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Establishment of a network of model-monkey supply forhuman medical researches

Research Project

Project/Area Number 20500371
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionShiga University of Medical Science

Principal Investigator

TSUCHIYA Hideaki  滋賀医科大学, 動物生命科学研究センター, 技術専門職員 (10378440)

Co-Investigator(Kenkyū-buntansha) ITO Yasushi  滋賀医科大学, 医学部, 准教授 (90324566)
SHIINA Takashi  東海大学, 医学部, 准教授 (00317744)
鳥居 隆三  滋賀医科大学, 動物生命科学研究センター, 教授 (50106647)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsカニクイザル / 人工繁殖 / MHC遺伝子 / モデル動物 / 供給ネットワーク / 室内人工繁殖 / 医療研究用モデルザル / 動物供給ネットワーク / データベース / 生殖細胞
Research Abstract

Cynomolgus monkeys (Macaca fascicularis) live in a broad range of South-East Asia, and nonhuman primates (NHPs) have emerged as important animal models in infectious diseases and transplantation studies. For those studies, it’s necessitating a more extensive characterization of their major histocompatibility complex (MHC) polymorphic regions and MHC homozygous (homo) cynomolgus monkey would have big advantage for immunological research. We have collected a blood samples from many cynomolgus monkey breeding facilities in Japan and South-East Asia, and MHC gene analysis has been initiated. These animals are bred artificially and it is necessary to establish the system to supply. The supply system of these animals was divided into three stages, and it was established. First stage: It cooperates between with each facility and information-material was shared. Second stage: Establishment the indoor artificial breading system with the materials offered from each facility. Third stage: It supplies in order to use the produced MHC identified monkey for research. In this study, we have demonstrated our model monkey supply system followed by indoor artificial breading system could show viable MHC identified monkey and it could work even at infectious diseases and transplantation studies.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (56 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (18 results) Book (1 results) Remarks (7 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Torii R Triplet pregnancy in a cynomolgus monkey (Macaca fascicularis) after double embryo transfer2012

    • Author(s)
      Morichika J, Iwatani C, Tsuchiya H, Nakamura S, Sankai T
    • Journal Title

      Comparative Medicine

      Volume: 62(2) Pages: 69-72

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Triplet pregnancy in a cynomolgus monkey (Macaca fascicularis) after double embryo transfer2012

    • Author(s)
      Morichiya Juri
    • Journal Title

      Comparative Medicine

      Volume: 62/2 Pages: 69-72

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of Hepatitis E Virus in Indoor-Captive Cynomolgus Monkey Colony.2012

    • Author(s)
      Nakamura Shinichirou
    • Journal Title

      J Vet Med Sci.

      Volume: 74 Pages: 279-283

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Triplet pregnancy in a cynomolgus monkey (Macaca fascicularis) after double embryo transfe2012

    • Author(s)
      Morichika J, Iwatani C, Tsuchiya H, Nakamura S, Sankai T, Torii R
    • Journal Title

      Comparative Medicine

      Volume: 62(2) Pages: 69-72

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitrification and transfer of cynomolgus monkey (Macaca fascicularis)embryos fertilized by intracytoplasmic sperm injection2011

    • Author(s)
      Yamasaki J, Iwatani C, Tsuchiya H, Okahara J, Sankai T
    • Journal Title

      Theriogenorogy

      Volume: 76 Pages: 33-38

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitrification and transfer of cynomolgus monkey (Macaca fascicularis) embryos fertilized by intracytoplasmic sperm injection2011

    • Author(s)
      Yamasaki J, Iwatani C, Tsuchiya H, Okahara J, Sankai T, Torii R
    • Journal Title

      Theriogenology

      Volume: 76 Pages: 33-38

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study of suitable FSH dosage for ovarian stimulation for mature oocyte collection using a micro infusion pump in cynomolgus monkey (Macaca fascicularis)2010

    • Author(s)
      Iwatani C, Yamasaki J, Tsuchiya H, Okahara J, Torii R
    • Journal Title

      Exp.Anim. 59(3)

      Pages: 392-392

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Study of suitable FSH dosage for ovarian stimulation for mature oocyte collection using a micro infusion pump in cynomolgus monkey (Macaca fascicularis)2010

    • Author(s)
      Iwatani C., et.al.
    • Journal Title

      Experimental Animals

      Volume: 59(3) Pages: 392-392

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of chromosome segregation using live-cell imaging in cynomolgus monkey (Macaca fascicularis)2010

    • Author(s)
      Yamasaki J., et.al.
    • Journal Title

      Immunogenetics.

      Volume: 59(3) Pages: 394-394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque2009

    • Author(s)
      Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T
    • Journal Title

      Immunogenetics

      Volume: 61(9) Pages: 635-648

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MHC class I A loci polymorphism and diversity in three Southeast Asian populations of cynomolgus macaque.2009

    • Author(s)
      Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T.
    • Journal Title

      Immunogenetics. 61(9)

      Pages: 635-648

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Succesful delivery after vitrification of cynomolgus monkey embryos using the CryotomTM2009

    • Author(s)
      Yamasaki J, Okahara-Narita J, Iwatani C, Tsuchiya H, Torii R
    • Journal Title

      Exp Anim 58(3)

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Succesfuldelivery after vitrification of cynomolgus monkey embryos using theCryotomTM2009

    • Author(s)
      Yamasaki J., et. al.
    • Journal Title

      Experimental Animals 58(3)

      Pages: 101-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MHC class I A loci polymorphismand diversity in three Southeast Asian populations of cynomolgus macaque.2009

    • Author(s)
      Kita Y.F., et. al.
    • Journal Title

      Immunogenetics. 61(9)

      Pages: 635-648

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A vaccine prepared from a non-pathogenic H5N1 avian influenza virus stain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus monkey2008

    • Author(s)
      Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H
    • Journal Title

      Vaccine

      Volume: 26 Pages: 562-572

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A vaccine prepared from a non-pathogenic H5N1 avian influenza virus stain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus monkey2008

    • Author(s)
      Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H.
    • Journal Title

      Vaccine 26

      Pages: 562-572

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Clonal offspring derived from separated blastomeres in cynomolgus monkey (Macaca fascicularis)2008

    • Author(s)
      Iwatani C, Okahara-Narita J, Yamasaki J, Tsuchiya H, Torii R
    • Journal Title

      Reproduction, Fertility and Development 20

      Pages: 100-100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of hoechst staining for nuclear transfer on parthenogenetic embryos in cynomolgus monkey (Macaca fascicularis)2008

    • Author(s)
      Tsuchiya H, Iwatani C, Okahara-Narita J, Yamasaki J, Torii R
    • Journal Title

      Reproduction, Fertility and Development 20

      Pages: 111-111

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of epidermal growth factor on in vitro maturation of cynomolgus monkey (Macaca fascicularis) oocytes2008

    • Author(s)
      Yamasaki J, Okahara-Narita J, Iwatani C, Tsuchiya H, Torii R
    • Journal Title

      Reproduction, Fertility and Development 20

      Pages: 208-208

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cynomolgus monkey embryonic stem cell line derived from a single blastomere2008

    • Author(s)
      Okahara-Narita J, Yamasaki J, Iwatani C, Tsuchiya H. Torii R
    • Journal Title

      Reproduction, Fertility and Development 20

      Pages: 224-225

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective condition for maturation of cynomolgus monkey (Macaca fascicularis)oocytes in vitro2008

    • Author(s)
      Yaraasaki J, Okahara-Narita J, Iwatani C, Tsuchiya H, Toril R
    • Journal Title

      Exp. Anim 57

      Pages: 272-272

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Success in deliveries of clonal offspring derived from separated blastomeres in cynomolgus monkey (Macaca fascicularis)2008

    • Author(s)
      Iwatani C, Okahara-Narita J, Yamasaki J, Tsuchiya H, Torii R
    • Journal Title

      Exp. Anim 57

      Pages: 273-273

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ES cell line derived from a single blastomere in cynomolgus monkey2008

    • Author(s)
      Okahara-Narita J, Yamasaki J, Iwatani C, Tsuchiya H, Torii R
    • Journal Title

      Exp. Anim 57

      Pages: 232-273

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cultivated corneal endotherial transplantation in a primate : Possible future clinical application in corneal endotherial regenerative medicine2008

    • Author(s)
      Koizumi N. Sakamoto Y, Okumura N, Tsuchiya H, Torii R, Cooper LJ, Ban Y, Tanioka H, Kinoshita S
    • Journal Title

      Cornea 27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BMP4 induces primate endoderm but not trophectoderm in monkey embryonic stem cell2008

    • Author(s)
      Kobayashi M, Takasa T, Takahashi K, Noda Y, Torii R
    • Journal Title

      Cloning and stem Cells 10

      Pages: 495-502

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト医療研究用モデルザル供給ネットワークの構築2013

    • Author(s)
      土屋英明、中川孝博、河本育士、岩谷千鶴、中村紳一朗、山中久、椎名隆、小笠原一誠
    • Organizer
      日本実験動物技術者協会 第47回総会
    • Place of Presentation
      岡山
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト医療研究用モデルザル供給ネットワークの構築2013

    • Author(s)
      土屋英明
    • Organizer
      平成25年度 実験動物技術者協会総会
    • Place of Presentation
      岡山県倉敷市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 実験動物個体情報管理システムの構築2013

    • Author(s)
      岩谷千鶴
    • Organizer
      平成25年度 実験動物技術者協会総会
    • Place of Presentation
      岡山県倉敷市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ovarian stimulation in cynomolgus monkeys by a controlled release of follicular stimulating hormone utilizing a microinfusion pump2012

    • Author(s)
      Iwatani C, Yamasaki J, Kusanagi A, Tsuchiya H, Torii R
    • Organizer
      The 38th Annual Conference of the International Embryo Transfer Society
    • Place of Presentation
      USA, Arizona
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成熟卵子採取のためのインフュージョンポンプによるカニクイザル卵巣刺激法2010

    • Author(s)
      岩谷 千鶴、山崎 樹里、土屋英明、岡原 純子、鳥居 隆三
    • Organizer
      日本生殖再生医学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] カニクイザル顕微授精胚へのライブセルイメージング法の適用2010

    • Author(s)
      山崎樹里、山縣一夫、岩谷千鶴、土屋英明、岡原純子、若山照彦、鳥居隆三
    • Organizer
      日本生殖再生医学会 第5回学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] カニクイザルにおける適切な性腺刺激ホルモン微量連続投与法の検討2010

    • Author(s)
      岩谷 千鶴、山崎 樹里、土屋英明、岡原 純子、鳥居 隆三
    • Organizer
      第57回 日本実験動物学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] カニクイザル顕微授精胚のライブセルイメージングによる染色体分裂像の観察2010

    • Author(s)
      山崎樹里、山縣一夫、岩谷千鶴、土屋英明、岡原純子、若山照彦、鳥居隆三
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] カニクイザル受精卵における着床前遺伝子診断用サンプル採取の検討2010

    • Author(s)
      小山周三、藤波菜穂子、土屋英明、福田浩司、松下聡紀、渡邊翔、小原栄、宇野康宏、鳥居隆三、細井美彦
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 育成カニクイザル飼育システムの開発2010

    • Author(s)
      土屋英明
    • Organizer
      第44回日本実験動物技術者協会総会
    • Place of Presentation
      旭川
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 育成カニクイザル飼育システムの開発2010

    • Author(s)
      土屋英明, 他
    • Organizer
      第44回日本実験動物技術者協会総会
    • Place of Presentation
      北海道旭川市
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロインフュージョンポンプを用いたカニクイザル卵巣刺激法の検討2009

    • Author(s)
      岩谷千鶴, 他
    • Organizer
      第56回日本実験動物学会総会
    • Place of Presentation
      埼玉県大宮市
    • Related Report
      2009 Annual Research Report
  • [Presentation] カニクイザル連続微量投与による卵巣刺激法の検討2008

    • Author(s)
      岩谷千鶴, 山崎樹里, 岡原純子, 土屋英明, 鳥居隆三
    • Organizer
      関西実験動物研究会第100回記念大会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] クライオトップを用いたカニクイザル顕微授精胚の凍結保存および凍結胚由来産子の獲得2008

    • Author(s)
      山崎樹里, 岡原純子, 岩谷千鶴, 土屋英明, 鳥居隆三
    • Organizer
      関西実験動物研究会第100回記念大会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] カニクイザル分割クローン個体の作出2008

    • Author(s)
      岩谷千鶴, 岡原(成田)純子, 山, 樹里, 土屋英明, 鳥居隆三
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Related Report
      2008 Annual Research Report
  • [Presentation] カニクイザル未成熟卵子の体外成熟培養における支持細胞およびEGF添加濃度の検討2008

    • Author(s)
      山, 樹里, 岡原純子, 岩谷千鵬, 土屋英明, 櫻川宣男, 鳥居隆三
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Related Report
      2008 Annual Research Report
  • [Presentation] カニクイザルにおける単一割球からのES細胞の樹立2008

    • Author(s)
      岡原(成田)純子, 山, 樹里, 岩谷千鶴, 土屋英明, 鳥居隆三
    • Organizer
      第55回日本実験動物学会総会
    • Place of Presentation
      仙台
    • Related Report
      2008 Annual Research Report
  • [Presentation] Abnormal distribution of cortical granules in monkey one-day old MII oocytes which were immature at oocyte retrival after controlled ovarian hyperstimulation2008

    • Author(s)
      Yaraanaka M, Hashimoto S, Okahara J, Yaraasaki J, ToriiR, Morimoto R
    • Organizer
      American Society for Reproductive Medicine 64th Annual Meeting
    • Place of Presentation
      San Francisco, California, USA
    • Related Report
      2008 Annual Research Report
  • [Book] サル胚性幹細胞、「卵子学」2011

    • Author(s)
      鳥居隆三
    • Total Pages
      1180
    • Publisher
      京都大学学術出版会
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqanimal/

    • Related Report
      2012 Final Research Report
  • [Remarks] 滋賀医科大学 動物生命科学研究センター ホームページ

    • URL

      http://www.shiga-med.ac.jp/~hqanimal/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.shiga-med.ac.jp/~hqanimal/

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqanimal/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] カニクイザル MHC 全遺伝子ホモ接合体を作製するためのキット及び方法2010

    • Inventor(s)
      小笠原一誠、鳥居隆三、椎名隆
    • Industrial Property Rights Holder
      滋賀医科大学、東海大学
    • Industrial Property Number
      2010-105956
    • Filing Date
      2010-04-30
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] カニクイザルMHC 全遺伝子ホモ接合体を作製するためのキット及び方法2010

    • Inventor(s)
      小笠原一誠、鳥居隆三、椎名隆
    • Industrial Property Rights Holder
      滋賀医科大学、東海大学
    • Industrial Property Number
      2010-105956
    • Filing Date
      2010-04-30
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] カニクイザルMHC全遺伝子ホモ接合体を作製するためのキット及び方法2010

    • Inventor(s)
      小笠原一誠, 鳥居隆三, 椎名隆
    • Industrial Property Rights Holder
      滋賀医科大学 東海大学
    • Industrial Property Number
      2010-105956
    • Filing Date
      2010-04-30
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ガス吸引補助具2009

    • Inventor(s)
      土屋英明、鳥居隆三
    • Industrial Property Rights Holder
      滋賀医科大学、藤原三郎
    • Acquisition Date
      2009-08-05
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 汚物廃棄処理装置2009

    • Inventor(s)
      土屋英明、鳥居隆三
    • Industrial Property Rights Holder
      滋賀医科大学、藤原三郎
    • Acquisition Date
      2009-08-05
    • Related Report
      2010 Self-evaluation Report

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Published: 2008-04-01   Modified: 2019-07-29  

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