| Project/Area Number |
20500360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | Hyogo College of Medicine |
|---|
Principal Investigator |
OKU Yoshitaka Hyogo College of Medicine, 医学部, 教授 (20252512)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKADA Yasumasa 慶應義塾大学, 医学部, 准教授 (80160688)
KOGANEZAWA Tadachika 筑波大学, 人間総合科学研究科, 助教 (80431691)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 呼吸リズム / 呼吸ニューロンネットワーク / ペースメーカー / in situ標本 / 膜電位イメージング |
|---|
| Research Abstract |
A μ-opioid DAMGO slows down the respiratory rhythm in neonatal rats in vitro. However, we found that DAMGO applied to the perfusate of the arterially perfused in situ preparation consistently induces rapid breathing with remarkable reduction of expiratory time. The vagal post-inspiratory activity was obliterated. These results indicate that DAMGO switches the breathing pattern from 3-phase to 2-phase in juvenile rats, which is different from the response of neonates.
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