Analysis of synaptic connection specific plasticity following whisker deprivation using laser photostimulation.
Project/Area Number |
20500358
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurophysiology and muscle physiology
|
Research Institution | Osaka University |
Principal Investigator |
KIMURA Fumitaka 大阪大学, 大学院・医学系研究科, 准教授 (00202044)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ニューロン / シナプス / 神経回路 / 可塑性 / 学習 / 記憶 / 大脳皮質 / 体性感覚野 / バレル皮質 / スパイクタイミング依存性可塑性 / 抑制性細胞 / 臨界期 / 視床皮質投射 / 4層-2/3層結合 / 生後第2週 / スパイクタイミング依存性 / 視床-皮質投射 / 4層-2 / 3層 結合 / マルチ電極記録 |
Research Abstract |
In the somatosensory barrel cortex of mice, we found that thalamic latency to GABAergic neurons are shorter than that to excitatory neurons in layer 4, by about 0. 8 ms. This latency difference enables very fast inhibition in L4 and L2/ 3 neurons, which plays a critical role in generation of spike sequences of" L4 followed by L2/ 3" in response to whisker stimulation. We also found that such latency difference was created after P12-14, simultaneously with the initiation of critical period. We indicated that such latency difference was resulted from differed thickness of axons projecting those target neurons.
|
Report
(4 results)
Research Products
(27 results)
-
[Journal Article] Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development2010
Author(s)
Akaneya, Y., Souya, K., Kitamura, A., Kimura, F., Washburn, C., Zhou, R., Ninan, I., Tsumoto, T., and Ziff, E.
-
Journal Title
Related Report
Peer Reviewed
-
[Journal Article] Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex2010
Author(s)
Kimura, F., Itami, C., Ikezoe, K., Tamura, H., Fujita, I., Yanagawa, Y., Obata, K. and Ohshima, M.
-
Journal Title
Journal of Physiology
Volume: 588
Pages: 2769-2787
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-