi, T., Iwabu, Y., Tokunaga, K., Sata, T., Kaneko, T., Ohara, K., Ohsawa, I., Oda, F., Yamada, Y., Kawana, S., Ozaki, K., Nakatake, M., Yamada, O.
  • Journal Title: BMC Cancer. (in press)
  • Peer Reviewed
• [Journal Article] Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. (2010)
  • Author(s): Nakajima, S., Ohsawa, I., Ohta, S., Ohno, M., Mikami, T.
  • Journal Title: Behav. Brain Res. 211 Pages: 178-184
  • Peer Reviewed
• [Journal Article] Rapid Diffusion of Hydrogen Protects the Retina : Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury. (2010)
  • Author(s): Oharazawa, H., Igarashi, T., Yokota, T., Fujii, H., Suzuki, H., Machide, M., Takahashi, H., Ohta, S., Ohsawa, I.
  • Journal Title: Invest. Ophthalmol. Vis.Sci. 51 Pages: 487-492
  • Peer Reviewed
• [Journal Article] 酸化ストレス防御系の破綻とアルツハイマー型認知症 (2010)
  • Author(s): 大澤郁朗
  • Journal Title: 医学のあゆみ 232 Pages: 698-704
• [Journal Article] 酸化ストレス防御系の破綻とアルツハイマー型認知症 (2010)
  • Author(s): 大澤郁朗
  • Journal Title: 医学のあゆみ Volume: 232 Pages: 698-704
• [Journal Article] Rapid Diffusion of Hydrogen Protects the Retina : Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury (2010)
  • Author(s): Oharazawa, H.
  • Journal Title: Invest.Ophthalmol.Vis.Sci. Volume: 51 Pages: 487-492
  • Peer Reviewed
• [Journal Article] Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice (2010)
  • Author(s): Nakajima, S.
  • Journal Title: Behav.Brain Res. Volume: 211 Pages: 178-184
  • Peer Reviewed
• [Journal Article] Combined analysis of cell growth and apoptosis-regulating proteins in HPV sassociated anogenital tumors. (2010)
  • Author(s): Mitsuishi, T.
  • Journal Title: BMC Cancer Volume: In press
  • Peer Reviewed
• [Journal Article] Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. (2010)
  • Author(s): Wolf, AM.
  • Journal Title: J.Nutr.Biochem. Volume: 21 Pages: 381-389
  • Peer Reviewed
• [Journal Article] Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function. (2010)
  • Author(s): Wu, I-C.
  • Journal Title: Anal.N.Y.Academy Sci. Volume: 1201 Pages: 111-120
  • Peer Reviewed
• [Journal Article] Regular voluntary exercise cures stress-induced impairment of cognitive function and cell proliferation accompanied by increases in cerebral IGF-1 and GST activity in mice. (2010)
  • Author(s): Nakajima, S., et al.
  • Journal Title: Behav.Brain Res. (In press)
  • Peer Reviewed
• [Journal Article] Rapid Diffusion of Hydrogen Protects the Retina : Administration to the Eye of Hydrogen-Containing Saline in Retinal Ischemia-Reperfusion Injury. (2010)
  • Author(s): Oharazawa, H., et al.
  • Journal Title: Invest. Ophthalmol. Vis.Sci. 51 Pages: 487-492
  • Peer Reviewed
• [Journal Article] Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors (2010)
  • Author(s): Mitsuishi, T., et al.
  • Journal Title: BMC Cancer 10(In press)
  • Peer Reviewed
• [Journal Article] Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. (2010)
  • Author(s): Wolf, A.M., et al.
  • Journal Title: J.Nutr.Biochem. 21 Pages: 381-389
  • Peer Reviewed
• [Journal Article] Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. (2009)
  • Author(s): Endo, J., Sano, M., Katayama, T., Hishiki, T., Shinmura, K., Morizane, S., Matsuhashi, T., Katsumata, Y., Zhang, Y., Ito, H., Nagahata, Y., Marchitti, S., Nishimaki, K., Wolf, A.M., Nakanishi, H., Hattori, F., Vasiliou, V., Adachi, T., Ohsawa, I., Taguchi, R., Hirabayashi, Y., Ohta, S., Suematsu, M., Ogawa, S., Fukuda, K.
  • Journal Title: Circ Res. 105 Pages: 1118-1127
  • Peer Reviewed
• [Journal Article] Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. (2009)
  • Author(s): Nakashima, Y., Ohsawa, I., Konishi, F., Hasegawa, T., Kumamoto, S., Suzuki, Y., Ohta, S.
  • Journal Title: Neurosci Lett. 464 Pages: 193-198
  • Peer Reviewed
• [Journal Article] Are the effects of α-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? (2009)
  • Author(s): Suzuki, Y., Sano, M., Hayashida, K., Ohsawa, I., Ohta, S., Fukuda, K.
  • Journal Title: FEBS Lett. 583 Pages: 2157-2159
  • Peer Reviewed
• [Journal Article] Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory. (2009)
  • Author(s): Nakajima, S., Ohsawa, I., Nagata, K., Ohta, S., Ohno, M., Ijichi, T., Mikami, T.
  • Journal Title: Behav. Brain Res. 200 Pages: 15-21
  • Peer Reviewed
• [Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. (2009)
  • Author(s): Fu, Y., Ito, M., Fujita, Y., Ito, M., Ichihara, M., Masuda, A., Suzuki, Y., Maesawa, S., Kajita, Y., Hirayama, M., Ohsawa, I., Ohta, S., Ohno, K.
  • Journal Title: Neurosci. Lett. 453 Pages: 81-85
  • Peer Reviewed
• [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. (2009)
  • Author(s): Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., Ohta, S.
  • Journal Title: Neuropsycopharmacology 34 Pages: 501-508
  • Peer Reviewed
• [Journal Article] Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. (2009)
  • Author(s): Murakami, Y., Ohsawa, I., Kasahara, T., Ohta, S.
  • Journal Title: Neurobiol. Aging. 30 Pages: 325-329
  • Peer Reviewed
• [Journal Article] Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-γ1. (2009)
  • Author(s): Harita, Y., Kurihara, H., Kosako, H., Tezuka, T., Sekine, T., Igarashi, T., Ohsawa, I., Ohta, S., Hattori, S.
  • Journal Title: J. Biol. Chem. 284 Pages: 8951-8962
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. (2009)
  • Author(s): Nakashima-Kamimura, N., Mori, T., Ohsawa, I., Asoh, S., Ohta, S.
  • Journal Title: Cancer Chemother. Pharmacol. 64 Pages: 753-761
  • Peer Reviewed
• [Journal Article] Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. (2009)
  • Author(s): Endo, J., et al.
  • Journal Title: Circ.Res. 105 Pages: 1118-1127
  • Peer Reviewed
• [Journal Article] Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice. (2009)
  • Author(s): Nakashima, Y., et al.
  • Journal Title: Neurosci. Lett. 464 Pages: 193-198
  • Peer Reviewed
• [Journal Article] Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? (2009)
  • Author(s): Suzuki, Y., et al.
  • Journal Title: FEBS Lett. 583 Pages: 2157-2159
  • Peer Reviewed
• [Journal Article] Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory. (2009)
  • Author(s): Nakajima, S., et al.
  • Journal Title: Behav.Brain Res. 200 Pages: 15-21
  • Peer Reviewed
• [Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. (2009)
  • Author(s): Fu, Y., et al.
  • Journal Title: Neurosci. Lett. 453 Pages: 81-85
  • Peer Reviewed
• [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. (2009)
  • Author(s): Nagata, K., et al.
  • Journal Title: Neuropsycopharmacology 34 Pages: 501-508
  • Peer Reviewed
• [Journal Article] Cytoprotective role of mitochondrial amyloid β peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. (2009)
  • Author(s): Murakami, Y., et al.
  • Journal Title: Neurobiol. Aging 30 Pages: 325-329
  • Peer Reviewed
• [Journal Article] Phosphorylation of nephrin triggers Ca^<2+> signaling by recruitment and activation of phospholipase C-γ1. (2009)
  • Author(s): Harita, Y., et al.
  • Journal Title: J.Biol.Chem. 284 Pages: 8951-8962
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. (2009)
  • Author(s): Nakashima-Kamimura, N., et al.
  • Journal Title: Cancer Chemother. Pharmacol. 64 Pages: 753-761
  • Peer Reviewed
• [Journal Article] Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impainnent of spatial memory. (2009)
  • Author(s): Nakajima, S.
  • Journal Title: Behav. Brain Res. 200 Pages: 15-21
  • Peer Reviewed
• [Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. (2009)
  • Author(s): Fu, Y.
  • Journal Title: Neurosci. Lett. 453 Pages: 81-85
  • Peer Reviewed
• [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. (2009)
  • Author(s): Nagata, K.
  • Journal Title: Neuropsycopharmacology 34 Pages: 501-508
  • Peer Reviewed
• [Journal Article] Cytoprotective role of mitochondrial amyloid βpeptide-binding alcohol dehydrogenase against a cytotoxic aldehyde. (2009)
  • Author(s): Murakami, Y.
  • Journal Title: Neurobiol. Aging 30 Pages: 325-329
  • Peer Reviewed
• [Journal Article] Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. (2009)
  • Author(s): Wolf, A. M.
  • Journal Title: J. Nutr. Biochem. (In press)
  • Peer Reviewed
• [Journal Article] Phosphorylation of nephrin triggers Ca^<2+> signaling by recruitment and activation of phospholipase C-γ1. (2009)
  • Author(s): Harita, Y.
  • Journal Title: J. Biol. Chem. 284 Pages: 8951-8962
  • Peer Reviewed
• [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. (2009)
  • Author(s): Nakashima-Kamimura, N.
  • Journal Title: Cancer Chemother. Pharmacol. (In press)
  • Peer Reviewed
• [Journal Article] Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial ALDH2 activity. (2008)
  • Author(s): Ohsawa, I., Nishimaki, K., Murakami, Y., Suzuki, Y., Ishikawa, M., Ohta, S.
  • Journal Title: J. Neurosci. 28 Pages: 6239-6249
  • Peer Reviewed
• [Journal Article] Imaging mitochondrial redox environment and oxidative stress using a redox-sensitive fluorescent protein. (2008)
  • Author(s): Wolf, A.M., Asoh, S., Ohsawa, I., Ohta, S.
  • Journal Title: J.Nippon Med.Sch. 75 Pages: 66-67
  • NAID: 130004146942
  • Peer Reviewed
• [Journal Article] Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. (2008)
  • Author(s): Katsura, K.I., Takahashi, K., Asoh, S., Watanabe, M., Sakurazawa, M., Ohsawa, I., Mori, T., Igarashi, H., Ohkubo, S., Katayama, Y., Ohta, S.
  • Journal Title: J.Neurochem. 106 Pages: 258-270
  • Peer Reviewed
• [Journal Article] Involvement of mitoK(ATP) channel in protective mechanisms of cerebral ischemic tolerance. (2008)
  • Author(s): Watanabe, M., Katsura, K.I., Ohsawa, I., Mizukoshi, G., Takahashi, K., Asoh, S., Ohta, S., Katayama, Y.
  • Journal Title: Brain Res 1238 Pages: 199-207
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. (2008)
  • Author(s): Hayashida, K., Sano, M., Ohsawa, I., Shinmura, K., Tamaki, K., Kimura, K., Endo, J., Katayama, T., Kawamura, A., Kohsaka, S., Makino, S., Ohta, S., Ogawa, S., Fukuda, K.
  • Journal Title: Biochem. Biophys. Res.Commun. 373 Pages: 30-35
  • Peer Reviewed
• [Journal Article] Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem. (2008)
  • Author(s): Ohsawa, I., Nishimaki, K., Yamagata, K., Ishikawa, M., Ohta, S.
  • Journal Title: Biophys. Res. Commun. 377 Pages: 1195-1198
  • Peer Reviewed
• [Journal Article] Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. (2008)
  • Author(s): Kogiku, M., Ohsawa, I., Matsumoto, K., Sugisaki, Y., Takahashi, H., Teramoto, A., Ohta, S.
  • Journal Title: J.Clin.Neurosci. 15 Pages: 1198-1203
  • Peer Reviewed
• [Journal Article] 加齢 (2008)
  • Author(s): 大澤郁朗, 太田成男
  • Journal Title: 日本臨床66 増刊1 Pages: 169-174
• [Journal Article] ミトコンドリアに局在するAβ結合アルコール脱水素酵素による酸化ストレスからの防御機構 (2008)
  • Author(s): 村上弥生, 大澤郁朗, 太田成男
  • Journal Title: 日本臨床 66増刊1 Pages: 113-119
• [Journal Article] 水素分子による新しい概念の抗酸化治療法と予防医学 (2008)
  • Author(s): 太田成男, 大澤郁朗
  • Journal Title: 実験医学 26 Pages: 2074-2080
• [Journal Article] Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial ALDH2 activity. (2008)
  • Author(s): Ohsawa, I.
  • Journal Title: J. Neurosci. 28 Pages: 6239-6249
  • Peer Reviewed
• [Journal Article] Imaging mitochondrial redox environment and oxidative stress using a redox-sensitive fluorescent protein. (2008)
  • Author(s): Wolf, A. M.
  • Journal Title: J. Nippon Med. Sch. 75 Pages: 66-67
  • Peer Reviewed
• [Journal Article] Combination therapy with transductive anti-death FNK protein and FK506 ameliorates brain damage with focal transient ischemia in rat. (2008)
  • Author(s): Katsura, K. I.
  • Journal Title: J. Neurochem. 106 Pages: 258-270
  • Peer Reviewed
• [Journal Article] Involvement of mitoK (ATP) channel in protective mechanisms of cerebral ischemic tolerance. (2008)
  • Author(s): Watanabe, M.
  • Journal Title: Brain Res. 1238 Pages: 199-207
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. (2008)
  • Author(s): Hayashida, K.
  • Journal Title: Biochem. Biophys. Res. Commun. 373 Pages: 30-35
  • Peer Reviewed
• [Journal Article] Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. (2008)
  • Author(s): Ohsawa, I.
  • Journal Title: Biochem. Biophys. Res. Commun. 377 Pages: 1195-1198
  • Peer Reviewed
• [Journal Article] Prognosis of glioma patients by combined immunostaining for survivin, Ki-67 and epidermal growth factor receptor. (2008)
  • Author(s): Kogiku, M.
  • Journal Title: J. Clin. Neurosci. 15 Pages: 1198-1203
  • Peer Reviewed
• [Journal Article] 加齢 (2008)
  • Author(s): 大澤, 郁朗
  • Journal Title: アルツハイマー病-基礎研究から予防・治療の新しいパラダイム- 日本臨牀増刊 66増刊1 Pages: 169-174
• [Journal Article] ミトコンドリアに局在するAβ結合アルコール脱水素酵素による酸化ストレスからの防御機構 (2008)
  • Author(s): 村上, 弥生
  • Journal Title: アルツハイマー病一基礎研究から予防・治療の新しいパラダイムー 日本臨牀増刊 66増刊1 Pages: 113-119
• [Journal Article] 水素分子による新しい概念の抗酸化治療法と予防医学. (2008)
  • Author(s): 太田, 成男
  • Journal Title: 実験医学 26 Pages: 2074-2080
• [Presentation] 水素水による認知・記憶障害抑制効果のモデル動物を用いた検討 (2011)
  • Author(s): 大澤郁朗
  • Organizer: 分子状水素医学シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] 水素水による認知記憶障害抑制効果のモデル動物を用いた検討 (2011)
  • Author(s): 大澤郁朗
  • Organizer: 分子状水素医学シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memory tasks in AD model mice. (2010)
  • Author(s): 大澤郁朗
  • Organizer: International Conference on Alzheimer's Disease 2010 (ICAD2010).
  • Place of Presentation: ホノルル(米国)
• [Presentation] 水素分子は、肝臓グリコーゲン中に蓄積し、糖尿病モデルマウスの症状を改善する (2010)
  • Author(s): 上村尚美
  • Organizer: BMB2010
  • Place of Presentation: 神戸
• [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memory tasks in Alzheimer model mice. (2010)
  • Author(s): Nishimaki, K.
  • Organizer: 7^th ASMRM & 10^th J-mit.
  • Place of Presentation: 福岡
• [Presentation] Molecular hydrogen improves obesity and diabetes by inducing FGF21 through reducing oxidative stress in db/db mice. (2010)
  • Author(s): Kamimura, N.
  • Organizer: 7^th ASMRM & 10th J-mit.
  • Place of Presentation: 福岡
• [Presentation] Rapid diffusion of hydrogen molecule from hydrogen-containing eye drops reduces retinal ischemia-reperfusion injury. (2010)
  • Author(s): 大澤郁朗
  • Organizer: 7^th ASMRM & 10th J-mit.
  • Place of Presentation: 福岡
• [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memorv tasks in AD model mice (2010)
  • Author(s): Ohsawa, I.
  • Organizer: International Conference on Alzheimer's Disease 2010(ICAD2010)
  • Place of Presentation: Honolulu, USA
• [Presentation] 水素分子は肝臓グリコーゲン中に蓄積し糖尿病モデルマウスの症状を改善する (2010)
  • Author(s): 上村尚美
  • Organizer: BMB 2010
  • Place of Presentation: 神戸
• [Presentation] Consumption of hydrogen water prevents the age-dependent impairment in learning and memorv tasks in Alzheimer model mice. (2010)
  • Author(s): Nishimaki, K.
  • Organizer: 7^<th> ASMRM & 10^<th> J-mit
  • Place of Presentation: 福岡
• [Presentation] Molecular hydrogen improves obesity and diabetes by inducing FGF21 through reducing oxidative stress in db/db mice. (2010)
  • Author(s): Kamimura, N
  • Organizer: 7^<th> ASMRM & 10^<th> J-mit
  • Place of Presentation: 福岡
• [Presentation] Rapid diffusion of hydrogen molecule from hydrogen-containing eye drops reduces retinal ischemia-reperfusion injury. (2010)
  • Author(s): Ohsawa, I.
  • Organizer: 7^<th> ASMRM & 1O^<th> J-mit
  • Place of Presentation: 福岡
• [Presentation] 水素分子の還元力を利用した新しい医療 (2009)
  • Author(s): 大澤郁朗
  • Organizer: 第44回日本高気圧環境・潜水医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-01
• [Presentation] 水素分子の還元力を利用した新しい医療 (2009)
  • Author(s): 大澤郁朗
  • Organizer: 第44回日本高気圧環境・潜水医学会学術総会
  • Place of Presentation: 東京コンファレンスセンター(東京)
  • Year and Date: 2009-11-01
• [Presentation] (2008)
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-11
• [Presentation] 酸化ストレスを伴う認知・記憶障害の水素分子による抑制 (2008)
  • Author(s): 大澤, 郁朗
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 前橋
  • Year and Date: 2008-10-11
• [Presentation] Hydrogen acts as a therapeutic antioxidant in the brain ischemia and restores learning- and memory-deficits declined by physical restraint stress. (2008)
  • Author(s): 大澤郁朗
  • Organizer: International Conference on Alzheimer's Disease 2008 (ICAD2008).
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2008-07-28
• [Presentation] Hydrogen acts as a therapeutic antioxidant in the brain ischemia and restores learning- and memory-deficits declined by physical restraint stress. (2008)
  • Author(s): Ohsawa, I.
  • Organizer: International Conference on Alzheimer's Disease 2008 (ICAD2008)
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2008-07-28
• [Presentation] 酸化ストレスを伴う認知・記憶障害の水素分子による抑制
  • Author(s): 大澤郁朗
• [Remarks] ホームページ等
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/
• [Remarks]
  • URL: http://www.tmig.or.jp/J_TMIG/j_research/DA24.html
• [Remarks]
  • URL: http://www.nms.ac.jp/ig/H2/