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Instructive signals for learning in voluntary movement-their transmission pathway and representation in the brain

Research Project

Project/Area Number 20500353
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionUniversity of Tsukuba

Principal Investigator

IWAMOTO Yoshiki  University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (50184908)

Research Collaborator KAKU Yuki  植草学園大学, 保健医療学部, 助教 (50551363)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords運動学習 / 可塑性 / 上丘 / サル / 誤差情報 / エラー / サッケード適応 / 学習信号 / サッケード
Research Abstract

We learn from mistakes. Saccade adaptation, a simple form of learning in eye movement, provides a unique opportunity to investigate the neural mechanism of learning. Here we report that repetitive pairing of saccades with electrical stimulation of the brain produced robust adaptation and that the midbrain superior colliculus may be a source of neural signals that guide learning. This project has shown that instructive signals for motor learning can be artificially created, thus paving a way to developing a new approach to rehabilitation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (15 results)

  • [Journal Article] Saccade adaptation as a model of learning in voluntary movements.2010

    • Author(s)
      Iwamoto, Y., Kaku, Y.
    • Journal Title

      Exp.Brain Res. 204

      Pages: 145-162

    • Related Report
      2010 Final Research Report
  • [Journal Article] Saccade adaptation as a model of learning in voluntary movements.2010

    • Author(s)
      Yoshiki Iwamoto, Yuki Kaku
    • Journal Title

      Exp.Brain Res.

      Volume: 204 Pages: 145-162

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Learning signals from the superior colliculus for adaptation of saccadic eye movements in the monkey.2009

    • Author(s)
      Kaku, Y., Yoshida, K., Iwamoto, Y.
    • Journal Title

      J.Neurosci. 29

      Pages: 5266-5275

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of glycinergic inhibition in shaping activity of saccadic burst neurons2009

    • Author(s)
      Iwamoto, Y., Kaneko, H., Yoshida, K., Shimazu, H.
    • Journal Title

      J.Neurophysiol. 101

      Pages: 3063-3074

    • Related Report
      2010 Final Research Report
  • [Journal Article] Learning Signals from the Superior Colliculus for Adaptation of Saccadic Eye Movements in the Monkey2009

    • Author(s)
      Yuki Kaku, Kaoru Yoshida, Yoshiki Iwamoto
    • Journal Title

      Journal of Neuroscience 29

      Pages: 5266-5275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Learning Signals from the Superior Colliculus for Adaptation of Saccadic Eye Movements in the Monkey2009

    • Author(s)
      Yuki Kaku, Kaoru Yoshida, Yoshiki Iwamoto
    • Journal Title

      Journal of Neuroscience 29(in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Premotor inhibitory neurons carry signals related to saccade adaptation in the monkey.2008

    • Author(s)
      Kojima, Y., Iwamoto, Y., Robinson, F.R., Noto, C.T., Yoshida, K.
    • Journal Title

      J.Neurophysiol. 99

      Pages: 220-230

    • Related Report
      2010 Final Research Report
  • [Presentation] 視覚を支える眼球運動の脳内メカニズム2011

    • Author(s)
      岩本義輝
    • Organizer
      第10回茨城・栃木県活動分析研究大会
    • Place of Presentation
      茨城県稲敷郡阿見町
    • Year and Date
      2011-01-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of learning history on the course of saccade adaptation in the monkey.2010

    • Author(s)
      Haneda Y, Miura M, Yoshida K, Iwamoto Y
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spatial characteristics of saccade adaptation in the monkey.2010

    • Author(s)
      Ide M, Kaku Y, Yoshida K, Iwamoto Y
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Muller-Lyer illusion : misevaluation of length or location2010

    • Author(s)
      Tano T, Sasaki S, Iwamoto Y, Yoshida K
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of learning history on the course of saccade adaptation in the monkey.2010

    • Author(s)
      Haneda Y, Miura M, Yoshida K, Iwamoto Y
    • Organizer
      33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), P3-h08
    • Related Report
      2010 Final Research Report
  • [Presentation] Spatial characteristics of saccade adaptation in the monkey.2010

    • Author(s)
      Ide M, Kaku Y, Yoshida K, Iwamoto Y
    • Organizer
      33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), P3-h09
    • Related Report
      2010 Final Research Report
  • [Presentation] The Muller-Lyer illusion: misevaluation of length or location?2010

    • Author(s)
      Tano T, Sasaki S, Iwamoto Y, Yoshida K
    • Organizer
      33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), P3-h10
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes in saccade metrics associated with adaptation elicited by electrical stimulation of the superior colliculus.2009

    • Author(s)
      Yuki Kaku, Kaoru Yoshida, Yoshiki Iwamoto
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋(愛知)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Changes in saccade metrics associated with adaptation elicited by electrical stimulation of the superior colliculus.2009

    • Author(s)
      Kaku Y, Yoshida K, Iwamoto Y
    • Organizer
      32nd Annual Meeting of the Japan Neuroscience Society, P2-g23
    • Related Report
      2010 Final Research Report
  • [Presentation] Superior colliculus can play a teacher's role in saccade adaptation2008

    • Author(s)
      Kaku Y, Iwamoto Y, Yoshida K
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      Washlngton DC
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Driving signals for saccade adaptation from the superior colliculus.2008

    • Author(s)
      Iwamoto Y, Kaku Y, Yoshida K
    • Organizer
      Neural Mechanisms of Oculomotor and Vestibular Function (symposium).
    • Place of Presentation
      Medford, USA
    • Year and Date
      2008-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Driving signals for saccade adaptation from the superior colliculus.2008

    • Author(s)
      Yoshiki Iwamoto
    • Organizer
      International Symposium Neural Mechanisms of Oculomotor and Vestibular Function
    • Place of Presentation
      Medford, USA
    • Year and Date
      2008-10-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Signals from the superior colliculus act as a teacher for saccade adaptation.2008

    • Author(s)
      Yuki Kaku
    • Organizer
      Japan Neuroscience Society Symposium Voluntary Movement Control and the Cerebellum
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Superior colliculus can play a teacher's role in saccade adaptation.2008

    • Author(s)
      Kaku Y, Iwamoto Y, Yoshida K
    • Organizer
      Soc Neurosci Abstr 167.2
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Signals from the superior colliculus act as a teacher for saccade adaptation.2008

    • Author(s)
      Kaku Y, Iwamoto Y, Yoshida K
    • Organizer
      JNSS Symposium Voluntary Movement Control and the Cerebellum.
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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