Electrophysiological characterization of locomotor-related inhibitory neurons in the spinal cord
| Project/Area Number |
20500365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NISHIMARU Hiroshi University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (20302408)
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOSUE Kazuyuki 産業技術総合研究所, 脳神経情報部門, 主任研究員 (50356903)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ニューロン / シナプス / 神経回路 / 神経科学 / 生理学 / 脊髄 / 歩行 |
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| Research Abstract |
In the mammalian spinal cord, Renshaw cells (RCs) are excited by axon collaterals of motoneurons, and in turn provide recurrent inhibition of MNs. However, a large part of the synaptic modulation of RCs during motor behaviors such as locomotion remains unclear. In this study, synaptic inputs to RCs in the lumbar segment during motor activity were examined. These results indicate that RCs are strongly inhibited by the spinal network during movements and the strength of the inhibition is related to the magnitude of the motor activity.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] The physiological roles of vesicular GABA transporter during embryonic development : a study using knockout mice.2010
Author(s)
Saito K, Kakizaki T, Hayashi R, Nishimaru H, Furukawa T, Nakazato Y, Takamori S, Ebihara S, Uematsu M, Mishina M, Miyazaki J, Yokoyama M, Konishi S, Inoue K, Fukuda A, Fukumoto M, Nakamura K, Obata K, Yanagawa Y.
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Journal Title
Molecular Brain 3
Pages: 40-40
NAID
Related Report
Peer Reviewed
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