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Analysis of synaptic connection specific plasticity following whisker deprivation using laser photostimulation.

Research Project

Project/Area Number 20500358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionOsaka University

Principal Investigator

KIMURA Fumitaka  大阪大学, 大学院・医学系研究科, 准教授 (00202044)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsニューロン / シナプス / 神経回路 / 可塑性 / 学習 / 記憶 / 大脳皮質 / 体性感覚野 / バレル皮質 / スパイクタイミング依存性可塑性 / 抑制性細胞 / 臨界期 / 視床皮質投射 / 4層-2/3層結合 / 生後第2週 / スパイクタイミング依存性 / 視床-皮質投射 / 4層-2 / 3層 結合 / マルチ電極記録
Research Abstract

In the somatosensory barrel cortex of mice, we found that thalamic latency to GABAergic neurons are shorter than that to excitatory neurons in layer 4, by about 0. 8 ms. This latency difference enables very fast inhibition in L4 and L2/ 3 neurons, which plays a critical role in generation of spike sequences of" L4 followed by L2/ 3" in response to whisker stimulation. We also found that such latency difference was created after P12-14, simultaneously with the initiation of critical period. We indicated that such latency difference was resulted from differed thickness of axons projecting those target neurons.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development2010

    • Author(s)
      Akaneya, Y., Souya, K., Kitamura, A., Kimura, F., Washburn, C., Zhou, R., Ninan, I., Tsumoto, T., and Ziff, E.
    • Journal Title

      PLoS One

      Volume: 5(8)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex2010

    • Author(s)
      Kimura, F., Itami, C., Ikezoe, K., Tamura, H., Fujita, I., Yanagawa, Y., Obata, K. and Ohshima, M.
    • Journal Title

      Journal of Physiology

      Volume: 588 Pages: 2769-2787

    • Related Report
      2010 Annual Research Report 2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development2010

    • Author(s)
      Akaneya, et al
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myelination and Isochronicity in neural networks2009

    • Author(s)
      Kimura, F. and Itami, C.
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 3 Pages: 12-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myelination and isochronicity in the neural networks2009

    • Author(s)
      Kimura F., Itami C.
    • Journal Title

      Frontiers in Neuroanatomy

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Developmental switch in the spike timing-dependent plasticity underlying the initiation of map plasticity2011

    • Author(s)
      Itami, C. and Kimura, F
    • Organizer
      41st Annual Meeting for the Society for Neuroscience Washington D. C
    • Place of Presentation
      USA
    • Year and Date
      2011-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 発達期バレル皮質2/ 3層錐体細胞への2つの異なるスパイクタイミング依存性可塑性の集束2011

    • Author(s)
      木村文隆、伊丹千晶
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Developmental switch in the spike timing dependent plasticity at layer 4 to layer 2/ 3 synapses in coincidence with the initiation of critical period in the mouse barrel cortex2011

    • Author(s)
      Kimura, F. and Itami, C.
    • Organizer
      8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Italy
    • Year and Date
      2011-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of bilateral spike timing dependent plasticity specifically appeared during the 2nd postnatal week at L4-L2/ 3 synapses in the mouse barrel cortex2010

    • Author(s)
      Itami, C. and Kimura, F
    • Organizer
      40th Annual Meeting for the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of bilateral spike timing dependent plasticity specifically appeared during the 2nd postnatal week at L4-L2/3 synapses in the mouse barrel cortex2010

    • Author(s)
      Itami, C
    • Organizer
      40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of STDP at L4-L2/3 and its development in the barrel cortex2010

    • Author(s)
      木村文隆
    • Organizer
      第33回日本神経科学学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] バレル皮質4層-2/ 3層のスパイクタイミング依存性可塑性と発達に伴う変化2010

    • Author(s)
      木村文隆、伊丹千晶
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 4-2/ 3層間シナプスのフィードフォーワード抑制による発火タイミング制御の発達とそれに伴うSTDPの変化2010

    • Author(s)
      木村文隆、伊丹千晶
    • Organizer
      第87回生理学会大会シンポジウム
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Developmental switch in the spike timing dependent plasticity at L4-L2/3 synapse in parallel with feedforward inhibition in the barrel cortex2010

    • Author(s)
      木村文隆
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡(招待講演)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Yanagawa Activation of a2A adrenoceptors suppresses excitatory synaptic transmission to layer 4 cells both from thalamic and intracortical sources in the mouse barrel cortex through presynaptic mechanism2009

    • Author(s)
      F. Kimura, M. Ohshima, C. Itami, Y.
    • Organizer
      39th Annual Meeting for the Society for Neuroscience
    • Place of Presentation
      USA
    • Year and Date
      2009-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Developmental switch in the spike-timing-dependent plasticity between L4-L2/3 synapse in parallel with feedforward inhibition in mouse barrel cortex2009

    • Author(s)
      Itami, C.
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activation of a2A adrenoceptors suppresses excitatory transmission to layer 4 cells both from thalamic and Intracortical sources in the mouse barrel cortex through presynaptic mechanism2009

    • Author(s)
      Kimura, F.
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Developmental switch in the spike timing-dependent plasticity between L4-L2/ 3 synapse in parallel with feedforward inhibition in mouse barrel cortex2009

    • Author(s)
      C. Itami, S-I. Watanabe, F. Kimura
    • Organizer
      39th Annual Meeting for the Society for Neuroscience
    • Place of Presentation
      USA
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] フィードフォーワード抑制による発火タイミング制御の発達とそれに伴う可塑性の変化2009

    • Author(s)
      木村文隆、伊丹千晶
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Maturation of precise temporal control of spike timing by feedforward inhibition and associated developmental switch in the L4-L2/3 plasticity in the barrel cortex2009

    • Author(s)
      木村文隆
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] バレル皮質4層細胞への興奮性伝達に対するα2Aノルアドレナリン受容体によるシナプス前性抑制2009

    • Author(s)
      大島稔、伊丹千晶、小幡邦彦、柳川右千夫、木村文隆
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Activation of α 2A adrenoceptors suppresses excitatory synaptic transmission to layer 4 cells in the mouse barrel cortex through presynaptic mechanism2009

    • Author(s)
      大島稔
    • Organizer
      第32回日本神経科学学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of noisecorrelation in rat barrel columns2008

    • Author(s)
      Ikezoe, K
    • Organizer
      38^<th> Annual Meeting of Society for Neuroselence
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスバレル皮質4層細胞への視床及び皮質細胞からの人力に対するノルアドレナリンの制御2008

    • Author(s)
      大島稔
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット感覚野ニューロン群におけるノイズ相関の生後発達2008

    • Author(s)
      池添貢司、田村弘、木村文隆、藤田一郎
    • Organizer
      第31回日本神経科学学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット感覚野ニューロン群におけるノイズ相関の生後発達2008

    • Author(s)
      池添貢司
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/molneu/member_kf.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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