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Regulation of the maturation of cerebellar synapses by PKN

Research Project

Project/Area Number 20500354
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionGunma University

Principal Investigator

YASUDA Hiroki  Gunma University, 大学院・医学系研究科, 准教授 (60294071)

Co-Investigator(Renkei-kenkyūsha) MUKAI Hideyuki  神戸大学, 大学院・医学研究科, 准教授 (80252758)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsKN1 / シナプス可塑性 / 長期抑圧 / 海馬 / 小脳 / 電気生理 / PKN1 / ヘテロシナプス性長期抑圧 / サイレントシナプス / ノックアウトマウス / PKN / シナプス長期抑圧
Research Abstract

I investigated the role of PKN1 in synaptic transmission and synaptic plasticity in the central nervous system electrophysiologically using PKN1a knockout (KO) mice. I found LTD was enhanced and heterosynaptic LTD was induced in the hippocampus of developing PKN1a KO mice and synaptic transmission was more immature. I concluded that PKN1 is promoting synaptic maturation by inhibiting LTD during development.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Book (2 results)

  • [Journal Article] Hypotonic Swelling-Induced Activation of Pkn1 Mediates Cell Survival in Cardiac Myocytes2010

    • Author(s)
      向井秀幸、小野功貴, 他
    • Journal Title

      Am J Physiol Heart Circ Physiol. Vol.300、No.1

      Pages: 191-200

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles2010

    • Author(s)
      向井秀幸、小野功貴, 他
    • Journal Title

      Neurosci Lett. Vol.471、No.1

      Pages: 20-24

    • NAID

      120003290064

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of an intracellularly acting inhibitory peptide selective for PKN.2009

    • Author(s)
      志賀一博、小野功貴、向井秀幸, 他
    • Journal Title

      Biochem J. Vol.425、No.2

      Pages: 445-543

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles2009

    • Author(s)
      小野功貴、向井秀幸, 他
    • Journal Title

      Neurosci.Lett. Vol.459、No.2

      Pages: 96-99

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice2008

    • Author(s)
      黄艶,安田浩樹,アブドルラハン・サリヒ、津本忠治、
    • Journal Title

      Journal of Neuroscience Vol.28、No.28

      Pages: 7074-7083

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus2008

    • Author(s)
      安田浩樹、黄艶、津本忠治
    • Journal Title

      Proceeding of the National Academy of Science of the United States of America Vol.105、No.8

      Pages: 3106-3111

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation2008

    • Author(s)
      吉川潮、向井秀幸, 他
    • Journal Title

      Oncogene Vol.27、No.17

      Pages: 2422-2429

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice.2008

    • Author(s)
      黄艶
    • Journal Title

      Journal of Neuroscience 28

      Pages: 7074-7083

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ドレブリンのアイソフォーム変換は海馬依存的学習とシナプス可塑性に必要である2011

    • Author(s)
      児島伸彦、安田浩樹, 他
    • Organizer
      第84回日本薬理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Neuron-specific drebrin isoform is necessary for hippocampus dependent learning in adulthood but not in young age of mice2010

    • Author(s)
      児島伸彦、安田浩樹, 他
    • Organizer
      Neuroscience 2010 Society for Neuroscience 40th Annual Meeting
    • Place of Presentation
      サンディエゴコンベンションセンター(サンディエゴ、米国)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Neuron-specific drebrin isoform is necessary for hippocampus-dependent learning in adulthood but not in young age of mice2010

    • Author(s)
      N.KOJIMA, H.YASUDA, et al
    • Organizer
      Neuroscience 2010 Society for Neuroscience 40^<th> Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] ドレブリンアイソフォーム変換不全マウスにおける海馬シナプス可塑性と海馬依存的学習の障害2010

    • Author(s)
      児島伸彦、安田浩樹, 他
    • Organizer
      Neuro2010 第33回日本神経科学学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] ドレブリンアイソフォーム変換不全マウスにおける海馬シナプス可塑性と海馬依存的学習の障害2010

    • Author(s)
      児島伸彦、安田浩樹, 等
    • Organizer
      Neuro2010第33回日本神経科学学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lrfn2/SALM1, a synaptic leucine-rich repeat transmembrane molecule is required for proper synapse maturation and brain function2009

    • Author(s)
      守村直子、安田浩樹, 他
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Synaptic maturation by PKN during development2009

    • Author(s)
      安田浩樹, 他
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Lrfn2/SALM1, a synaptic leucine-rich repeat transmembrane molecule is required for proper synapse maturation and brain function2009

    • Author(s)
      守村直子、太田摩耶、安田浩樹, 他
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synaptic maturation by PKN during development2009

    • Author(s)
      安田浩樹
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] SPECIFIC ROLE OF NEURONAL ISOFORM OF DREBRIN IN HIPPOCAMPAL SYNAPTIC PLASTICITY AND FEAR MEMORY2009

    • Author(s)
      児島伸彦、安田浩樹, 他
    • Organizer
      The XXXVI International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] SPECIFIC ROLE OF NEURONAL ISOFORM OF DREBRIN IN HIP POCAMPAL SYNAPTIC PLASTICITY AND FEAR MEMORY2009

    • Author(s)
      Kojima, Nobuhiko, Hiroki Yasuda, et al.
    • Organizer
      The XXXVI International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] LRR膜貫通分子Lrfn2/SALM1は海馬興奮性シナプスの形態や機能調節および可塑性に関与する2008

    • Author(s)
      守村直子、安田浩樹, 他
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2008-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] LRR膜貫通分子Lrfn2/SALM1は海馬興奮性シナプスの形態や機能調節および可塑性に関与する2008

    • Author(s)
      守村直子
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Book] Neuromethods : Protein Kinase Technologies2011

    • Author(s)
      H.Yasuda, H.Mukai
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] Neuromethods : Protein Kinase Technologies

    • Author(s)
      安田浩樹、向井秀幸
    • Publisher
      Springer(in press)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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