| Project/Area Number |
20500357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
|
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| Research Institution | Kanazawa University |
|---|
Principal Investigator |
SHOSAKU Takako Kanazawa University, 保健学系, 教授 (60179025)
|
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| Research Collaborator |
ECHIGO Ryousuke 金沢大学, 大学院・医学系研究科保健学専攻, 博士後期課程2年
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ニューロン・シナプス・神経回路 / シナプス可塑性 / 生理学 / 神経科学 / 脳・神経 / シグナル伝達 / カンナビノイド |
|---|
| Research Abstract |
In the present study, we investigated the conditions inducing long-lasting endocannabinoid release, which is required for endocannabinoid-mediated long-term depression. We demonstrated that protease-activated receptor-1 (PAR1), which can be activated persistently by proteases, can induce endocannabinoid release when activated. We observed that the activation of group 1 metabotropic glutamate receptors or M_1/M_3 muscarinic receptors occasionally induced long-lasting endocannabinid release, which could not be attributed to long-lasting enhancement of PLCβ.
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