Macaques as animal model for gamma-herpesvirus associated lymphomas

• Project/Area Number: 20500372
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Kyoto University
• Principal Investigator: SUZUKI Juri 京都大学, 霊長類研究所, 准教授 (10175408)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Takafumi 東京大学, 理学系研究科, 准教授 (20184533)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ガンマヘルペスウイルス / 疾患モデル / マカク / リンパ腫 / ニホンザル / タイワンザル

Research Abstract

We surveyed for the prevalence of gamma-herpes virus(γHV) or sEBV and 2) found out possible malignant cases caused by theγHVs infection retrospectively in Japanese macaques(Macaca fuscata) and Taiwanese macaques(M. cyclopis). We found that the incidence of the lymphoma was very low compared to the high prevalence of sEBV in those macaque species. Two cases suffering from NK/T-cell lymphoma associated with sEBV in Japanese macaques and Taiwanese macaques were detected. Those results suggest that both two species are suitable for an animal model for human lymphoma associated withγHV.

Research Products

• [Journal Article] SRV-4の関与が疑われるニホンザルの血小板減少症 (2012)
  • Author(s): 鈴木樹理、明里宏文、岡本宗裕、吉田友教、岡林佐知
  • Journal Title: オベリスク Volume: 17 Pages: 5-10
• [Journal Article] Short communication epidemiological evidence that simian T-lymphotropic virus type 1 in Macaca fuscata has an alternative transmission route to maternal infection (2011)
  • Author(s): Eguchi K, Ohsawa K, Fuse Kiyono M, Suzuki J, Kurokawa K, Yamamoto T
  • Journal Title: AIDS Res Hum Retroviruses Volume: 27(2) Pages: 113-114
  • Peer Reviewed
• [Journal Article] Differential prefrontal white matter development in chimpanzees and humans (2011)
  • Author(s): Sakai T, Mikami A, Tomonaga M, Matsui M, Suzuki J, Hamada Y, Tanaka M, Miyabe-Nishiwaki T, Makishita H, Nakatsukasa M, Matsuzawa T
  • Journal Title: Current Biology Volume: 21 Pages: 1397-1402
  • Peer Reviewed
• [Journal Article] Molecular evolution of immunoglobulin superfamily genes in primates (2011)
  • Author(s): Ohtani H, Nakajima T, Akari H, Ishida T, Kimura A
  • Journal Title: Immunogenetics Volume: 63 Pages: 417-428
  • Peer Reviewed
• [Journal Article] Short communication : epidemiological evidence that simian T-lymphotropic virus type 1 in Macaca fuscata has an alternative transmission route to maternal infection (2011)
  • Author(s): Eguchi K, Ohsawa K, Fuse KM, Suzuki J, Kurokawa K, Yamamoto T
  • Journal Title: AIDS Res Hum Retroviruses Volume: 27 Pages: 113-114
  • Peer Reviewed
• [Journal Article] Tetraparesis resembling acute transverse myelitis in a captive chimpanzee(Pan troglodytes): long-term care and recovery (2010)
  • Author(s): Miyabe-Nishiwaki T, Kaneko A, Nishiwaki K, Watanabe A, Watanabe S, Maeda N, Kumazaki K, Morimoto M, Hirokawa R, Suzuki J, Ito Y, Hayashi M, Tanaka M, Tomonaga M, Matsuzawa T
  • Journal Title: Journal of Medical Primatology Volume: 39(5) Pages: 336-346
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus strain defined by LMP1 sequence characterizes Thai ethnic groups (2010)
  • Author(s): Saechan V, Settheetham-Ishida W, Kimura R, Tiwawech D, Mitarnun W, Ishida T
  • Journal Title: Journal of General Virology Volume: 91 Pages: 2054-2061
  • Peer Reviewed
• [Journal Article] Reactivation of lymphocryptovirus(EBVcmp) and the dominance in chimpanzees (2010)
  • Author(s): Yamamoto R, Teramoto M, Hayasaka I, Ikeda K, Hasegawa T, Ishida T
  • Journal Title: Journal of General Virology Volume: 91 Pages: 2049-2053
  • Peer Reviewed
• [Journal Article] Primate species in Darwin's major books on evolution (2009)
  • Author(s): Sri Kantha S, Suzuki J
  • Journal Title: Current Science Volume: 97(5) Pages: 715-718
  • Peer Reviewed
• [Journal Article] Owl monkey vocalizations at the Primate Research Institute (2009)
  • Author(s): Sri Kantha S, Koda H, Suzuki J
  • Journal Title: Neotropical Primates Volume: 16(1) Pages: 43-46
  • Peer Reviewed
• [Journal Article] Behavioral sleep in captive owl monkey(Aotus azarae) and squirrel monkey (2009)
  • Author(s): Sri Kantha S, Suzuki J, Hirai Y, Hirai H
  • Journal Title: Acta Neurobiologiae Experimentalis Volume: 69 Pages: 537-544
  • Peer Reviewed
• [Journal Article] Behavioral sleep in captive owl monkey (Aotus azarae) and squirrel monkey (Saimiri boliviensis). (2009)
  • Author(s): Sri Kantha S, et al.
  • Journal Title: Acta Neurobiologiae Experimentalis 69 Pages: 537-544
  • Peer Reviewed
• [Journal Article] Owl monkey vocalizations at the Primate Research Institute, Inuyama. (2009)
  • Author(s): Sri Kantha S, et al.
  • Journal Title: Neotropical Primates 16 Pages: 43-46
  • Peer Reviewed
• [Journal Article] Primate species in Darwin's major books on evolution. (2009)
  • Author(s): Sri Kantha S, et al.
  • Journal Title: Current Science 97 Pages: 715-718
  • Peer Reviewed
• [Journal Article] Development of the superlaryngeal vocal tract in Japanese macaques (2008)
  • Author(s): Nishimura T, Oishi T, Suzuki J, Matsuda K, Takahashi T
  • Journal Title: Implications for the evolution of the descent of the larynx, American Journal of Physical Anthropology Volume: 135 Pages: 182-194
  • Peer Reviewed
• [Journal Article] Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais (2008)
  • Author(s): Tiwawech D, Srivatanakul P, Karaluk A, Ishida T
  • Journal Title: Journal of Clinical Virology Volume: 42 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Detection of IgA antibody against Epstein-Barr virus nuclear antigen 1 in nasopharyngeal carcinoma patients by ELISA (2008)
  • Author(s): Tiwawech D, Chindavijak S, Karalak A, Ishida T
  • Journal Title: Thai Cancer Journal Volume: 28 Pages: 83-92
  • Peer Reviewed
• [Journal Article] Natural selection in the TRL-related genes in thecourse of primate evolution (2008)
  • Author(s): Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura, A
  • Journal Title: Immunogenetics Volume: 60 Pages: 727-735
  • Peer Reviewed
• [Journal Article] Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais. (2008)
  • Author(s): Tiwawech, et al.
  • Journal Title: Journal of Clinical Virology 42 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Natural selection in the TRL-related genes in the course of primate evolution. (2008)
  • Author(s): Nakajima, et al.
  • Journal Title: Immunogenetics 60 Pages: 727-735
  • Peer Reviewed
• [Journal Article] Sleep parameters in captive female owl monkey (Aotus) hybrids. (2007)
  • Author(s): Sri Kantha, et al.
  • Journal Title: Neotropical Primates 14 Pages: 141-144
  • Peer Reviewed
• [Presentation] SRV-4の関与が疑われる血小板減少症 (2011)
  • Author(s): 鈴木樹理、明里宏文、岡本宗裕、吉田友教、岡林佐知
  • Organizer: 第20回サル疾病ワークショップ
  • Place of Presentation: 神奈川
  • Year and Date: 2011-07-02
• [Presentation] SRV-4の関与が疑われる血小板減少症 (2011)
  • Author(s): 鈴木樹理、明里宏文、岡本宗裕、吉田友教、岡林佐知
  • Organizer: 第20回サル疾病ワークショップ
  • Place of Presentation: 麻布大学(神奈川県)
  • Year and Date: 2011-07-02
• [Presentation] 京大霊長研に見られたニホンザル血小板減少症(1):概要報告 (2011)
  • Author(s): 明里宏文、鈴木樹理、岡本宗裕、宮部貴子、渡邉朗野、兼子明久、熊崎清則、阿部政光、鎌中慶朗、前田典彦、森本真弓、渡邊祥平、須田直子、平井啓久、松沢哲郎
  • Organizer: 第58回日本実験動物学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-05-26
• [Presentation] 京大霊長研に見られたニホンザル血小板減少症(3):病理学的解析 (2011)
  • Author(s): 岡林佐知、渡邊朗野、兼子明久、宮部貴子、中山裕之、内田和幸、大野智恵子、小野文子、藤本浩二、倉田毅、Yee, JoAnn、鈴木樹理
  • Organizer: 第58回日本実験動物学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-05-26
• [Presentation] 京大霊長研に見られたニホンザル血小板減少症(4):疫学調査 (2011)
  • Author(s): 吉田友教、岡本宗裕、明里宏文、今井啓雄、松井淳、早川敏之、生駒智子、伯川美穂、齊藤波子、渡邉朗野、兼子明久、宮部貴子、鈴木樹理、平井啓久
  • Organizer: 第58回日本実験動物学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-05-26
• [Presentation] Health management of macaque outdoor colonies with focus on hepatitis E infection (2010)
  • Author(s): Suzuki J, Yamamoto H, Matsuda A, Ishida T, LiT-C, Takeda N
  • Organizer: International Primatological Society 23rd Congress Kyoto 2010
  • Place of Presentation: Kyoto
• [Presentation] Natural hepatitis E virus infection in macaque colonies (2009)
  • Author(s): Suzuki J, Yamamoto H, Matsuda A, Ishida T, LiT-C, Takeda N
  • Organizer: The 3rd International Workshop of Asian Society of Zoo and Wildlife Medicine & 1st Meeting of Korean Society of Zoo and Wildlife Medicine
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-08-18
• [Presentation] Natural hepatitis E virus infection in macaque colonies. (2009)
  • Author(s): Suzuki J, et al.
  • Organizer: The 3rd International Workshop of Asian Society of Zoo and Wildlife Medicine
  • Place of Presentation: Seoul, Korea
• [Presentation] Malignant lymphoma(plasma cell neoplasm) in a long-tailed macaque(Macaca fascicularis) (2008)
  • Author(s): Suzuki J, Kato A, Kaneko A, Takao S, Ishida T, Isowa K
  • Organizer: Joint meeting of the 3rd international meeting on Asian Zoo/Wildlife Medicine and Conservation
  • Place of Presentation: Bogor, Indonesia
  • Year and Date: 2008-08-20
• [Presentation] Malignant lymphoma (plasma cell neoplasm) in a long-tailed macaque (Macaca fascicularis). (2008)
  • Author(s): Suzuki, et al.
  • Organizer: Joint meeting of the 3rd international meeting on Asian Zoo/Wildlife Medicine and Conservation
  • Place of Presentation: Bogor, Indonesia
  • Year and Date: 2008-08-20
• [Book] サル類の疾病カラーアトラス (2011)
  • Author(s): 吉川泰弘、宇根有美、後藤俊二、小野文子、鈴木樹理, 他
  • Publisher: 予防衛生協会
• [Book] サル類の疾病カラーアトラス (2011)
  • Author(s): 吉川泰弘、宇根有美、後藤俊二、小野文子、鈴木樹理, 他
  • Total Pages: 204
  • Publisher: 社団法人予防衛生協会
• [Book] 新しい霊長類学「人を深く知るための100問100答」 (2009)
  • Author(s): 鈴木樹理
  • Publisher: 講談社
• [Remarks] 総説(1)鈴木樹理、霊長類のストレスを測る、生き物たちのつづれ織り、査読無、3、2010、132-136