Regulation of the maturation of cerebellar synapses by PKN
| Project/Area Number |
20500354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Gunma University |
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Principal Investigator |
YASUDA Hiroki Gunma University, 大学院・医学系研究科, 准教授 (60294071)
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| Co-Investigator(Renkei-kenkyūsha) |
MUKAI Hideyuki 神戸大学, 大学院・医学研究科, 准教授 (80252758)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | KN1 / シナプス可塑性 / 長期抑圧 / 海馬 / 小脳 / 電気生理 / PKN1 / ヘテロシナプス性長期抑圧 / サイレントシナプス / ノックアウトマウス / PKN / シナプス長期抑圧 |
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| Research Abstract |
I investigated the role of PKN1 in synaptic transmission and synaptic plasticity in the central nervous system electrophysiologically using PKN1a knockout (KO) mice. I found LTD was enhanced and heterosynaptic LTD was induced in the hippocampus of developing PKN1a KO mice and synaptic transmission was more immature. I concluded that PKN1 is promoting synaptic maturation by inhibiting LTD during development.
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Report
(4 results)
Research Products
(23 results)
