A study of shambling mice with a Caspr mutation ; as a model for the neurodegenerative disease
Project/Area Number |
20500370
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Nagoya University |
Principal Investigator |
TAKAGISHI Yoshiko Nagoya University, 環境医学研究所, 助教 (50024659)
|
Co-Investigator(Kenkyū-buntansha) |
ODA Senーichi 岡山理科大学, 理学部, 教授 (60023660)
HAYASHI Yoshitaka 名古屋大学, 環境医学研究所, 准教授 (80420363)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 疾患モデル / 有髄神経線維 / ミエリン / 軸索 / 突然変異マウス / 髄神経線維 / ランビエ絞輪 / パラノード / 免疫組織化学 / 電子顕微鏡学 |
Research Abstract |
The shambling (shm) mouse with mutation of a Caspr gene exhibits ataxia and hind limb paresis at 2~3 weeks of age after birth. Caspr is a major component of the paranode in myelinated nerves. Disrupted paranodal junctions and aberrant localization of ion channels at the nodal/paranodal regions were found in the central and peripheral nervous system of mutant mice, suggesting a major cause of the mouse neurological phenotype. In aged mice showing progressive neurological deficits, altered axons containing abnormal inclusions and, further, a loss of neuronal somata were found. These findings suggest that the disrupted paranodal junction at the paranode causes the axonal degeneration and neuronal cell death, thus the shm mice is a potential animal model for human neurodegenerative disease.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] A Novel Caspr mutation causes the shambling mouse phenotype by disrupting axoglial Interactions of myelinated nerves.2009
Author(s)
Sun XY, Takagishi Y, Okabe E, Chishima Y, Kanou Y, Murase S, Mizumura K, Inaba M, Komatsu Y, Hayashi Y, Peles E, Oda SI, Murata Y.
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Journal Title
Journal of Neuropathology and Experimental Neurology. 68(11)
Pages: 1207-1218
Related Report
Peer Reviewed
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[Journal Article] A Novel Caspr mutation causes the shambling mouse phenotype by disrupting axoglial Interactions of myelinated nerves.2009
Author(s)
Sun XY, Takagishi Y, Okabe E, Chishima Y, Kanou Y, Murase S, Mizumura K, Inaba M, Komatsu Y, Hayashi Y, Peles E, Oda SI, Murata Y.
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Journal Title
J Neuropathology and Experimental Neurology 68(11)
Pages: 1207-1218
Related Report
Peer Reviewed
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[Presentation] Morphological and functional analysis of the nervous system in shambling mice a Caspr1 mutation.2008
Author(s)
Takagishi Y, Okabe E, Chishima Y, Sun XY, Senoo S, Inaba M, Mizumura K, Komatsu Y, Oda SI, Murata Y.
Organizer
The Society for Neuroscience 38th Annual Meeting
Place of Presentation
Washington DC, USA
Related Report
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[Presentation] Morphological and functional analysis of the nervous system in shambling mice with a Casprl mutation2008
Author(s)
Y. Takagishi, E. Okabe, Y. Chishima, X-Y. Sun, S. Senoo, M. Inaba, K. Mizumura, Y. Komatsu, S. Oda, Y. Murata
Organizer
Society for Neuroscience, 2008
Place of Presentation
ワシントン・コンベンションセンター, ワシントンDC、米国
Related Report
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