Neural activity related to construction of compound images in the macaque prefrontal cortex

• Project/Area Number: 20500355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Niigata University
• Principal Investigator: HASEGAWA Isao Niigata University, 医歯学系, 教授 (60282620)
• Co-Investigator(Kenkyū-buntansha): TODA Haruo 新潟大学, 医歯学系, 講師 (10217507) ; IIJIMA Atsuhiko 新潟大学, 自然科学系, 助教 (00377186) ; KAWASAKI Keisuke 新潟大学, 医歯学系, 助教 (60511178)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 認知 / 記憶 / マカクザル / 前頭葉 / 電気生理 / 視覚 / 図形 / 大脳

Research Abstract

Japanese monkeys were trained in a symbolic construction matching-to-sample (SCMS) task in which 6 compound figures symbolically represent 6 objects. Behavioral experiments showed that the monkeys could learn the SCMS task, and generalize from item-object associations to category-object associations. We developed ultra-thin flexible electrode arrays for electrocorticogram (ECoG), and implanted them into the prefrontal cortex of the monkeys. During the SCMS task, ECoG responses to the second sample element was induced earlier and became larger than during sample presentation of a compound figure in a symbolic matching-to-sample task.

Research Products

• [Journal Article] Simultaneous recording of ECoG and intracortical neuronal activity using a flexible multichannel electrode-mesh in visual cortex (2011)
  • Author(s): Toda H, Suzuki T, Sawahata H, Majima K, Kamitani Y, Hasegawa I
  • Journal Title: Neuroimage 54 Pages: 203-212
  • Peer Reviewed
• [Journal Article] Simultaneous recording of ECoG and intracortical neuronal activity using a flexible multichannel electrode-mesh in visual cortex. (2011)
  • Author(s): Toda H, Suzuki T, Sawahata H, Majima K, Kamitani Y, Hasegawa I.
  • Journal Title: Neuroimage Volume: 54 Pages: 203-212
  • Peer Reviewed
• [Journal Article] 前脳のGABA受容体による自律機能の調節 (2010)
  • Author(s): 山口賢一、山田貴穗、濱齊、渡辺賢一、長谷川功
  • Journal Title: 新潟医学会雑誌 (In press)
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 長谷川功(編集:伊藤正男・川合述史)
  • Journal Title: ブレインサイエンス・レビュー2010(プレインサイエンス振興財団株式会社クバプロ) Pages: 209-222
• [Journal Article] 前脳GABA(A)受容体とバゾプレッシン分泌 (2009)
  • Author(s): 山口賢一、山田貴穂、長谷川功
  • Journal Title: 生体の科学 60 Pages: 378-379
  • Peer Reviewed
• [Journal Article] 前脳GABA(A)受容体とバゾプレッシン分泌 (2009)
  • Author(s): 山口賢一、山田貴穗、長谷川功
  • Journal Title: 生体の科学60 5 Pages: 378-379
  • Peer Reviewed
• [Journal Article] 記憶を貯める脳、活かす脳 (2008)
  • Author(s): 長谷川功
  • Journal Title: 新潟医学会雑誌 122 Pages: 663-668
  • Peer Reviewed
• [Journal Article] 認知記憶の脳内表現とその活性化 (2008)
  • Author(s): 長谷川功、飯島淳彦、戸田春男
  • Journal Title: 新潟県医師会報 696 Pages: 1-5
  • Peer Reviewed
• [Journal Article] 記憶を貯める脳、活かす脳 (2008)
  • Author(s): 長谷川 功
  • Journal Title: 新潟医学会雑誌 122 Pages: 663-668
  • Peer Reviewed
• [Journal Article] 認知記憶の脳内表現とその活性化 (2008)
  • Author(s): 長谷川功, 飯島淳彦, 戸田春男
  • Journal Title: 新潟県医師会報 696 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols.
  • Author(s): Matsuo T, Kawasaki K, Osada T, Sawahata H, Suzuki T, Shibata M, Miyakawa N, Nakahara K, Iijima A,, Sato N, Kawai K, Saito N, Hasegawa I
  • Journal Title: Frontiers in Systems Neuroscience in press
  • Peer Reviewed
• [Journal Article] 前脳のGABA 受容体による自律機能の調節
  • Author(s): 山口賢一、山田貴穂、濱齊、渡辺賢一、長谷川功
  • Journal Title: 新潟医学会雑誌 in press
• [Journal Article] 前脳のGABA受容体による自律機能の調節
  • Author(s): 山口賢一、山田貴穂、濱齊、渡辺賢一、長谷川功
  • Journal Title: 新潟医学会雑誌 Volume: In press
• [Presentation] Symmetry and generalization in visual-visual association learning in macaque monkeys (2010)
  • Author(s): Iijima A, Kawasaki K, Hatano Y, Fujisawa N, Hasegawa I.
  • Organizer: Soc Neurosci Abstr 36
  • Place of Presentation: San Diego USA(in press)
  • Year and Date: 2010-11-17
• [Presentation] Symmetry and generalization in visual visual association learning in macaque monkeys (2010)
  • Author(s): Iijima A, Kawasaki K, Hatano Y Fujisawa N, Hasegawa I
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-17
• [Presentation] Electrocorticography within the superior temporal sulcus of macaques (2010)
  • Author(s): Matsuo T, Kawasaki K, Sawahata H, Shibata M, Miyakawa N, Kawai K, Satou N, Saito N, Nakahara K,Suzuki T, Hasegawa I.
  • Organizer: Soc Neurosci Abstr 36,123,
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-16
• [Presentation] Electrocorticography within the superior temporal sulcus of macaques (2010)
  • Author(s): Matsuo T, Kawasaki K, Sawahato H, Shibata M, Miyakawa N, Kawai K, Satou N, Saito N, Nakahara K, Suzuki T, Hasegawa I.
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-16
• [Presentation] Neural decoding of visual object categories using temporal patterns of ECoG signals (2010)
  • Author(s): Majima K, Matsuo T, KawasakiK, Kawai K, Masuda H, KuniiN, Murakami H, Kamada K, Kameyama S, Saito N, HasegawaI, Kamitani Y
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-16
• [Presentation] Improvement of a flexible Parylene ECoG electrode for long-term stable recording (2010)
  • Author(s): Suzuki T, Kotake N, FukayamaO, Takeuchi S, Watanabe H, IsaT, Sawahata H, Toda H, Hasegawa I, Mabuchi K.
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-11-13
• [Presentation] 視覚刺激に対する瞳孔径・瞳孔反応とストレス評価 (2010)
  • Author(s): 飯島淳彦、小杉剛、木竜徹、長谷川功、板東武彦
  • Organizer: 第25回生体・生理工学シンポジウム
  • Place of Presentation: 岡山
  • Year and Date: 2010-09-23
• [Presentation] Neural decoding of visual oblect categories using temporal pattems of ECoG signals (2010)
  • Author(s): Majima K, Matsuo T, Kawasaki K, Kawai K, Masuda H, KuniiN, Murakami H, Kamada K, Kameyama S, Saito N, HasegawaI, Kamitani Y.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] An evaluation of recording qualities of MEMS-based mesh ECoG electrode (2010)
  • Author(s): Sawahata H, Suzuki T, KotakeN, Majima K, Kamitani Y, TodaH, Hasegawa I
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Electrocorticographic mapping of human ventral visual areas (2010)
  • Author(s): Matsuo T, Kawasaki T, Kawai K, Masuda H, Kunii N, Murakami H, Majima K, Kamada K, Kamitani Y, Kameyama K, SaitoN, Hasegawa I.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Regression of forearm reach and grasp movement trajectories using intracortical local field (2010)
  • Author(s): Watanabe H, Sakatani T, Togawa T, Yoshida M, Toda H, Sawahata H, Isa T, Hasegawa I, Suzuki T, Yamashita M, Sato M, Kawato M.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Symbolization of object categories by macaque monkeys (2010)
  • Author(s): Iijima A, Hatano Y, Fujisawa N, Hasegawa I.
  • Organizer: Neurosci Res 68 suppl,e180,2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Symbolization of object categories by macaque monkeys (2010)
  • Author(s): Iijima A, Hatano Y, Fujisawa N, Hasegawa I.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Gene transfer into the primate central nervous system via antero-and retrograde infections by adeno-associated viruses (2010)
  • Author(s): Masamizu Y, Okada N, Kawasaki K, Ishibashi H, Takeda S, Yuasa S, Hasegawa I, Nakahara K.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] The basis of the EcoG signal in visual cortex (2010)
  • Author(s): Hasegawa I
  • Organizer: 2nd UK-Japan Workshop on the Brain-Machine Interface
  • Place of Presentation: Newcastle, UK
  • Year and Date: 2010-02-26
• [Presentation] The basis of the EcoG signal in visual cortex (2010)
  • Author(s): Hasegawa I.
  • Organizer: 2^<nd> UK-Japan Workshop on the Brain-Machine Interface
  • Place of Presentation: Newcastle, UK
  • Year and Date: 2010-02-26
• [Presentation] Simultaneous recording of high density electrocorticogram and intracortical activity using MEMS-fabricated electrode array (2010)
  • Author(s): Toda H, Sawahata H, Suzuki T, Majilna K, Kamitani Y, HasegawaI.
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
• [Presentation] Simultaneous recording of visual cortical response by a meshelectrode array and an intracortical microelectrode (2009)
  • Author(s): Toda H, Sawahata H, Suzuki T, Watanabe H, Isa T, Hasegawa I.
  • Organizer: Society for Neuroscience Abstr
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-21
• [Presentation] 映像の動き成分が脳血流に与える影響 (2009)
  • Author(s): 飯島淳彦, 鵜飼一彦, 木竜徹, 長谷川功, 板東武彦
  • Organizer: 第24回生体生理工学シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-26
• [Presentation] Mesh electrode arrays applied to record visual cortical activities in hooded rats (2009)
  • Author(s): Sawahata H, Toda H., Suzuki T., Hasegawa I.
  • Organizer: Neurosci Res第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] 大脳視覚イメージの活性化と解読 (2009)
  • Author(s): 長谷川功
  • Organizer: 第29回関東機能的脳外科カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2009-09-05
• [Presentation] イメージを浮かべる脳、覚える脳 (2009)
  • Author(s): 長谷川功
  • Organizer: 第25回真鶴セミナー(生涯教育認定事業NO.12728)
  • Place of Presentation: 厚木
  • Year and Date: 2009-08-29
• [Presentation] Pupillary light reflexes to color stimuli in rats using a newly developed video pupilometer with a diffuse illumination system (2009)
  • Author(s): Iijima A.Haida M.Iida S.Sonoda S, Hasegawa I
  • Organizer: IUPS2009
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] 前脳のGABA受容体による自律機能の調節 (2009)
  • Author(s): 山口賢一、山田貴穗、濱齊、渡辺賢一、長谷川功
  • Organizer: 第47回新潟高血圧談話会
  • Place of Presentation: 新潟
  • Year and Date: 2009-07-10
• [Presentation] 映像酔いによる脳血流変化と心理スコアの関係 (2009)
  • Author(s): 飯島淳彦, 木竜徹, 鵜飼一彦, 長谷川功, 板東武彦
  • Organizer: 第48回日本生体医工学会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Presentation] Simultaneous recording of visual cortical response by a meshelectrode array and an intracortical microelectrode (2009)
  • Author(s): Toda H, Sawahata H, Suzuki T, Watanabe H, Isa T, Hasegawa I.
  • Organizer: Soc Neurosci Abstr 35,770.20
  • Place of Presentation: Chicago,USA
• [Presentation] Pupillary and vergence responses to the cognition of radial optic flow., Pupil Informatics: Pupil Response Mechanisms (2008)
  • Author(s): Iijima A., Ukai K., Tsujimura S., Torii M., Hi ramoto S., Hasegawa I., Bando T
  • Organizer: Visual Performance and Clinical Applications
  • Place of Presentation: London, UK
• [Book] 局所フィールド電位の全脳同時記録(ブレインサイエンス・レビュー2010(編集))(ブレインサイエンス振興財団)(伊藤正男・川合述史) (2010)
  • Author(s): 長谷川功
  • Publisher: (株)クバプロ
• [Book] ブレインサイエンス・レビュー2010 (2010)
  • Author(s): 長谷川功
  • Publisher: (株)クバプロ
• [Patent(Industrial Property Rights)] 網状生体電極アレイ (2010)
  • Inventor(s): 長谷川功(寄与率60%)、鈴木隆文(同40%)
  • Industrial Property Rights Holder: 新潟大学1東京大学
  • Filing Date: 2010-07-30
• [Patent(Industrial Property Rights)] 意志伝達支援装置 (2009)
  • Inventor(s): 長谷川功(寄与率70%)、神谷之康(同30%)
  • Industrial Property Rights Holder: 新潟大学/ATR
  • Filing Date: 2009-04-27
• [Patent(Industrial Property Rights)] 網状生体電極アレイ (2009)
  • Inventor(s): 長谷川功(寄与率60%)、鈴木隆文(同40%)
  • Industrial Property Rights Holder: 新潟大学/東京大学
  • Filing Date: 2009-07-30
• [Patent(Industrial Property Rights)] 意志伝達支援装置 (2009)
  • Inventor(s): 長谷川功(寄与率70%)、神谷之康(同30%)
  • Industrial Property Rights Holder: 新潟大学ATR
  • Filing Date: 2009-04-27
• [Patent(Industrial Property Rights)] 網状生体電極アレイ (2009)
  • Inventor(s): 長谷川功(寄与率60%)、鈴木隆文(同40%)
  • Industrial Property Rights Holder: 新潟大学東京大学
  • Filing Date: 2009-07-30